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001-es BibID:BIBFORM006761
Első szerző:Inbal, Amir
Cím:Impaired wound healing in factor XIII deficient mice / Inbal, A., Lubetsky, A., Krapp, T., Castel, D., Shaish, A., Dickneitte, G., Modis, L., Muszbek, L., Inbal, A.
Megjegyzések:Factor XIII that stabilizes fibrin clots in the final stages of blood coagulation also participates in wound healing, as can be inferred from a delay in wound repair in some patients with inherited FXIII deficiency. In this study we evaluated the effect of FXIII on wound healing in FXIII-deficient mice. Three groups of mice (n = 10) were employed: control group, FXIII-deficient group and FXIII-deficient group treated with FXIII concentrate. Excisional wounds were left unsutured and undressed, and mice were followed for eleven days. FXIII-deficient mice exhibited impaired wound healing as has been demonstrated by 15%, 27% and 27% decrease in percentage of wound closure on day 4, 8 and 11, respectively. On day 11 complete healing was observed in control (100% closure), 73.23% in FXIII-deficient and 90.06% in FXIII deficient/FXIII-treated groups (p = 0.007 by ANOVA and p = 0.001 by t-test between control and FXIII-deficient groups). Scoring system representing maturation rate of the wounds showed that the scores for the control, FXIII-deficient and FXIII deficient/FXIII treated groups were 94.9 +/- 4.7, 61.5 +/- 14.5 and 94.5 +/- 6.4, respectively (p < 0.001 by ANOVA). Histological analysis of the lesions performed at day 11 disclosed delayed reepithelization and necrotized fissure in FXIII-deficient mice and normal healing in FXIII-deficient/FXIII-treated mice. The findings of this study confirm that in FXIII-deficient mice wound healing is delayed and the cellular and tissue defects can be corrected by treatment with FXIII, providing evidence for the essential role of FXIII in wound repair and remodeling.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Analysis of Variance
Factor XIII/genetics/physiology
Gene Deletion
Mice, Inbred CBA
Time Factors
Wound Healing
Megjelenés:Thrombosis and Haemostasis. - 94 : 2 (2005), p. 432-437. -
További szerzők:Lubetsky, Aharon Krapp, Tanya Castel, David Shaish, Aviv Dickneitte, Gerhardt Módis László (1939-) (anatómus, kötőszövetbiológus) Muszbek László (1942-) (haematológus, kutató orvos) Inbal, Aida
Internet cím:DOI
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