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001-es BibID:	BIBFORM116533
035-os BibID:	(scopus)85168619897 (wos)001063398000003
Első szerző:	Safanda, Adam
Cím:	Immunohistochemical expression of PRAME in 485 cases of epithelial tubo-ovarian tumors / Safanda Adam, Kendall Bártu Michaela, Michálková Romana, Struzinská Ivana, Drozenová Jana, Fabián Pavel, Hausnerová Jitka, Laco Jan, Matej Radoslav, Skapa Petr, Svajdler Marián, Spurková Zuzana, Méhes Gábor, Dundr Pavel, Nemejcová Kristyna
Dátum:	2023
ISSN:	0945-6317
Megjegyzések:	Preferentially expressed antigen of melanoma (PRAME) is a cancer/testis antigen selectively expressed in somatic tissues and various solid malignant tumors and is associated with poor prognostic outcome. Our research aimed to comprehensively compare its expression in a large cohort of tubo-ovarian epithelial tumors and examine its correlation with our clinico-pathologic data, as well as to assess its potential use in diagnostics and therapy. We examined 485 cases of epithelial tubo-ovarian tumors including 107 clear cell carcinomas (CCC), 52 endometroid carcinomas (EC), 103 high grade serous carcinomas (HGSC), 119 low grade serous carcinomas (LGSC)/micropapillary variant of serous borderline tumors (mSBT), and 104 cases of mucinous carcinomas (MC)/mucinous borderline tumors (MBT). The immunohistochemical analysis was performed using TMAs. The highest levels of expression were seen in EC (60%), HGSC (62%), and CCC (56%), while expression in LGSC/mSBT (4%) and MC/MBT (2%) was rare. The clinico-pathologic correlations and survival analysis showed no prognostic significance. The results of our study showed that PRAME is neither prognostic nor a suitable ancillary marker in the differential diagnosis of tubo-ovarian epithelial tumors. Nevertheless, knowledge about the PRAME expression may be important concerning its potential predictive significance, because targeting PRAME as a potential therapeutic option is currently under investigation.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Cancer Immunohistochemistry Ovarian tumors PRAME
Megjelenés:	Virchows Archiv. - 483 : 4 (2023), p. 509-516. -
További szerzők:	Kendall Bártů, Michaela Michálková, Romana Struzinská, Ivana Drozenová, Jana Fabian, Pavel Hausnerová, Jitka Laco, Jan Matej, Radoslav Škapa, Petr Svajdler, Marián Špůrková, Zuzana Méhes Gábor (1966-) (patológus) Dundr, Pavel Nĕmejcová, Kristýna
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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