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1.

001-es BibID:BIBFORM132287
Első szerző:Al Ashkar, Habib (népegészségügyi szakember)
Cím:The Impact of Smoking-Associated Genetic Variants on Post-Exercise Heart Rate / Al Ashkar Habib, Kharrat Helu Nihad, Kovacs Nora, Fiatal Szilvia, Adany Roza, Piko Peter
Dátum:2025
ISSN:1661-6596 1422-0067
Megjegyzések:Smoking has a well-established impact on cardiovascular health, notably through ele- vated resting heart rate and impaired autonomic regulation?both key risk factors. While nicotine's acute effects are well documented, the influence of smoking-related genetic variants on heart rate (HR) responses remains unclear. This study investigated the asso- ciation between selected smoking-related single nucleotide polymorphisms (SNPs) and HR dynamics following physical exertion. A total of 661 Hungarian adults completed the YMCA 3 min step test, with HR measured at rest, immediately post-exercise, and during recovery at 5 and 10 min. Key indices included post-exercise HR (HRaft), HR change (?HR), maximum HR percentage (HRmax%), and heart rate recovery coefficient (HRR). Genetic analysis focused on nine SNPs previously linked to smoking behaviours, with a composite genetic risk score derived from the three most influential variants (rs2235186, rs4142041, and rs578776). Associations were examined using adjusted linear regression. No significant relationship was found between any individual SNP and resting HR. However, rs2235186, rs4142041, and rs578776 were consistently associated with elevated HRaft, increased ?HR, higher HRmax%, and slower HRR. The genetic risk score showed significant correlations with all post-exercise HR measures, suggesting a cumulative genetic effect. These findings indicate that smoking-related genetic predisposition may influence autonomic cardiovascu- lar responses to physical activity. Although resting HR remains unaffected, specific SNPs are linked to post-exercise HR dynamics and recovery, highlighting the potential value of genetic screening in personalised cardiovascular risk assessment among smokers
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
smoking
single nucleotide polymorphisms
heart rate recovery
cardiovascular risk
genetic predisposition
YMCA step test
genetic risk score
Megjelenés:International Journal Of Molecular Sciences. - 26 : 18 (2025), p. 1-17. -
További szerzők:Kharrat Helu, Nihad (1992-) Kovács Nóra (1989-) (népegészségügyi szakember) Fiatal Szilvia (1978-) (epidemiológus, népegészségügyi szakember) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Pikó Péter (1987-) (biológus)
Pályázati támogatás:GINOP-2.3.2-15-2016-00005
GINOP
TK2016-78
MTA
Hungarian Research Network?HUN-REN (TKCS-2021/32)
Egyéb
Project No. 135784 - National Research, Development, and Innovation Fund of Hungary
Egyéb
National Laboratory for Health Security Hungary (RRF-2.3.1-21-2022-00006)
Egyéb
Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences (BO/00513/23/5)
Egyéb
EKÖP-24-4 University Research Scholarship Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund
Egyéb
Stipendium Hugaricum Scholarship Program, provided by the Tempus Public Foundation and the Hungarian Government
Egyéb
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2.

