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001-es BibID:	BIBFORM120119
035-os BibID:	(Scopus)85164313272 (WoS)000841806700001
Első szerző:	Yoshida, Akira
Cím:	Impaired physical function in patients with idiopathic inflammatory myopathies : results from the multicentre COVAD patient-reported e-survey / Akira Yoshida, Minchul Kim, Masataka Kuwana, Naveen Ravichandran, Ashima Makol, Parikshit Sen, James B. Lilleker, Vishwesh Agarwal, Sinan Kardes, Jessica Day, Marcin Milchert, Mrudula Joshi, Tamer Gheita, Babur Salim, Tsvetelina Velikova, Abraham Edgar Gracia-Ramos, Ioannis Parodis, Albert Selva O`Callaghan, Elena Nikiphorou, Tulika Chatterjee, Ai Lyn Tan, Arvind Nune, Lorenzo Cavagna, Miguel A. Saavedra, Samuel Katsuyuki Shinjo, Nelly Ziade, Johannes Knitza, Oliver Distler, Hector Chinoy, Vikas Agarwal, Rohit Aggarwal, Latika Gupta, COVAD Study Group
Dátum:	2023
ISSN:	1462-0324 1462-0332
Megjegyzések:	Objectives: The assessment of physical function is fundamental in the management of patients with idiopathic inflammatory myopathies (IIMs). We aimed to investigate the physical function of patients with IIMs compared with those with non-IIM autoimmune rheumatic diseases (AIRDs) utilizing Patient-Reported Outcome Measurement Information System (PROMIS) Physical Function (PF) data obtained in the COVAD study, an international self-reported e-survey assessing the safety of COVID-19 vaccines in AIRDs. Methods: Demographics, AIRD diagnosis, disease activity, and PROMIS PF short form-10a data were extracted from the COVAD database. PROMIS PF-10a scores were compared between disease categories and stratified by disease activity. Factors affecting PROMIS PF-10a scores other than disease activity were identified by multivariable regression analysis in patients with inactive disease. Results: A total of 1057 IIM patients, 3635 non-IIM AIRD patients and 3981 healthy controls (HCs) responded to the COVAD e-survey from April to August 2021. Using a binomial regression model, the predicted mean of PROMIS PF-10a scores was significantly lower in IIM patients compared with non-IIM AIRD patients or HCs [36.3 (95% CI 35.5, 37.1) vs 41.3 (95% CI 40.2, 42.5) vs 46.2 (95% CI 45.8, 46.6), P < 0.001], irrespective of disease activity. The independent factors for lower PROMIS PF-10a scores in patients with inactive disease were older age, female, longer disease duration, and a diagnosis of inclusion body myositis or polymyositis. Conclusion: Physical function is significantly impaired in IIMs compared with non-IIM AIRDs or HCs, even in patients with inactive disease. Our study highlights a critical need for better strategies to minimize functional disability in patients with IIMs.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk COVAD Myositis PROMIS e-survey patient-reported outcome measures physical function
Megjelenés:	Rheumatology. - 62 : 3 (2023), p. 1204-1215. -
További szerzők:	Kim, Minchul Kuwana, Masataka Ravichandran, Naveen Makol, Ashima Sen, Parikshit Lilleker, James B. Agarwal, Vishwesh Kardes, Sinan Day, Jessica Milchert, Marcin Joshi, Mrudula Gheita, Tamer A. Salim, Babur Velikova, Tsvetelina Edgar Gracia-Ramos, Abraham Parodis, Ioannis Selva-O'Callaghan, Albert Nikiphorou, Elena (reumatológus) Chatterjee, Tulika Tan, Ai Lyn Nune, Arvind Cavagna, Lorenzo Saavedra, Miguel A. Shinjo, Samuel Katsuyuki Ziade, Nelly Knitza, Johannes Distler, Oliver Chinoy, Hector Agarwal, Vikas Aggarwal, Rohit Gupta, Latika Nagy-Vincze Melinda (1985-) (orvos) COVAD Study Group
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