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001-es BibID:	BIBFORM125756
035-os BibID:	(Scopus)85203046278 (WOS)001312162800001
Első szerző:	Mourkas, Evangelos
Cím:	Proximity to humans is associated with antimicrobial-resistant enteric pathogens in wild bird microbiomes / Mourkas, Evangelos; Valdebenito, José O.; Marsh, Hannah; Hitchings, Matthew D.; Cooper, Kerry K.; Parker, Craig T.; Székely, Tamás; Johansson, Håkan; Ellström, Patrik; Pascoe, Ben; Waldenström, Jonas; Sheppard, Samuel K.
Dátum:	2024
ISSN:	0960-9822
Megjegyzések:	Humans are radically altering global ecology, and one of the most apparent human-induced effects is urbanization, where high-density human habitats disrupt long-established ecotones. Changes to these transitional areas between organisms, especially enhanced contact among humans and wild animals, provide new opportunities for the spread of zoonotic pathogens. This poses a serious threat to global public health, but little is known about how habitat disruption impacts cross-species pathogen spread. Here, we investigated variation in the zoonotic enteric pathogen Campylobacter jejuni. The ubiquity of C. jejuni in wild bird gut microbiomes makes it an ideal organism for understanding how host behavior and ecology influence pathogen transition and spread. We analyzed 700 C. jejuni isolate genomes from 30 bird species in eight countries using a scalable generalized linear model approach. Comparing multiple behavioral and ecological traits showed that proximity to human habitation promotes lineage diversity and is associated with antimicrobial-resistant (AMR) strains in natural populations. Specifically, wild birds from urban areas harbored up to three times more C. jejuni genotypes and AMR genes. This study provides novel methodology and much-needed quantitative evidence linking urbanization to gene pool spread and zoonoses. ? 2024 Elsevier Inc.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk antimicrobial resistance Campylobacter ecology genomics transmission wild birds
Megjelenés:	Current Biology. - 34 : 17 (2024), p. 3955-3965. -
További szerzők:	Valdebenito, José Osvaldo Marsh, Hannah Hitchings, Matthew D. Cooper, Kerry K. Parker, Craig T. Székely Tamás (1959-) (biológus) Johansson, Håkan Ellström, Patrik Pascoe, Ben Waldenström, Jonas Sheppard, Samuel K.
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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