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001-es BibID:	BIBFORM045827
Első szerző:	Barabás György (sejtbiológus, molekuláris genetikus)
Cím:	Hormone-like factors influencing differentiation of Streptomyces cultures / Gy. Barabas, A. Penyige, T. Hirano
Dátum:	1994
ISSN:	0168-6445
Megjegyzések:	Actinomycetes produce and export small autoregulatory molecules, which act like prokaryotic hormones. They can promote or induce sporulation, aerial hyphae formation and antibiotic production. The mode of action of the gamma-lactone AF is partly elucidated, those of the others are not known. These autoregulators (hormones) are effective if exogenously added to culture in proper time of the life cycle and in very low concentration. Since they influence the length of idiophase where secondary metabolites are produced their study may have pratical importance.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban A-FACTOR A-FACTOR-BINDING PROTEIN; AUTOREGULATOR GTP-ASE ACTIVITY STREPTOMYCES GRISEUS
Megjelenés:	Fems Microbiology Reviews. - 14 : 1 (1994), p. 75-82. -
További szerzők:	Penyige András (1954-) (molekuláris genetikus) Hirano, Tadashi
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001-es BibID:	BIBFORM010402
Első szerző:	Chater, Keith F.
Cím:	The complex extracellular biology of Streptomyces / Keith F. Chater, Sándor Biró, Kye Joon Lee, Tracy Palmer, Hildgund Schrempf
Dátum:	2010
ISSN:	0168-6445 (Print)
Megjegyzések:	Streptomycetes, soil-dwelling mycelial bacteria that form sporulating aerial branches, have an exceptionally large number of predicted secreted proteins, including many exported via the twin-arginine transport system. Their use of noncatalytic substrate-binding proteins and hydrolytic enzymes to obtain soluble nutrients from carbohydrates such as chitin and cellulose enables them to interact with other organisms. Some of their numerous secreted proteases participate in developmentally significant extracellular cascades, regulated by inhibitors, which lead to cannibalization of the substrate mycelium biomass to support aerial growth and sporulation. They excrete many secondary metabolites, including important antibiotics. Some of these play roles in interactions with eukaryotes. Surprisingly, some antibiotic biosynthetic enzymes are extracellular. Antibiotic production is often regulated by extracellular signalling molecules, some of which also control morphological differentiation. Amphipathic proteins, assembled with the help of cellulose-like material, are required for both hyphal attachment to surfaces and aerial reproductive growth. Comparative genomic analysis suggests that the acquisition of genes for extracellular processes has played a huge part in speciation. The rare codon TTA, which is present in the key pleiotropic regulatory gene adpA and many pathway-specific regulatory genes for antibiotic production, has a particular influence on extracellular biology.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban Tat system polysaccharide degradation protease cascade secondary metabolism extracellular signalling surface-active proteins
Megjelenés:	FEMS Microbiology Reviews. - 34 : 2 (2010), p. 171-198. -
További szerzők:	Biró Sándor (1949-) (molekuláris genetikus) Lee, Kye Joon Palmer, Tracy Schrempf, Hildgund
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