001-es BibID:BIBFORM123542
035-os BibID:(Scopus)85202750993 (WoS)001307359100001
Első szerző:Al Ashkar, Habib (népegészségügyi szakember)
Cím:Association of CETP Gene Polymorphisms and Haplotypes with Acute Heart Rate Response to Exercise / Al Ashkar Habib, Kovács Nóra, Veres-Balajti Ilona, Ádány Róza, Pikó Péter
Dátum:2024
ISSN:1661-6596 1422-0067
Megjegyzések:Polymorphisms in the cholesteryl ester transfer protein (CETP) gene are known to be strongly associated with increased cardiovascular risk, primarily through their effects on the lipid profile and consequently on atherosclerotic risk. The acute heart rate response (AHRR) to physical activity is closely related to individual cardiovascular health. This study aimed to investigate the effect of CETP gene polymorphisms on AHRR. Our analysis examines the association of five single nucleotide polymorphisms (SNPs; rs1532624, rs5882, rs708272, rs7499892, and rs9989419) and their haplotypes (H) in the CETP gene with AHRR in 607 people from the Hungarian population. Individual AHRR in the present study was assessed using the YMCA 3-min step test and was estimated as the difference between resting and post-exercise heart rate, i.e., delta heart rate (Delta HR). To exclude the direct confounding effect of the CETP gene on the lipid profile, adjustments for TG and HDL-C levels, next to conventional risk factors, were applied in the statistical analyses. Among the examined five SNPs, two showed a significant association with lower Delta HR (rs1532624-C-dominant: B = -8.41, p < 0.001; rs708272-G(dominant): B = -8.33, p < 0.001) and reduced the risk of adverse AHRR (rs1532624-C-dominant: OR = 0.44, p = 0.004; rs708272-G(dominant): OR = 0.43, p = 0.003). Among the ten haplotypes, two showed significant association with lower Delta HR (H3-CAGCA: B = -6.81, p = 0.003; H9-CGGCG: B = -14.64, p = 0.015) and lower risk of adverse AHRR (H3-CAGCA: OR = 0.58, p = 0.040; H9-CGGCG: OR = 0.05, p = 0.009) compared to the reference haplotype (H1-AGACG). Our study is the first to report a significant association between CETP gene polymorphisms and AHRR. It also confirms that the association of the CETP gene with cardiovascular risk is mediated by changes in heart rate in response to physical activity, in addition to its effect on lipid profile.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
cardiovascular risk
haplotype
acute heart rate response
cholesteryl ester transfer protein
genomics
Megjelenés:International Journal Of Molecular Sciences. - 25 : 16 (2024), p. 1-10.-
További szerzők:Kovács Nóra (1989-) (népegészségügyi szakember) Veres-Balajti Ilona (1965-) (gyógytornász, egészségfejlesztő) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Pikó Péter (1987-) (biológus)
Pályázati támogatás:GINOP-2.3.2-15-2016-00005
GINOP
TK2016-78
MTA
Hungarian Research Network-HUN-REN (TKCS-2021/32)
Egyéb
National Research, Development, and Innovation Fund of Hungary K_20 programme
Egyéb
National Laboratory for Health Security Hungary (RRF-2.3.1-21-2022-00006)
Egyéb
ÚNKP-23-5-DE-494
Egyéb
Janos Bolyai Research Scholarship (BO/00513/23/5)
MTA
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DOI
Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM132510
035-os BibID:(scopus)105018893148 (wos)001593619000001
Első szerző:Koroknai Viktória (molekuláris biológus)
Cím:Cytokine and Chemokine-Associated Signatures Underlying Dermal Invasion and Skin Metastasis in Melanoma / Koroknai Viktória, Szász István, Várvölgyi Tünde, Emri Gabriella, Fodor Ádám, Balázs Margit
Dátum:2025
ISSN:1661-6596 1422-0067
Megjegyzések:Metastatic spread remains the primary cause of mortality in melanoma. Our aim was to investigate the role of dermal endothelial cells in modulating melanoma cell invasiveness and cytokine/chemokine pattern. Primary melanoma cell lines were co-cultured with human dermal endothelial cells and assessed using Matrigel invasion assays. Invasive and non-invasive subpopulations were separated for gene expression analyses, and candidate molecules were further evaluated in patient tissue and plasma samples. Co-culture of melanoma and dermal endothelial cells revealed altered expression of several cytokine receptor genes (CCR5, CXCR7, IL1RAPL2, IL4R, IL6ST, IL18R1, IL22RA2, TNFRSF10A, TNFRSF11B, and TNFRSF21). Analysis of clinical melanoma samples showed significant downregulation of IL1RAPL2 and TNFRSF10A in cutaneous metastases, whereas IL6ST expression correlated with Breslow thickness of the primary tumor rather than metastatic site. Proteome profiling of dermal endothelial cells revealed alterations in Midkine, GRO?, MIP-3?, IL-8, and SDF-1 following co-culture with melanoma cells. Plasma measurements in melanoma patients confirmed elevated Midkine levels in skin metastases and decreased MIP-3? in metastatic disease. These results highlight potential cytokine and chemokine-mediated pathways involved in melanoma dermal invasion and cutaneous metastasis. While some findings did not reach statistical significance, concordant trends between in vitro and patient-derived data suggest their relevance and warrant further investigation in larger cohorts.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
melanoma
metastasis
dermal endothelium
cytokines
chemokines
Midkine
IL1RAPL2
TNFRSF10A
IL6ST
Megjelenés:International Journal Of Molecular Sciences. - 26 : 19 (2025), p. 1-14. -
További szerzők:Szász István (1985-) (Ph.D hallgató) Várvölgyi Tünde (1984-) (bőrgyógyász) Emri Gabriella (1972-) (bőrgyógyász, allergológus, onkológus) Fodor Ádám Balázs Margit (1952-) (sejtbiológus, molekuláris genetikus)
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Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM112106
035-os BibID:(scopus)85160449212 (wos)000997506400001
Első szerző:Koroknai Viktória (molekuláris biológus)
Cím:Gene Expression Changes in Cytokine and Chemokine Receptors in Association with Melanoma Liver Metastasis / Koroknai Viktória, Szász István, Balázs Margit
Dátum:2023
ISSN:1422-0067
Megjegyzések:Abstract: Cytokines and chemokines (chemotactic cytokines) are soluble extracellular proteins that bind to specific receptors and play an integral role in the cell-to-cell signaling network. In addition, they can promote the homing of cancer cells into different organs. We investigated the potential relationship between human hepatic sinusoidal endothelial cells (HHSECs) and several melanoma cell lines for the expression of chemokine and cytokine ligands and receptor expression during the invasion of melanoma cells. In order to identify differences in gene expression related to invasion, we selected invasive and non-invasive subpopulations of cells after co-culturing with HHSECs and identified the gene expression patterns of 88 chemokine/cytokine receptors in all cell lines. Cell lines with stable invasiveness and cell lines with increased invasiveness displayed distinct profiles of receptor genes. Cell lines with increased invasive capacity after culturing with conditioned medium showed a set of receptor genes (CXCR1, IL1RL1, IL1RN, IL3RA, IL8RA, IL11RA, IL15RA, IL17RC, andIL17RD) with significantly different expressions. It is very important to emphasize that we detected significantly higher IL11RA gene expression in primary melanoma tissues with liver metastasis as well, compared to those without metastasis. In addition, we assessed protein expression in endothelial cells before and after co-culturing them with melanoma cell lines by applying chemokine and cytokine proteome arrays. This analysis revealed 15 differentially expressed proteins (includingCD31, VCAM-1, ANGPT2, CXCL8, and CCL20) in the hepatic endothelial cells after co-culture with melanoma cells. Our results clearly indicate the interaction between liver endothelial and melanoma cells. Furthermore, we assume that overexpression of the IL11RA gene may play a key role in organ-specific metastasis of primary melanoma cells to the liver (10) (PDF) Gene Expression Changes in Cytokine and Chemokine Receptors in Association with Melanoma Liver Metastasis. Available from: https://www.researchgate.net/publication/370889463_Gene_Expression_Changes_in_Cytokine_and_Chemokine_Receptors_in_Association_with_Melanoma_Liver_Metastasis#fullTextFileContent [accessed May 30 2023].
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
malignant melanoma
liver metastasis
cytokines
IL11RA
hepatic endothelial cells
Megjelenés:International Journal Of Molecular Sciences. - 24 : 10 (2023), p. 1-13. -
További szerzők:Szász István (1985-) (Ph.D hallgató) Balázs Margit (1952-) (sejtbiológus, molekuláris genetikus)
Pályázati támogatás:GINOP-2.3.2-15-2016-00005
GINOP
TK2016-78
Egyéb
ÚNKP-22-4
Egyéb
ÚNKP-22-4-II-DE-86
Egyéb
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Intézményi repozitóriumban (DEA) tárolt változat
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5.

