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001-es BibID:BIBFORM015607
035-os BibID:15003543
Első szerző:Felszeghy Szabolcs Béla (fogorvos, anatómus, kötőszövetbiológus)
Cím:Expression of aquaporin isoforms during human and mouse tooth development / S. Felszeghy, L. Modis, P. Nemeth, G. Nagy, T. Zelles, P. Agre, J. Laurikkala, O. Fejerskov, I. Thesleff, S. Nielsen
ISSN:0003-9969 (Linking)
Megjegyzések:Previously, we described the development of hyaluronan (HA) deposition in humantooth germ tissues that are consistent with water transport in different stagesof tooth development. The aquaporins (AQP) constitute a family of membrane waterchannels that are expressed in many organs. However, there are no data availableabout the expression pattern of aquaporin water channels in dental structures. Inthe present study we have characterised the expression of six different aquaporinisoforms (AQP1-5, AQP-9) in developing human and mouse tooth germs byimmunohistochemistry using isoform specific antibodies. In the "bell stage" AQP1was expressed in endothelial cells of small vessels whereas no other structuresof the tooth primordial were labeled. AQP2, AQP3 and AQP9 immunoreactivity wasnot observed in tooth germs, whereas strong AQP4 and AQP5 expression was observedin dental lamina, inner enamel epithelium, stratum intermedium, stellatereticulum and the outer enamel epithelium. Oral epithelium also exhibited AQP4and AQP5 immunolabeling. During development of the matrices of the dental hardtissues AQP4 and AQP5 immunostaining was observed in the odontoblasts and theirprocesses, as well as in the secretory ameloblast and their apical processes.Immunolabeling controls were negative. In conclusion, AQP4 and AQP5 are expressedin tooth germ tissues in early development in cells that previously have beenshown to express HA and/or CD44, indicating that AQP water channels may play arole for ECM hydration during tooth development.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
0 (Aquaporins)
Mouth Mucosa/metabolism
Tooth/*growth & development/metabolism
egyetemen (Magyarországon) készült közlemény
Tooth Germ/growth & development/metabolism
Megjelenés:Archives of oral biology. - 49 : 4 (2004), p. 247-257. -
További szerzők:Módis László (1939-) (anatómus, kötőszövetbiológus) Németh Péter Nagy G. Zelles Tivadar Agre, P. Laurikkala, J. Fejerskov, O. Thesleff, Irma Nielsen, S.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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