Találati lista | Tudóstér

001-es BibID:	BIBFORM100533
035-os BibID:	(WOS)000921625300001 (Scopus)85125182760
Első szerző:	Furka Andrea (sebész)
Cím:	Treatment Algorithm for Cancerous Wounds : a Systematic Review / Furka Andrea, Simkó Csaba, Kostyál László, Szabó Imre, Valikovics Anikó, Fekete Gábor, Tornyi Ilona, Oross Endre, Révész János
Dátum:	2022
ISSN:	2072-6694
Megjegyzések:	Background: In advanced cancer stage the incidence of cancerous wounds is about 5%, and the estimated life expectancy is not more than 6 to 12 months. Without interdisciplinary and individualized treatment strategy, symptoms progress, and adversely influence quality of life. Methods: Authors collected different treatment algorithms for cancerous wound published by wide scale of medical expertise, and summarized surgical, oncological, radiation oncological, nursing and palliative care aspects based on radiological information. Results: Interdisciplinary approach with continuous consultation between various specialists can solve or ease the hopeless cases. Conclusions: This distressing condition needs a comprehensive treatment solution to alleviate severe symptoms. Non-healing fungating wounds without effective therapy are severe socio-economic burden for all participants, including patients, caregivers, and health services. In this paper authors collected recommendations for further guideline that is essential in the near future.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk cancerous wound treatment algorithm multimodal aspects surgery oncology radiotherapy palliative care
Megjelenés:	Cancers. - 14 : 5 (2022), p. 1-12. -
További szerzők:	Simkó Csaba Kostyál László (1974-) (radiológus) Szabó Imre (1952-) (orvos) Valikovics Anikó Fekete Gábor Tornyi Ilona (1982-) (molekuláris biológus) Oross Endre Révész János
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM127700
035-os BibID:	(WoS)001429655400001
Első szerző:	Márton Éva (biológus)
Cím:	Non-Coding RNAs in Cancer : structure, Function, and Clinical Application / Éva Márton, Alexandra Varga, Dóra Domoszlai, Gergely Buglyó, Anita Balázs, András Penyige, István Balogh, Bálint Nagy, Melinda Szilágyi
Dátum:	2025
ISSN:	2072-6694
Megjegyzések:	We are on the brink of a paradigm shift in both theoretical and clinical oncology. Genomic and transcriptomic profiling, alongside personalized approaches that account for individual patient variability, are increasingly shaping discourse. Discussions on the future of personalized cancer medicine are mainly dominated by the potential of non-coding RNAs (ncRNAs), which play a prominent role in cancer progression and metastasis formation by regulating the expression of oncogenic or tumor suppressor proteins at transcriptional and post-transcriptional levels; furthermore, their cell-free counterparts might be involved in intercellular communication. Non-coding RNAs are considered to be promising biomarker candidates for early diagnosis of cancer as well as potential therapeutic agents. This review aims to provide clarity amidst the vast body of literature by focusing on diverse species of ncRNAs, exploring the structure, origin, function, and potential clinical applications of miRNAs, siRNAs, lncRNAs, circRNAs, snRNAs, snoRNAs, eRNAs, paRNAs, YRNAs, vtRNAs, and piRNAs. We discuss molecular methods used for their detection or functional studies both in vitro and in vivo. We also address the challenges that must be overcome to enter a new era of cancer diagnosis and therapy that will reshape the future of oncology.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk cancer cancer diagnostics cancer therapy RNA RNA detection miRNA lncRNA circRNA snRNA snoRNA
Megjelenés:	Cancers. - 17 : 4 (2025), p. 1-41. -
További szerzők:	Beke-Varga Alexandra Edit (1994-) (molekuláris biológus) Domoszlai Dóra (1999-) (molekuláris biológus) Buglyó Gergely (1980-) (genetikus) Balázs Anita (1984-) (molekuláris biológus) Penyige András (1954-) (molekuláris genetikus) Balogh István (1972-) (molekuláris biológus, genetikus) Nagy Bálint (1956-) (molekuláris genetikus) Szilágyi Melinda (1984-) (biológus)
Pályázati támogatás:	OTKA-138021 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM102993
035-os BibID:	(WOS)000839249500001 (Scopus)85136586949
Első szerző:	Styk, Jakub
Cím:	Extracellular Nucleic Acids in the Diagnosis and Progression of Colorectal Cancer / Styk Jakub, Buglyó Gergely, Pös Ondrej, Csók Ádám, Soltész Beáta, Lukasz Peter, Repiská Vanda, Nagy Bálint, Szemes Tomás
Dátum:	2022
ISSN:	2072-6694