001-es BibID:BIBFORM119418
035-os BibID:(Scopus)85189091222 (WoS)001193452500001
Első szerző:Pikó Péter (biológus)
Cím:Genetic Background of Acute Heart Rate Response to Exercise / Péter Pikó, Habib Al Ashkar, Nóra Kovács, Ilona Veres-Balajti, Róza Ádány
Dátum:2024
ISSN:1422-0067
Megjegyzések:The acute heart rate response (AHRR) to physical activity, which refers to the change in heart rate during and after exercise, has been associated with cardiovascular and all-cause mortality. Previous studies have shown that AHRR is significantly determined by genetics in addition to environmental and lifestyle factors. The aim of this study was to investigate the genetic background of AHRR by analysing ten single nucleotide polymorphisms (SNPs) associated with leisure-time physical activity (LTPA) in 620 samples from the Hungarian population. The AHRR can be characterised as the difference between post-exercise and resting heart rate, i.e., the delta heart rate (?HR) defined by the YMCA 3 min step test, with a lower value indicating better cardiovascular fitness. The association of SNPs with ?HR was analysed both separately and in combination using an optimised polygenic score (oPGS). The results showed that five SNPs (rs10252228, rs459465, rs6022999, rs8097348, and rs12405556) had at least nominally significant (p < 0.05) individual associations with ?HR. After optimizing the PGS, a cumulative effect was observed for eight SNPs (rs6022999, rs12405556, rs459465, rs10252228, rs8097348, rs10887741, rs12612420, and rs7023003) that had a strong and statistically significant association with ?HR (B = ?2.51, 95% CI: ?3.46??1.76; p = 2.99 ? 10?9). Of the four main domains of physical activity, the oPGS showed a significant positive association only with LTPA (B = 84.60; 95%CI: 25.23?143.98; p = 0.005). In conclusion, our results suggest that the SNPs we investigated influence individual leisure-time physical activity, mediated by their effects on the acute heart rate response.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
acute heart rate response
cardiorespiratory fitness
YMCA 3 min step test
optimised polygenic score
single nucleotide polymorphism
leisure-time physical activity
Megjelenés:International Journal Of Molecular Sciences. - 25 : 6 (2024), p. 1-12. -
További szerzők:Al Ashkar, Habib (1998-) (népegészségügyi szakember) Kovács Nóra (1989-) (népegészségügyi szakember) Veres-Balajti Ilona (1965-) (gyógytornász, egészségfejlesztő) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
Pályázati támogatás:GINOP-2.3.2-15-2016-00005
GINOP
TK2016-78
MTA
TKCS-2021/32
Egyéb
135784
OTKA
National Research, Development, and Innovation Office (NKFIH) RRF-2.3.1-21-2022-00006
Egyéb
ÚNKP-23-5-DE-494
Egyéb
BO/00513/23/5
MTA
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

