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001-es BibID:	BIBFORM107547
035-os BibID:	(scopus)84937718267 (wos)000358070400031
Első szerző:	Széles Lajos (molekuláris biológus)
Cím:	TLR3-Mediated CD8+ Dendritic Cell Activation Is Coupled with Establishment of a Cell-Intrinsic Antiviral State / Széles Lajos, Meissner Felix, Dunand-Sauthier Isabelle, Thelemann Christoph, Hersch Micha, Singovski Simon, Haller Sergio, Gobet Florian, Fuertes Marraco Silvia A., Mann Matthias, Garcin Dominique, Acha-Orbea Hans, Reith Walter
Dátum:	2015
ISSN:	0022-1767 1550-6606
Megjegyzések:	Because of their unique capacity to cross-present Ags to CD8+ T cells, mouse lymphoid tissue?resident CD8+ dendritic cells (DCs) and their migratory counterparts are critical for priming antiviral T cell responses. High expression of the dsRNA sensor TLR3 is a distinctive feature of these cross-presenting DC subsets. TLR3 engagement in CD8+ DCs promotes cross-presentation and the acquisition of effector functions required for driving antiviral T cell responses. In this study, we performed a comprehensive analysis of the TLR3-induced antiviral program and cell-autonomous immunity in CD8+ DC lines and primary CD8+ DCs. We found that TLR3-ligand polyinosinic-polycytidylic acid and human rhinovirus infection induced a potent antiviral protection against Sendai and vesicular stomatitis virus in a TLR3 and type I IFN receptor?dependent manner. Polyinosinic-polycytidylic acid?induced antiviral genes were identified by mass spectrometry?based proteomics and transcriptomics in the CD8+ DC line. Nanostring nCounter experiments confirmed that these antiviral genes were induced by TLR3 engagement in primary CD8+ DCs, and indicated that many are secondary TLR3-response genes requiring autocrine IFN-? stimulation. TLR3-activation thus establishes a type I IFN?dependent antiviral program in a DC subtype playing crucial roles in priming adaptive antiviral immune responses. This mechanism is likely to shield the priming of antiviral responses against inhibition or abrogation by the viral infection. It could be particularly relevant for viruses detected mainly by TLR3, which may not trigger type I IFN production by DCs that lack TLR3, such as plasmacytoid DCs or CD8? DCs.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk antivirális immunitás interferon TLR3
Megjelenés:	Journal Of Immunology. - 195 : 3 (2015), p. 1025-1033. -
További szerzők:	Meissner, Felix Dunand-Sauthier, Isabelle Thelemann, Christoph Hersch, Micha Singovski, Simon Haller, Sergio Gobet, Florian Fuertes Marraco, Silvia A. Mann, Matthias Garcin, Dominique Acha-Orbea, Hans Reith, Walter
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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