Megjegyzések:	Colorectal cancer (CRC) is the 3rd most common malignant neoplasm worldwide, with more than two million new cases diagnosed yearly. Despite increasing efforts in screening, many cases are still diagnosed at a late stage, when mortality is high. This paper briefly reviews known genetic causes of CRC (distinguishing between sporadic and familial forms) and discusses potential and confirmed nucleic acid biomarkers obtainable from liquid biopsies, classified by their molecular features, focusing on clinical relevance. We comment on advantageous aspects such as better patient compliance due to blood sampling being minimally invasive, the possibility to monitor mutation characteristics of sporadic and hereditary CRC in a disease showing genetic heterogeneity, and using up- or down-regulated circulating RNA markers to reveal metastasis or disease recurrence. Current difficulties and thoughts on some possible future directions are also discussed. We explore current evidence in the field pointing towards the introduction of personalized CRC management.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk colorectal cancer liquid biopsy cell-free nucleic acids biomarkers non-invasive diagnosis
Megjelenés:	Cancers. - 14 : 15 (2022), p. 1-20. -
További szerzők:	Buglyó Gergely (1980-) (genetikus) Pös, Ondrej (1990-) (biológus) Csók Ádám (1994-) (biológus) Soltész Beáta (1987-) (molekuláris biológus) Lukasz, Peter Repiská, Vanda Nagy Bálint (1956-) (molekuláris genetikus) Szemes, Tomas (1980-) (biológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM128116
035-os BibID:	(scopus)85218910548 (wos)001429631100001
Első szerző:	Torner Bernadett (molekuláris biológus)
Cím:	Construction of a miRNA Panel for Differentiating Lung Adenocarcinoma Brain Metastases and Glioblastoma / Torner Bernadett, Géczi Dóra, Klekner Álmos, Balogh István, Penyige András, Birkó Zsuzsanna
Dátum:	2025
ISSN:	2072-6694
Megjegyzések:	Abstract: Background/Objectives: Brain metastases (BM) are the most common type of intracra-nial malignant tumor and are associated with high mortality. More than 50% of BM cases origi-nate from lung cancer, and lung adenocarcinoma (LUAD) is most commonly associated with the development of BM (25%). The differential diagnosis of solitary BM and glioblastoma (GBM) ? one of the most aggressive and fatal malignant brain tumors ? remains a considerable challenge. Given the major role of microRNAs (miRNAs) in regulating gene expression, their clinical po-tential as biomarkers for tumor diagnosis and prognosis offers significant promise. Methods: Next Generation RNA Sequencing (RNA-seq) was used to assess the miRNA expression profiles of 6 LUAD-BM, 6 GBM, and 6 control (non-tumoral brain tissue samples) human brain tissue samples. miRNAs exhibiting the most significant differential expression in LUAD-BM patients in comparison to both control subjects and GBM patients were selected for validation through RT-qPCR. Results: The analysis of RNA-seq data revealed the presence of 229 differentially ex-pressed miRNAs in the comparison between LUAD-BM and control samples and 46 in the com-parison between LU-AD-BM and GBM samples. Eight miRNAs were selected for further analysis, four of which were upregulated and four downregulated, based on the significant differences in their expression levels observed between the LUAD-BM samples and the other two groups, as confirmed with the Mann-Whitney U test. A functional enrichment analysis was also conducted based on a miRNA-centered target analysis performed using the miRNet tool. To assess the di-agnostic potential of these differentially expressed miRNAs, we performed a receiver operating characteristic (ROC) curve analysis. Conclusions: A panel of eight miRNAs was identified in human brain tissue samples, exhibiting high accuracy in distinguishing LUAD-BM from both GBM and control samples.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk lung adenocarcinoma brain metastasis, glioblastoma miRNAs Next-Generation Sequencing brain tissue biomarker panel
Megjelenés:	Cancers. - 17 : 4 (2025), p. 1-23. -
További szerzők:	Géczi Dóra (1989-) (biotechnológus) Klekner Álmos (1970-) (idegsebész) Balogh István (1972-) (molekuláris biológus, genetikus) Penyige András (1954-) (molekuláris genetikus) Hádáné Birkó Zsuzsanna (1971-) (molekuláris genetikus)
Pályázati támogatás:	2017-1.2.1-NKP-2017-00002 Egyéb Bridging Fund of the Faculty of Medicine, University of Debrecen (IB) Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: