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001-es BibID:	BIBFORM096080
035-os BibID:	(cikkazonosító)16652 (WOS)000686690900023 (Scopus)85113167051 (PMID)34404848
Első szerző:	Tóth Noémi
Cím:	The development of L-type Ca2+ current mediated alternans does not depend on the restitution slope in canine ventricular myocardium / Tóth Noémi, Szlovák Jozefina, Kohajda Zsófia, Bitay Gergő, Veress Roland, Horváth Balázs, Papp Julius Gy., Varró András, Nagy Norbert
Dátum:	2021
ISSN:	2045-2322
Megjegyzések:	Cardiac alternans have crucial importance in the onset of ventricular fibrillation. The early explanation for alternans development was the voltage-driven mechanism, where the action potential (AP) restitution steepness was considered as crucial determining factor. Recent results suggest that restitution slope is an inadequate predictor for alternans development, but several studies still claim the role of membrane potential as underlying mechanism of alternans. These controversial data indicate that the relationship of restitution and alternans development is not completely understood. APs were measured by conventional microelectrode technique from canine right ventricular papillary muscles. Ionic currents combined with fluorescent measurements were recorded by patch-clamp technique. APs combined with fluorescent measurements were monitored by sharp microelectrodes. Rapid pacing evoked restitution-independent AP duration (APD) alternans. When non-alternating AP voltage command was used, Ca2+i-transient (CaT) alternans were not observed. When alternating rectangular voltage pulses were applied, CaT alternans were proportional to ICaL amplitude alternans. Selective ICaL inhibition did not influence the fast phase of APD restitution. In this study we found that ICaL has minor contribution in shaping the fast phase of restitution curve suggesting that ICaL?if it plays important role in the alternans mechanism?could be an additional factor that attenuates the reliability of APD restitution slope to predict alternans.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Scientific Reports. - 11 : 1 (2021), p. 16652. -
További szerzők:	Szlovák Jozefina Kohajda Zsófia Bitay Gergő Veress Roland (1992-) (molekuláris biológus) Horváth Balázs (1981-) (élettanász) Papp Gy. Julius (Szeged) Varró András (1954-) (farmakológus, klinikai farmakológus) Nagy Norbert (1977-) (kísérletes farmakológus)
Pályázati támogatás:	FK128116 OTKA ÚNKP-20-5-SZTE-165 Egyéb ÚNKP-20-3-SZTE-126 Egyéb GINOP-2.3.2-15-2016-00006 GINOP EFOP-3.6.2-16-2017-0006 EFOP
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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