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001-es BibID:	BIBFORM067028
Első szerző:	Herédi Emese (bőrgyógyász)
Cím:	Subclinical cardiovascular disease and it's improvement after long-term TNF-[alfa] inhibitor therapy in severe psoriatic patients / Herédi E., Végh J., Pogácsás L., Gáspár K., Varga J., Kincse G., Zeher M., Szegedi A., Gaál J.
Dátum:	2016
ISSN:	0926-9959
Megjegyzések:	BACKGROUND:There are conflicting data on the occurrence of subclinical myocardial dysfunction in psoriatic patients and on the impact of long-term tumour necrosis factor-alpha (TNF-[alfa]) inhibitor therapy on cardiac function.OBJECTIVE:In this study, we explored whether there are any signs of subclinical cardiovascular disease (echocardiographic abnormalities) in severe psoriatic patients without clinically overt heart disease. As a second objective, the influence of long-term treatment with TNF-[alfa] inhibitors on the ventricular functions of psoriatic patients was also investigated.METHODS:Clinical and echocardiographic data from 44 psoriatic patients and 45 age- and sex-matched controls were processed. As a first step, the echocardiographic parameters of psoriatic patients obtained before anti-TNF-[alfa] treatment were compared with controls. As a second step, to detect the effect of long-term anti-TNF-[alfa] treatment on echocardiographic parameters, data of patients before and after therapy were analysed.RESULTS:The right ventricular Tei index was higher (P < 0.001), whereas the tricuspid annular plane systolic excursion (TAPSE) and right ventricular free wall peak systolic velocity were lower (P < 0.001 and P < 0.0001, respectively) in the psoriatic patients than in the controls. Following treatment with TNF-[alfa] inhibitors, TAPSE and right ventricular free wall peak systolic velocity significantly improved (P < 0.0001 for both parameters). The Tei index of both ventricles improved during biological therapy; however, this change did not reach statistical significance.CONCLUSION:Patients with severe psoriasis exhibit signs of subclinical cardiovascular disease compared to control, and prolonged anti-TNF-[alfa] therapy has a potentially beneficial effect on these signs.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Journal Of The European Academy Of Dermatology And Venereology. - 30 : 9 (2016), p. 1531-1536. -
További szerzők:	Végh Judit (1968-) (belgyógyász, kardiológus) Pogácsás Lilla Gáspár Krisztián (1974-) (bőrgyógyász) Varga József (1955-) (fizikus) Kincse Gyöngyvér (1970-) (orvos) Zeher Margit (1957-2018) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Szegedi Andrea (1964-) (bőrgyógyász) Gaál János (1965-) (reumatológus, belgyógyász)
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001-es BibID:	BIBFORM059610
Első szerző:	Kincse Gyöngyvér (orvos)
Cím:	Vitamin D3 levels and bone mineral density in patients with psoriasis and/or psoriatic arthritis / Gyöngyvér Kincse, Pál Harjit Bhattoa, Emese Herédi, József Varga, Andrea Szegedi, Judit Kéri, János Gaál
Dátum:	2015
ISSN:	0385-2407
Megjegyzések:	Limited data are available on the vitamin D3 status and bone mineral density (BMD) of patients with psoriasis orwith psoriatic arthritis. Our study intended to explore possible correlations between vitamin D status and BMD, aswell as among these parameters and the features of the underlying disorder. Seventy-two patients with psoriasis/or psoriatic arthritis (female : male ratio, 40:32; mean age, 58.5 ? 11.6 years; mean duration of follow up,142.7 ? 147.7 months) participated in the study. We evaluated the characteristic clinical features of the underlyingdisease, performed bone densitometry of the lumbar spine and the hip region, measured the serum vitamin 25(OH)D3 levels of the patients, and undertook the statistical analysis of the relationships between the clinical andthe laboratory parameters. The proportion of patients with a low BMD value did not exceed that seen in the generalpopulation. We found an inverse correlation between the serum level of vitamin 25(OH)D3 and body massindex, as well as between the former and the severity of skin involvement. Furthermore, the activity of psoriaticarthritis was significantly higher in patients with inadequate vitamin D3 status. In patients with psoriatic arthritis,BMD significantly exceeded the values measured in patients suffering from psoriatic skin lesions only. Our findingssuggest the importance of evaluating the vitamin D3 status and screening for comorbid conditions in patientswith psoriasis or psoriatic arthritis. This appears justified, in particular, due to the possible role of hypovitaminosisD3 in provoking the development of skin lesions and joint symptoms.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk bone mineral density D vitamin level disease activity Psoriasis
Megjelenés:	Journal Of Dermatology. - 42 : 7 (2015), p. 679-684. -
További szerzők:	Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Herédi Emese (1979-) (bőrgyógyász) Varga József (1955-) (fizikus) Szegedi Andrea (1964-) (bőrgyógyász) Kéri Judit Gaál János (1965-) (reumatológus, belgyógyász)
Pályázati támogatás:	OTKA-K108421 OTKA TÁMOP-4.2.2.A- 11/1/KONV-2012-0023 TÁMOP
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