6.

001-es BibID:BIBFORM114677
035-os BibID:(scopus)85164039480 (wos)001015071200001
Első szerző:Pikó Péter (biológus)
Cím:Association of CETP Gene Polymorphisms and Haplotypes with Cardiovascular Risk / Piko Peter, Jenei Tibor, Kosa Zsigmond, Sandor Janos, Kovacs Nora, Seres Ildiko, Paragh Gyorgy, Adany Roza
Dátum:2023
ISSN:1422-0067
Megjegyzések:Cholesteryl ester transfer protein (CETP) is known to influence HDL-C levels, potentially altering the profile of HDL subfractions and consequently cardiovascular risk (CVR). This study aimed to investigate the effect of five single-nucleotide polymorphisms (SNPs; rs1532624, rs5882, rs708272, rs7499892, and rs9989419) and their haplotypes (H) in the CETP gene on 10-year CVR estimated by the Systematic Coronary Risk Evaluation (SCORE), the Framingham Risk Score for Coronary Heart Disease (FRSCHD) and Cardiovascular Disease (FRSCVD) algorithms. Adjusted linear and logistic regression analyses were used to investigate the association of SNPs and 10 haplotypes (H1-H10) on 368 samples from the Hungarian general and Roma populations. The T allele of rs7499892 showed a significant association with increased CVR estimated by FRS. H5, H7, and H8 showed a significant association with increased CVR based on at least one of the algorithms. The impact of H5 was due to its effect on TG and HDL-C levels, while H7 showed a significant association with FRSCHD and H8 with FRSCVD mediated by a mechanism affecting neither TG nor HDL-C levels. Our results suggest that polymorphisms in the CETP gene may have a significant effect on CVR and that this is not mediated exclusively by their effect on TG and HDL-C levels but also by presently unknown mechanisms.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Framingham Risk Score
HDL subfraction profile
Systematic Coronary Risk Evaluation
cholesteryl ester transfer protein
haplotype
high-density lipoprotein cholesterol
single-nucleotide polymorphism
Megjelenés:International Journal Of Molecular Sciences. - 24 : 12 (2023), p. 1-16. -
További szerzők:Jenei Tibor (1963-) (programtervező informatikus) Kósa Zsigmond (1953-) (orvos) Sándor János (1966-) (orvos-epidemiológus) Kovács Nóra (1989-) (népegészségügyi szakember) Seres Ildikó (1954-) (biokémikus) Paragh György (1953-) (belgyógyász) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
Pályázati támogatás:GINOP-2.3.2-15-2016-00005
GINOP
135784
OTKA
TK2016-78
Egyéb
TKCS-2021/32
Egyéb
ÚNKP-22-4-II-DE-268
Egyéb
RRF-2.3.1-21-2022-00006
Egyéb
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

