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001-es BibID:	BIBFORM038953
Első szerző:	Márton Ildikó (fogszakorvos)
Cím:	Differential in situ distribution of interleukin-8, monocyte chemoattractant protein-1 and Rantes in human chronic periapical granuloma / I. J. Márton, A. Rot, E. Schwarzinger, S. Szakáll, T. Radics, I. Vályi-Nagy, C. Kiss
Dátum:	2000
ISSN:	0902-0055
Megjegyzések:	In situ distribution of three prototype chemokines interleukin (IL)-8, monocyte chemoattractant protein (MCP)-1 and Rantes was determined in chronic human periapical granulomas by immunohistochemistry using monoclonal antibodies. IL-8 was found primarily in the cytoplasm of the Malassez epithelial cells. MCP-1 immunoreactivity was confined to the endothelial cells that lined small venules. Each of the three investigated chemokines, including Rantes, exhibited a characteristic binding pattern to the extracellular matrix of the lesion. The observed chemokines may play a role in establishing the cellular composition of chronic apical periodontitis, thus augmenting the intensity of local inflammation and tissue damage.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	Oral Microbiology And Immunology. - 15 : 1 (2000), p. 63-65. -
További szerzők:	Rot Antal Schwarzinger, E. Szakáll Szabolcs Radics Tünde (1963-) (egyetemi adjunktus, fogszakorvos) Vályi-Nagy István Kiss Csongor (1956-) (hematológus, onkológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat Szerző által megadott URL DOI
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001-es BibID:	BIBFORM024256
Első szerző:	Márton Ildikó (fogszakorvos)
Cím:	Distribution of interleukin-2 receptor alpha-chain and cells expressing major histocompatibility complex class II antigen in chronic human periapical lesions / I. J. Márton, B. Dezső, T. Radics, C. Kiss
Dátum:	1998
Megjegyzések:	In situ distribution of CD2+ T-lymphocytes, CD4+ and CD8+ T-cell subsets, CD14+ macrophages, interleukin-2 receptor alpha-chain (IL-2R alpha) and class II major histocompatibility complex antigen (major histocompatibility complex class II, HLA-DR) expressing cells were determined in 14 chronic human periapical granulomas by immunohistochemical method using monoclonal antibodies. CD2+ lymphocytes were rather evenly distributed within the classical granulation tissue and comprised 55% of the mononuclear cells. Macrophages were distributed all over the periapical area, but their proportion was much less than that of T lymphocytes. Both small, lymphocyte-like mononuclear cells and larger mononuclear cells resembling macrophages displayed mild to strong circumferential staining with the anti-HLA-DR antibody. The majority of lymphocytes expressed IL-2R alpha indicating the activated state of T cells within the lesion.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Oral Microbiology Immunology. - 13 : 4 (1998), p. 259-262. -
További szerzők:	Dezső Balázs (1951-) (pathológus) Radics Tünde (1963-) (egyetemi adjunktus, fogszakorvos) Kiss Csongor (1956-) (hematológus, onkológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat Szerző által megadott URL DOI
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001-es BibID:	BIBFORM013305
Első szerző:	Radics Tünde (egyetemi adjunktus, fogszakorvos)
Cím:	Interleukin-6 and granulocytemacrophage colony-stimulating factor in apical periodontitis : correlation with clinical and histologic findings of the involved teeth / T. Radics, C. Kiss, I. Tar, I. J. Márton
Dátum:	2003
ISSN:	0902-0055
Megjegyzések:	Apical periodontitis is characterized by the presence of immunocompetent cells producing a wide variety of inflammatory mediators. Releasing cytokines with long-range action, such as interleukin-6 (IL-6) and granulocyte-macrophage colony-stimulating factor (GM-CSF), apical periodontitis may induce changes in remote organs of the host. This study quantified the levels of IL-6 and GM-CSF in symptomatic and asymptomatic human periradicular lesions. Lesions were also characterized by size and histologic findings. Tissue samples were homogenized and supernatants were assayed using an enzyme-linked immunosorbent assay (ELISA). Correlations between cytokine levels and characteristic features (as single variables) of the lesions were analysed. There was a trend for higher levels of IL-6 and GM-CSF in symptomatic than in asymptomatic lesions, but the difference was not significant. Levels also tended to be higher in large than in small lesions, in polymorphonuclear (PMN) cell-rich than in PMN cell-poor samples, and in epithelialized than in non-epithelialized lesions. Significantly higher levels of IL-6 (778.1 +/- 220.5 pg/microg) and GM-CSF (363.3 +/- 98.4 pg/microg) were found in samples coincidentally possessing symptomatic and epithelialized features than in asymptomatic, small, PMN cell-poor, non-epithelialized lesions (IL-6: 45.2 +/- 13.1 pg/microg and GM-CSF: 135.1 +/- 26.4 pg/microg). These results suggest that symptomatic lesions containing epithelial cells represent an immunologically active stage of apical periodontitis, whereas asymptomatic, small, PMN cell-poor, non-epithelialized lesions represent healing apical lesions.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban cytokines granulocytemacrophage colony-stimulating factor interleukin-6 periodontitis
Megjelenés:	Oral Microbiology And Immunology. - 18 : 1 (2003), p. 9-13. -
További szerzők:	Kiss Csongor (1956-) (hematológus, onkológus) Tar Ildikó (1967-) (fogszakorvos) Márton Ildikó (1954-) (fogszakorvos)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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