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001-es BibID:	BIBFORM129643
035-os BibID:	(WoS)001477331500001 (Scopus)105003599606
Első szerző:	Nemes-Tömöri Dóra (orvos)
Cím:	Malignancy in Systemic Sclerosis : a Multicenter Retrospective Study / Nemes-Tömöri Dóra, Jász Dávid Kurszán, Tari Dóra, Bói Bernadett, Ágoston-Szabó Ágnes, Szűcs Gabriella, Majai Gyöngyike Emese
Dátum:	2025
ISSN:	2227-9059
Megjegyzések:	Background/Objectives: Systemic sclerosis (SSc) is associated with high malignancy risk. With improving SSc management, tumor risk could change, therefore re-evaluating the possibility of neoplasms is necessary. Our aim was to observe malignancy prevalence and its risk factors in the Hungarian SSc population, comparing them to our previous and international results. Methods: We retrospectively collected the data of SSc patients followed by and admitted to three Hungarian clinical centers between 2018 and 2024. The collected data included the characteristics of SSc and neoplasms, autoantibody positivities, immunosuppressive treatments, pregnancy and environmental factors. Results: Out of 541 patients, 85 had malignancy and, in total, 96 tumors were registered. Skin cancer was the most common (n = 24), followed by breast (n = 14) and lung cancer (n = 14). Among skin cancers, almost one-third was melanoma. Tumors mostly appeared in two peaks: around the time of SSc diagnosis and 10 years later. The occurrence of anti-RNA Polymerase III (anti-RNAPIII) was significantly higher in cancerous patients. Tumor risk was higher with anti-RNAPIII (Odds Ratio (OR) 4.33, 95% Confidence Interval (95% CI) 1.08, 15.1) and anti-topoisomerase I (ATA) (OR 2.34, 95% CI 0.94, 5.84) positivity. Women and patients with diffuse cutaneous SSc (dcSSc) were more likely to have malignancy. Smoking (OR 1.27, 95% CI 0.53, 3.00) also raised the possibility of carcinogenesis. Cancerous patients were older (p-value = 0.003), and their mortality was worse compared to non-cancerous patients (Hazard Ratio (HR) 4.75, 95% CI 2.12, 10.62). Pregnancy did not provide a protective effect against breast cancer. Conclusions: Malignancy significantly contributes to the increased mortality in SSc. Female gender, dcSSc, anti-RNAPIII positivity, smoking and older age represent a higher risk of tumors. Dermatological cancer screening is necessary for all patients with SSc.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk systemic sclerosis scleroderma cancer malignancy skin cancer
Megjelenés:	Biomedicines. - 13 : 4 (2025), p. 1-16. -
További szerzők:	Jász Dávid Kurszán Tari Dóra Bói Bernadett Ágoston-Szabó Ágnes Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Majai Gyöngyike (1977-) (belgyógyász, immunológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM115781
035-os BibID:	(WoS)001094603500001
Első szerző:	Nemes-Tömöri Dóra (orvos)
Cím:	A rare association of neuromyelitis optica, antisynthetase, and antiphospholipid syndrome / Nemes-Tömöri Dóra, Csabalik Richárd, Nagy Edit Boglárka, Béldi Tibor, Majai Gyöngyike Emese
Dátum:	2023
ISSN:	2050-0904
Megjegyzések:	The association of neuromyelitis optica concurrently with two other autoimmune diseases is rare. Neuromyelitis optica should be taken into consideration when evaluating the symptoms of the patient as a differential diagnostic aspect.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Devic's syndrome antiphospholipid syndrome antisynthetase syndrome neuromyelitis optica
Megjelenés:	Clinical Case Reports. - 11 : 11 (2023), p. 1-4. -
További szerzők:	Csabalik Richárd (1986-) (neurológus) Nagy Edit Boglárka Béldi Tibor (1994-) (orvos) Majai Gyöngyike (1977-) (belgyógyász, immunológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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