7.

001-es BibID:BIBFORM114678
035-os BibID:(scopus)85170209245 (wos)001060602800001
Első szerző:Pikó Péter (biológus)
Cím:Association of HDL Subfraction Profile with the Progression of Insulin Resistance / Piko Peter, Jenei Tibor, Kosa Zsigmond, Sandor Janos, Kovacs Nora, Seres Ildiko, Paragh Gyorgy, Adany Roza
Dátum:2023
ISSN:1422-0067
Megjegyzések:Type 2 diabetes mellitus (T2DM) is a major global public health problem, as it is associated with increased morbidity, mortality, and healthcare costs. Insulin resistance (IR) is a condition characterized by disturbances in carbohydrate and lipid metabolism that precedes T2DM. The aim of the present study was to investigate the association between HDL and its subfraction profile and the progression of IR, as assessed by the Homeostatic Model Assessment for IR (HOMA-IR) index, and to define cut-off values to identify an increased risk of IR. Individuals with a HOMA-IR greater than 3.63 were considered to have IR. The HDL subfractions were separated using the Lipoprint system, which identifies ten subfractions (HDL-1-10) in three subclasses as large (HDL-L), intermediate (HDL-I) and small (HDL-S). Analyses were performed on samples from 240 individuals without IR and 137 with IR from the Hungarian general and Roma populations. The HDL-1 to -6 subfractions and the HDL-L and -I classes showed a significant negative association with the progression and existence of IR. Among them, HDL-2 (B = -40.37, p = 2.08 ? 10-11) and HDL-L (B = -14.85, p = 9.52 ? 10-10) showed the strongest correlation. The optimal threshold was found to be 0.264 mmol/L for HDL-L and 0.102 mmol/L and above for HDL-2. Individuals with HDL-L levels below the reference value had a 5.1-fold higher risk of IR (p = 2.2 ? 10-7), while those with HDL-2 levels had a 4.2-fold higher risk (p = 3.0 ? 10-6). This study demonstrates that the HDL subfraction profile (especially the decrease in HDL-2 and -L) may be a useful marker for the early detection and intervention of atherogenic dyslipidemia in subjects with impaired glucose and insulin metabolism.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
insulin resistance
HDL subfraction profile
HDL-2
large HDL
cut-off points
HOMA-IR
diabetes
high-density lipoprotein cholesterol
Megjelenés:International Journal Of Molecular Sciences. - 24 : 17 (2023), p. 1-13. -
További szerzők:Jenei Tibor (1963-) (programtervező informatikus) Kósa Zsigmond (1953-) (orvos) Sándor János (1966-) (orvos-epidemiológus) Kovács Nóra (1989-) (népegészségügyi szakember) Seres Ildikó (1954-) (biokémikus) Paragh György (1953-) (belgyógyász) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
Pályázati támogatás:GINOP-2.3.2-15-2016-00005
GINOP
135784
OTKA
TK2016-78
Egyéb
TKCS-2021/32
Egyéb
ÚNKP-22-4-II-DE-268
Egyéb
RRF-2.3.1-21-2022-00006
Egyéb
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

8.

