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001-es BibID:	BIBFORM054358
Első szerző:	Nagy Béla Jr. (labordiagnosztikai szakorvos)
Cím:	Elevated human epididymis protein 4 concentrations in chronic kidney disease / Béla Nagy Jr., Zoárd T. Krasznai, Heidi Balla, Mária Csobán, Péter Antal-Szalmás, Zoltán Hernádi, János Kappelmayer
Dátum:	2012
ISSN:	0004-5632
Megjegyzések:	Background: Human epididymis protein 4 (HE4) has recently become an available tumour biomarker for detecting ovariancancer along with the standard cancer antigen 125 (CA125). However, it is unknown if the levels of HE4 and CA125 may bealtered in subjects who have impaired renal function with no ovarian disorders.Methods: In 113 female patients at different stages of chronic kidney disease (CKD) with no ovarian and lung cancer and 68subjects with normal renal and ovarian function, HE4 and CA125 concentrations were analysed by using chemiluminescentmicroparticle immunoassay (Architectw, Abbott) and electrochemiluminescent immunoassay (Modular E170w, Roche),respectively. Renal function was evaluated by measuring serum creatinine and urea concentrations (Cobas Integra-800w,Roche). Estimated glomerular filtration rate (eGFR in mL/min/1.73 m2) was calculated by the 4v-MDRD formula.Results: Significantly increased HE4 concentrations (P, 0.0001) were found in individuals with differently decreased eGFRvalues (,90 mL/min/1.73 m2) compared with clinical controls. CA125 serum concentration was higher than normal insubjects with CKD3 (eGFR ? 30?59 mL/min/1.73 m2), but significant elevation (P ? 0.006) in CA125 concentrations wasseen only in those who had severe renal failure (CKD4-5; eGFR , 30 mL/min/1.73 m2). These tendencies were independent ofage in our study cohort, and seemed to be more evident among women in premenopausal status.Conclusions: HE4 concentrations may be elevated in CKD patients with no ovarian and lung cancer. Thus, HE4 results shouldbe interpreted cautiously in women with renal disorders.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Annals of Clinical Biochemistry. - 49 : 4 (2012), p. 377-380. -
További szerzők:	Krasznai Zoárd Tibor (1973-) (szülész-nőgyógyász, gyermeknőgyógyász) Balla Heidi Csobán Mária Antal-Szalmás Péter (1968-) (laboratóriumi szakorvos) Hernádi Zoltán (1948-) (szülész-nőgyógyász, klinikai onkológus) Kappelmayer János (1960-) (laboratóriumi szakorvos)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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