Összesen 3 találat.


001-es BibID:BIBFORM015615
035-os BibID:10946767
Első szerző:Felszeghy Szabolcs Béla (fogorvos, anatómus, kötőszövetbiológus)
Cím:Quantitative image analysis of hyaluronan expression in human tooth germs / Felszeghy S., Hyttinen, M., Tammi, R., Tammi, M., Modis L.
ISSN:0909-8836 (Linking)
Megjegyzések:The expression of hyaluronan in human tooth germs was studied by using abiotinylated hyaluronan-binding complex and quantitative digital image analysis.At the cap stage, dental papilla exhibited a moderate staining, while intensereaction was observed in the apical portion of presecretory ameloblasts, stellatereticulum, and in dental basement membrane. When the enamel and dentine matricesstarted to develop, a strong hyaluronan reaction was evident in the young enameland the apical portion of secretory ameloblasts. No hyaluronan could be detectedin the secretory ameloblasts and enamel matrix of the early (9-wk-old) post-natalstage. It is concluded that hyaluronan may play a transitory role in the earlyphase of the development of the enamel matrix organization. A very weak signalwas observed in the wall of dentin tubules, whereas the rest of the dentinematrix was not stained. The odontoblasts and the pulp were also moderatelystained, and these reactions gradually decreased with age, suggesting thathyaluronan may also contribute to the development of dentine matrix and pulp.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
0 (Extracellular Matrix Proteins)
9004-61-9 (Hyaluronic Acid)
Dental Papilla/embryology/metabolism
Embryonic and Fetal Development
Enamel Organ/embryology/metabolism
Extracellular Matrix Proteins/metabolism
Hyaluronic Acid/*metabolism
Image Processing, Computer-Assisted
Immunoenzyme Techniques
Protein Binding
Tooth Germ/*embryology/*metabolism
egyetemen (Magyarországon) készült közlemény
Megjelenés:European journal of oral sciences. - 108 : 4 (2000), p. 320-326. -
További szerzők:Hyttinen, Mikka Tammi, Raija (kutatóorvos) Tammi, Markku (kutatóorvos) Módis László (1939-) (anatómus, kötőszövetbiológus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat


001-es BibID:BIBFORM015611
035-os BibID:11451408
Első szerző:Felszeghy Szabolcs Béla (fogorvos, anatómus, kötőszövetbiológus)
Cím:The distribution pattern of the hyaluronan receptor CD44 during human toothdevelopment / Szabolcs Felszeghy, László Módis, Markku Tammi, Raija Tammi
ISSN:0003-9969 (Linking)
Megjegyzések:The aim was to investigate the expression pattern of the major cell-surfacehyaluronan receptor CD44, as there are no existing data on its presence orabsence in human dental structures at different developmental stages.Immunohistochemical localization of CD44 was studied using a monoclonal antibody,H3, that specifically recognizes an epitope in the common backbone of all CD44isoforms. The dental lamina displayed a strong CD44 signal; the external enamelepithelium was negative. In the coronal region of the tooth germ the presecretoryameloblasts showed an intense reaction whereas the less differentiated innerenamel epithelial cells showed no signal at the cervical loop where they meet theexternal enamel epithelium. In the stellate reticulum a moderate reaction wasdetected. The secretory ameloblasts and the stratum intermedium showed a strongcell-surface CD44 signal. A strong signal was also observed on the odontoblastsand their processes. In the pulp, close to the odontoblastic layer, weaklabelling was seen in the walls of capillary vessels. The distribution of CD44 inthe human tooth germ corresponds to that of hyaluronan in most locations,suggesting that during tooth development this transmembrane protein plays animportant part in hyaluronan-mediated events.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
0 (Antibodies, Monoclonal)
0 (Antigens, CD44)
Age Factors
Antibodies, Monoclonal
Antigens, CD44/*analysis/biosynthesis
Embryonic and Fetal Development
Infant, Newborn
Tooth Germ/*chemistry/metabolism
egyetemen (Magyarországon) készült közlemény
Megjelenés:Archives of Oral biology. - 46 : 10 (2001), p. 939-945. -
További szerzők:Módis László (1939-) (anatómus, kötőszövetbiológus) Tammi, Markku (kutatóorvos) Tammi, Raija (kutatóorvos)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
elektronikus elérés


001-es BibID:BIBFORM015602
035-os BibID:16317603
Első szerző:Klekner Álmos (idegsebész)
Cím:Quantitative determination of hyaluronan content in cerebral aneurysms by digitaldensitometry / Klekner A., Felszeghy S., Tammi R., Tammi M., Csécsei G., Módis L.
ISSN:0044-4251 (Linking)
Megjegyzések:OBJECT: Hyaluronan (HA) is a highly hydrated macromolecule; it is one of theessential components of the extracellular matrix (ECM) of the arteries and playsan important role in maintaining the biomechanical features of blood vessels.Although the potential contribution of HA in aneurysms of different vessels hasbeen studied intensively, no data are available about the alteration of the HAcontent in the extracellular matrix of intracranial aneurysms. The aim of thestudy was to determine the hyaluronan content in the wall of human cerebralarteries. METHODS: A biotinylated aggrecan fragment that binds specifically to HAwas used to stain samples from cerebral aneurysms (n = 11) to compare the HAcontent to non-aneurysmal arteries of patients who had intracranial aneurysm (n =11), and to histologically normal arteries of patients who had expired fromnon-vascular diseases (n = 14). Digital microscopic densitometry was used for thequantitative analysis of the hyaluronan content in these samples. RESULTS: TheCONCLUSIONS: Results suggest that an elevated hyaluronan level in theextracellular matrix may affect the cerebral arterial wall architecture. It isreasonable to suppose that the increased hyaluronan content creates aviscoelastic ECM which might improve the biomechanical resistance of the thinnedvessel wall.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
9004-61-9 (Hyaluronic Acid)
Aged, 80 and over
Cerebral Arteries/*metabolism/pathology
Circle of Willis/metabolism/pathology
Hyaluronic Acid/*metabolism
Image Processing, Computer-Assisted
Intracranial Aneurysm/*metabolism/pathology
Middle Aged
egyetemen (Magyarországon) készült közlemény
Megjelenés:Zentralblatt fur Neurochirurgie. - 66 : 4 (2005), p. 207-12. -
További szerzők:Felszeghy Szabolcs Béla (1972-) (fogorvos, anatómus, kötőszövetbiológus) Tammi, Raija (kutatóorvos) Tammi, Markku (kutatóorvos) Csécsei György (1948-2005) (idegsebész) Módis László (1939-) (anatómus, kötőszövetbiológus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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