001-es BibID:BIBFORM110622
035-os BibID:(scopus)85151435418 (wos)000957873700001
Első szerző:Pikó Péter (biológus)
Cím:Genetic Background of Metabolically Healthy and Unhealthy Obesity Phenotypes in Hungarian Adult Sample Population / Piko Peter, Llanaj Erand, Nagy Karoly, Adany Roza
Dátum:2023
ISSN:1422-0067
Megjegyzések:A specific phenotypic variant of obesity is metabolically healthy (MHO), which is characterized by normal blood pressure and lipid and glucose profiles, in contrast to the metabolically unhealthy variant (MUO). The genetic causes underlying the differences between these phenotypes are not yet clear. This study aims to explore the differences between MHO and MUO and the contribution of genetic factors (single nucleotide polymorphisms?SNPs) in 398 Hungarian adults (81 MHO and 317 MUO). For this investigation, an optimized genetic risk score (oGRS) was calculated using 67 SNPs (related to obesity and to lipid and glucose metabolism). Nineteen SNPs were identified whose combined effect was strongly associated with an increased risk of MUO (OR = 1.77, p < 0.001). Four of them (rs10838687 in MADD, rs693 in APOB, rs1111875 in HHEX, and rs2000813 in LIPG) significantly increased the risk of MUO (OR = 1.76, p < 0.001). Genetic risk groups based on oGRS were significantly associated with the risk of developing MUO at a younger age. We have identified a cluster of SNPs that contribute to the development of the metabolically unhealthy phenotype among Hungarian adults suffering from obesity. Our findings emphasize the significance of considering the combined effect(s) of multiple genes and SNPs in ascertaining cardiometabolic risk in obesity in future genetic screening programs.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
optimized genetic risk score
metabolically unhealthy obesity
metabolically healthy obesity
Hungarian population
Lipid metabolism
Glucose metabolism
Megjelenés:International Journal Of Molecular Sciences. - 24 : 6 (2023), p. 1-16. -
További szerzők:Llanaj, Erand (1988-) (táplálkozási epidemiológus) Nagy Károly (1986-) (népegészségügyi felügyelő) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
Pályázati támogatás:GINOP-2.3.2-15-2016-00005
GINOP
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

9.

001-es BibID:BIBFORM109123
035-os BibID:(WoS)000947319300001 (Scopus)85149877208
Első szerző:Pikó Péter (biológus)
Cím:Genetic Determinants of Leisure-Time Physical Activity in the Hungarian General and Roma Populations / Pikó Péter, Bácsné Bába Éva, Kósa Zsigmond, Sándor János, Kovács Nóra, Bács Zoltán, Ádány Róza
Dátum:2023
ISSN:1422-0067
Megjegyzések:Leisure-time physical activity (LTPA) is one of the modifiable lifestyle factors that play an important role in the prevention of non-communicable (especially cardiovascular) diseases. Certain genetic factors predisposing to LTPA have been previously described, but their effects and applicability on different ethnicities are unknown. Our present study aims to investigate the genetic background of LTPA using seven single nucleotide polymorphisms (SNPs) in a sample of 330 individuals from the Hungarian general (HG) and 314 from the Roma population. The LTPA in general and three intensity categories of it (vigorous, moderate, and walking) were examined as binary outcome variables. Allele frequencies were determined, individual correlations of SNPs to LTPA, in general, were determined, and an optimized polygenetic score (oPGS) was created. Our results showed that the allele frequencies of four SNPs differed significantly between the two study groups. The C allele of rs10887741 showed a significant positive correlation with LTPA in general (OR = 1.48, 95% CI: 1.12?1.97; p = 0.006). Three SNPs (rs10887741, rs6022999, and rs7023003) were identified by the process of PGS optimization, whose cumulative effect shows a strong significant positive association with LTPA in general (OR = 1.40, 95% CI: 1.16?1.70; p < 0.001). The oPGS showed a significantly lower value in the Roma population compared with the HG population (oPGSRoma: 2.19 SD: 0.99 vs. oPGSHG: 2.70 SD: 1.06; p < 0.001). In conclusion, the coexistence of genetic factors that encourage leisure-time physical activity shows a more unfavorable picture among Roma, which may indirectly contribute to their poor health status.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
genetics
leisure-time physical activity
polygenic score
Roma population
Hungarian population
Megjelenés:International Journal Of Molecular Sciences. - 24 : 5 (2023), p. 1-14. -
További szerzők:Bácsné Bába Éva (1968-) (bölcsésztanár, szakközgazda) Kósa Zsigmond (1953-) (orvos) Sándor János (1966-) (orvos-epidemiológus) Kovács Nóra (1989-) (népegészségügyi szakember) Bács Zoltán (1969-) (agrármérnök) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
Pályázati támogatás:GINOP-2.3.2- 15-2016-00005
Egyéb
TK2016-78
Egyéb
TKCS-2021/32
Egyéb
135784
OTKA
ÚNKP-22-4-II-DE-268
Egyéb
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

