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001-es BibID:	BIBFORM001623
Első szerző:	Sóczó Georgina
Cím:	Correlation of posaconazole minimum fungicidal concentration and time-kill test against nine Candida species / G. Sóczó, G. Kardos, P. M. McNicholas, E. Balogh, L. Gergely, I. Varga, B. Kelentey, L. Majoros
Dátum:	2007
Megjegyzések:	OBJECTIVES: We evaluated the in vitro activity of posaconazole against nine Candida species using minimum fungicidal concentration (MFC) measurements and time-kill methods. METHODS: MFCs of posaconazole were determined for 209 clinical isolates (32 Candida albicans, 30 Candida glabrata, 21 Candida tropicalis, 29 Candida krusei, 28 Candida parapsilosis sensu stricto, 50 Candida inconspicua, 13 Candida kefyr, 3 Candida lusitaniae and 3 Candida guilliermondii) and 7 ATCC Candida strains. The following strains were tested in time-kill studies: 3 strains each of C. glabrata, C. kefyr, C. guilliermondii and C. lusitaniae; 2 C. tropicalis; 4 C. albicans; 4 C. inconspicua; 9 C. krusei; 12 C. parapsilosis; and 7 ATCC strains. RESULTS: Posaconazole was fungicidal in both MFC and time-kill experiments (at 2 mg/L within 48 h in time-kill assays) against each C. krusei, C. inconspicua and C. lusitaniae strain and was fungistatic against each C. albicans, C. glabrata, C. tropicalis and C. guilliermondii strain. For the C. parapsilosis strains, posaconazole MFCs were <or=2 mg/L for 20 of the 28 isolates tested; however, in the time-kill tests, even at drug concentrations of 32-64 x MIC, posaconazole was fungistatic against all C. parapsilosis strains tested. CONCLUSIONS: MFC values were good predictors of the fungistatic or fungicidal activity of posaconazole, as determined by time-kill curves, for all tested species except C. parapsilosis. Our results highlight the fungicidal action of posaconazole against a number of clinically relevant Candida species.
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban posaconazole Candida
Megjelenés:	The Journal of Antimicrobial Chemotherapy 60 : 5 (2007), p. 1004-1009. -
További szerzők:	Kardos Gábor (1974-) (szakorvos, klinikai mikrobiológus) McNicholas, Paul M. Balogh Éva Gergely Lajos (1940-) (szakorvos, klinikai mikrobiológus) Varga István (1974-) (fogszakorvos) Kelentey Barna (1959-) (fogszakorvos) Majoros László (1966-) (szakorvos, klinikai mikrobiológus)
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001-es BibID:	BIBFORM001622
Első szerző:	Sóczó Georgina
Cím:	Posaconazole susceptibility testing against Candida species : comparison of broth microdilution and E-test methods / Sóczó G., Kardos G., McNicholas P. M., Falusi E., Gergely L., Majoros L.
Dátum:	2007
Megjegyzések:	Posaconazole (POS) is a newer triazole with activity against yeasts and moulds. POS and fluconazole were tested in vitro against 32 Candida albicans, 30 C. glabrata, 21 C. tropicalis, 29 C. krusei, 28 C. parapsilosis, 50 C. inconspicua, 13 C. kefyr and 5 C. famata isolates using CLSI broth microdilution method (BMD). We compared E-test and a modified BMD using polyethylene-glycol (PEG) as solvent to the CLSI method. BMDs and E-test were performed according to CLSI and the manufacturer's instructions respectively. Geometric means of POS MICs using BMD were 0.71, 0.22 and 0.21 microg ml(-1) against C. glabrata, C. krusei and C. inconspicua, respectively, and remained below 0.1 microg ml(-1) against all other species tested. One of two C. albicans and two of three C. glabrata isolates resistant to fluconazole showed MICs above 8 microg ml(-1) to POS. The impact of using PEG instead of DMSO had only a minor effect (agreements above 95% with the exception of C. parapsilosis). E-tests read after 24 h showed good agreement with the BMD. POS exhibited excellent in vitro activity against Hungarian Candida strains. E-test showed good correlation with the CLSI method, but to facilitate the comparability of results we believe that DMSO should be used as solvent in the BMD.
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban Candida posaconazole
Megjelenés:	Mycoses. - 50 : 3 (2007), p. 178-182. -
További szerzők:	Kardos Gábor (1974-) (szakorvos, klinikai mikrobiológus) McNicholas, Paul M. Falusi Erzsébet Gergely Lajos (1940-) (szakorvos, klinikai mikrobiológus) Majoros László (1966-) (szakorvos, klinikai mikrobiológus)
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