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001-es BibID:	BIBFORM122702
035-os BibID:	(WoS)001231256600001 (Scopus)85194191374
Első szerző:	Kastal Zsuzsa
Cím:	Copper(II), Nickel(II) and Zinc(II) Complexes of Peptide Fragments of Tau Protein / Zsuzsa Kastal, Adrienn Balabán, Szilvia Vida, Csilla Kállay , Lajos Nagy, Katalin Várnagy, Imre Sóvágó
Dátum:	2024
ISSN:	1420-3049
Megjegyzések:	Copper(II), nickel(II) and zinc(II) complexes of various peptide fragments of tau protein were studied by potentiometric and spectroscopic techniques. All peptides contained one histidyl residue and represented the sequences of tau(91-97) (Ac-AQPHTEI-NH2 ), tau(385-390) (Ac-KTDHGA-NH2 ) and tau(404-409) (Ac-SPRHLS-NH2 ). Imidazole-N donors of histidine were the primary metal binding sites for all peptides and all metal ions, but in the case of copper(II) and nickel(II), the deprotonated amide groups were also involved in metal binding by increasing pH. The most stable complexes were formed with copper(II) ions, but the presence of prolyl residues resulted in significant changes in the thermodynamic stability and speciation of the systems. It was also demonstrated that nickel(II) and especially zinc(II) complexes have relatively low thermodynamic stability with these peptides. The copper(II)-catalyzed oxidation of the peptides was also studied. In the presence of H2O2 , the fragmentation of peptides was detected in all cases. In the simultaneous presence of H2O2 and ascorbic acid, the fragmentation of the peptide is less preferred, and the formation of 2-oxo-histidine also occurs.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk tau protein histidine-containing fragments copper(II) complex zinc(II) complex nickel(II) complex copper(II) catalyzed oxidation potentiometry UV-Vis spectroscopy CD spectroscopy
Megjelenés:	Molecules. - 29 : 10 (2024), p. 1-18. -
További szerzők:	Balabán Adrienn Vida Szilvia Kállay Csilla (1978-) (vegyész) Nagy Lajos (1979-) (vegyész) Várnagy Katalin (1961-) (vegyész) Sóvágó Imre (1946-) (vegyész)
Pályázati támogatás:	University of Debrecen Program for Scientific Publication Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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