10.

001-es BibID:BIBFORM131979
035-os BibID:(scopus)105014620521 (wos)001559699200001
Első szerző:Szász István (Ph.D hallgató)
Cím:Circulating Calprotectin Distinguishes Metastatic Melanoma and Predicts Liver Metastasis / Szász István, Koroknai Viktória, Várvölgyi Tünde, Emri Gabriella, Szabó Imre Lőrinc, Balázs Margit
Dátum:2025
ISSN:1661-6596 1422-0067
Megjegyzések:Calprotectin, a heterodimer of the S100A8 and S100A9 proteins, has been implicated in cancer-related inflammation and metastasis. Its role in melanoma progression, particularly in organ-specific metastasis, remains underexplored. In this retrospective study, plasma calprotectin levels were measured in 201 individuals, including healthy controls (n = 22), melanoma patients without evidence of metastasis (n = 71), and patients with metastatic melanoma (n = 108). Calprotectin concentrations were determined using the ELISA assay. Receiver operating characteristic (ROC) curve analyses were used to evaluate its diagnostic value, both alone and in combination with established biomarkers S100B and LDH. Plasma calprotectin levels were significantly elevated in patients with metastatic melanoma compared to non-metastatic patients (p < 0.001). Calprotectin showed moderate diagnostic value (AUC = 0.672), which improved to 0.755 when combined with S100B and LDH. Organ-specific analysis revealed that patients with liver metastases exhibited the highest calprotectin concentrations, with good discriminatory power (AUC = 0.710). No significant association was found between calprotectin levels and the type of metastasis identified (lymphatic vs. hematogenous). Logistic regression analysis showed that calprotectin levels above 2728 ng/mL were associated with a 7.4-fold increased risk of liver metastasis. Calprotectin is a promising blood-based biomarker that may enhance the detection of metastatic melanoma, particularly in cases with liver involvement. These findings suggest that calprotectin could be integrated into multivariable prediction models to improve risk stratification in clinical practice.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
melanoma
organ specific metastasis
liver metastasis
calprotectin
liquid biopsy
S100B and LDH
biomarker
Megjelenés:International Journal Of Molecular Sciences. - 26 : 16 (2025), p. 1-9. -
További szerzők:Koroknai Viktória (1986-) (molekuláris biológus) Várvölgyi Tünde (1984-) (bőrgyógyász) Emri Gabriella (1972-) (bőrgyógyász, allergológus, onkológus) Szabó Imre Lőrinc (1987-) (általános orvos) Balázs Margit (1952-) (sejtbiológus, molekuláris genetikus)
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

11.

