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001-es BibID:	BIBFORM112371
035-os BibID:	(cikkazonosító)1129 (scopus)85160627441 (wos)000994689300001
Első szerző:	Matusovits Danica
Cím:	Paclitaxel Protects against Isoproterenol-Induced Damage in Rat Myocardium : its Heme-Oxygenase Mediated Role in Cardiovascular Research / Matusovits Danica, Murlasits Zsolt, Kupai Krisztina, Baráth Zoltán, Kang Hsu Lin, Osváth Péter, Szűcs Miklós, Priksz Dániel, Juhász Béla, Radák Zsolt, Várkonyi Tamás, Pavo Imre, Pósa Anikó
Dátum:	2023
ISSN:	2076-3921
Megjegyzések:	(1) Background: In cardiovascular applications, paclitaxel inhibits smooth muscle cell proliferation and migration and significantly reduces the occurrence of restenosis and target lesion revascularization. However, the cellular effects of paclitaxel in the myocardium are not well understood; (2) Methods: Wistar rats were divided into four groups: control (CTRL), isoproterenol (ISO) treated (1 mg/kg) and two groups treated with paclitaxel (PAC), which was administrated (10 mg/kg/day) for 5 days by gavage/per os alone or in combination (ISO + PAC) 3 weeks after ISO treatment. Ventricular tissue was harvested 24 h later for measurements of heme oxygenase (HO-1), reduced glutathione (GSH), oxidized glutathione (GSSG), superoxide dismutase (SOD), NF-?B, TNF-? and myeloperoxidase (MPO); (3) Results: HO-1 protein concentration, HO-1 activity, SOD protein concentration and total glutathione significantly decreased in response to ISO treatment. When PAC was administered in conjunction with ISO, HO-1, SOD concentration and total glutathione were not different from control levels. MPO activity, NF-?B concentration and TNF-? protein concentration were significantly increased in the ISO-only group, while the levels of these molecules were restored when PAC was co-administered; (4) Conclusions: Oral administration of PAC can maintain the expression of important antioxidants, anti-inflammatory molecules, HO-1, SOD and GSH, and suppress the production of TNF-?, MPO and NF-?B, which are involved in myocardial damage. The principal component of this cellular defense seems to be the expression of HO-1.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk paclitaxel inflammation cardioprotection
Megjelenés:	Antioxidants. - 12 : 5 (2023), p. 1-13. -
További szerzők:	Murlasits Zsolt Kupai Krisztina Baráth Zoltán (fogorvos) Kang, Hsu Lin Osváth Péter (1982-) (Urológus szakorvos) Szűcs Miklós (1966-) (urológus, andrológus) Priksz Dániel (1989-) (farmakológus) Juhász Béla (1978-) (kísérletes farmakológus) Radák Zsolt Várkonyi Tamás Pávó Imre J. Pósa Anikó
Pályázati támogatás:	ÚNKP-22-5 -SZTE-559 Egyéb GINOP_PLUSZ-2.1.1-21-2022-00083 GINOP
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001-es BibID:	BIBFORM101210
035-os BibID:	(cikkazonosító)436 (WoS)000775787700001 (Scopus)85125247473
Első szerző:	Osváth Péter (Urológus szakorvos)
Cím:	Andrological Aspects of Exercise : moderate Swimming Protects against Isoproterenol Induced Testis and Semen Abnormalities in Rats / Osváth Péter, Szűcs Miklós, Börzsei Denise, Szabó Renáta, Lesi Zelma Nadin, Turcsán Zsolt, Veszelka Médea, Sebestyén Judith, Juhász Béla, Priksz Dániel, Varga Csaba, Pósa Anikó
Dátum:	2022
ISSN:	2076-3921
Megjegyzések:	The development and progression of male infertility are closely linked to a sedentary lifestyle; however, its underlying mechanisms are not fully elucidated. Our aim was to assess the protective effects of moderate swimming exercise on the male reproductive system in isoproterenol-treated rats. Male Wistar rats were divided into five groups as follows: (1) non-interventional controls (CTRL), (2) isoproterenol-treated (ISO), (3) pre-treatment swimming training + ISO (PRE + ISO), (4) ISO + post-treatment swimming training (ISO+POST), (5) pre-treatment swimming training + ISO + post-treatment swimming training (PRE + ISO + POST) groups. Testicular oxidative stress was induced by ISO injection (1.0 mg/kg). Rats in the pre- or post-training groups were trained five days a week. At the end of the experimental period, serum testosterone levels, sperms' hyaluronan binding, and total glutathione (GSH) content, as well as myeloperoxidase activity (MPO), TNF alpha and IL6 concentrations in the testis and semen, were measured. Serum testosterone levels, sperms' hyaluronan binding, and GSH content were found to be significantly reduced, while MPO, TNF alpha and IL6 concentrations in the testis and semen were elevated after the ISO treatment compared to the CTRL group. Moderate-intensity swimming exercise effectively alleviated the negative effects of high oxidative stress. Our findings provide the first evidence that moderate-intensity swimming exercise confers sustained protection from isoproterenol-induced adverse effects on testicular inflammation.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk swimming infertility inflammation antioxidants isoproterenol
Megjelenés:	Antioxidants. - 11 : 3 (2022), p. 1-14. -
További szerzők:	Szűcs Miklós (1966-) (urológus, andrológus) Börzsei Denise Szabó Renáta Lesi, Zelma Nadin Turcsán Zsolt Veszelka Médea Sebestyén Judith Juhász Béla (1978-) (kísérletes farmakológus) Priksz Dániel (1989-) (farmakológus) Varga Csaba (orvos) Pósa Anikó
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