001-es BibID:BIBFORM128087
035-os BibID:(WoS)001430195600001 (Scopus)85218852728
Első szerző:Szász István (Ph.D hallgató)
Cím:Association of Plasma Lipid Patterns and LDL Cholesterol Levels with Breslow Thickness and Ulceration in Melanoma Patients / Szász István, Koroknai Viktória, Várvölgyi Tünde, Pál László, Szűcs Sándor, Pikó Péter, Emri Gabriella, Janka Eszter, Szabó Imre Lőrinc, Ádány Róza, Balázs, Margit
Dátum:2025
ISSN:1661-6596 1422-0067
Tárgyszavak:idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:International Journal Of Molecular Sciences. - 26 : 4 (2025), p. 1-11. -
További szerzők:Koroknai Viktória (1986-) (molekuláris biológus) Várvölgyi Tünde (1984-) (bőrgyógyász) Pál László (1987-) (népegészségügyi szakember, egészségfejlesztő) Szűcs Sándor (1958-) (biokémikus, vegyész) Pikó Péter (1987-) (biológus) Emri Gabriella (1972-) (bőrgyógyász, allergológus, onkológus) Janka Eszter Anna (1989-) (bőrgyógyász, népegészségügyi szakember) Szabó Imre Lőrinc (1987-) (általános orvos) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Balázs Margit (1952-) (sejtbiológus, molekuláris genetikus)
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

12.

001-es BibID:BIBFORM120546
035-os BibID:(Scopus)85191414953 (WoS)001210096400001
Első szerző:Szász István (Ph.D hallgató)
Cím:Identification of Plasma Lipid Alterations Associated with Melanoma Metastasis / István Szász, Viktória Koroknai, Tünde Várvölgyi, László Pál, Sándor Szűcs, Péter Pikó, Gabriella Emri, Eszter Janka, Imre Lőrinc Szabó, Róza Ádány, Margit Balázs
Dátum:2024
ISSN:1422-0067
Megjegyzések:The aim of this study was to apply a state-of-the-art quantitative lipidomic profiling platform to uncover lipid alterations predictive of melanoma progression. Our study included 151 melanoma patients; of these, 83 were without metastasis and 68 with metastases. Plasma samples were analyzed using a targeted Lipidyzer (TM) platform, covering 13 lipid classes and over 1100 lipid species. Following quality control filters, 802 lipid species were included in the subsequent analyses. Total plasma lipid contents were significantly reduced in patients with metastasis. Specifically, levels of two out of the thirteen lipid classes (free fatty acids (FFAs) and lactosylceramides (LCERs)) were significantly decreased in patients with metastasis. Three lipids (CE(12:0), FFA(24:1), and TAG47:2-FA16:1) were identified as more effective predictors of melanoma metastasis than the well-known markers LDH and S100B. Furthermore, the predictive value substantially improved upon combining the lipid markers. We observed an increase in the cumulative levels of five lysophosphatidylcholines (LPC(16:0); LPC(18:0); LPC(18:1); LPC(18:2); LPC(20:4)), each individually associated with an elevated risk of lymph node metastasis but not cutaneous or distant metastasis. Additionally, seventeen lipid molecules were linked to patient survival, four of which (CE(12:0), CE(14:0), CE(15:0), SM(14:0)) overlapped with the lipid panel predicting metastasis. This study represents the first comprehensive investigation of the plasma lipidome of melanoma patients to date. Our findings suggest that plasma lipid profiles may serve as important biomarkers for predicting clinical outcomes of melanoma patients, including the presence of metastasis, and may also serve as indicators of patient survival.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:International Journal Of Molecular Sciences. - 25 : 8 (2024), p. 1-15. -
További szerzők:Koroknai Viktória (1986-) (molekuláris biológus) Várvölgyi Tünde (1984-) (bőrgyógyász) Pál László (1987-) (népegészségügyi szakember, egészségfejlesztő) Szűcs Sándor (1958-) (biokémikus, vegyész) Pikó Péter (1987-) (biológus) Emri Gabriella (1972-) (bőrgyógyász, allergológus, onkológus) Janka Eszter Anna (1989-) (bőrgyógyász, népegészségügyi szakember) Szabó Imre Lőrinc (1987-) (általános orvos) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Balázs Margit (1952-) (sejtbiológus, molekuláris genetikus)
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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