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001-es BibID:	BIBFORM129432
035-os BibID:	(Scopus)105003250199 (WoS)001464008900003
Első szerző:	Muszka Zsuzsa (molekuláris biológus)
Cím:	Life-threatening risk factors contribute to the development of diseases with the highest mortality through the induction of regulated necrotic cell death / Zsuzsa Muszka , Viktória Jenei, Rebeka Mácsik, Evgeniya Mezhonova, Silina Diyab, Réka Csősz, Attila Bácsi, Anett Mázló, Gábor Koncz
Dátum:	2025
ISSN:	2041-4889
Megjegyzések:	Chronic diseases affecting the cardiovascular system, diabetes mellitus, neurodegenerative diseases, and various other organspecific conditions, involve different underlying pathological processes. However, they share common risk factors that contribute to the development and progression of these diseases, including air pollution, hypertension, obesity, high cholesterol levels, smoking and alcoholism. In this review, we aim to explore the connection between four types of diseases with different etiologies and various risk factors. We highlight that the presence of risk factors induces regulated necrotic cell death, leading to the release of damage-associated molecular patterns (DAMPs), ultimately resulting in sterile inflammation. Therefore, DAMP-mediated inflammation may be the link explaining how risk factors can lead to the development and maintenance of chronic diseases. To explore these processes, we summarize the main cell death pathways activated by the most common life-threatening risk factors, the types of released DAMPs and how these events are associated with the pathophysiology of diseases with the highest mortality.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Cell Death & Disease. - 16 : 1 (2025), p. 1-19. -
További szerzők:	Jenei Viktória (1997-) (biológus) Mácsik Rebeka Mezhonova, Evgeniya Diyab, Silina Csősz Réka Bácsi Attila (1967-) (immunológus) Türk-Mázló Anett (1989-) (molekuláris biológus) Koncz Gábor (1970-) (biológus, immunológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM101734
035-os BibID:	(WoS)000789850400001 (Scopus)85129238146
Első szerző:	Türk-Mázló Anett (molekuláris biológus)
Cím:	Types of necroinflammation, the effect of cell death modalities on sterile inflammation / Anett Mázló, Viktória Jenei, Sára Burai, Tamás Molnár, Attila Bácsi, Gábor Koncz
Dátum:	2022
Megjegyzések:	Distinct types of immune responses are activated by infections, which cause the development of type I, II, or III inflammation, regulated by Th1, Th2, Th17 helper T cells and ILC1, ILC2 and ILC3 cells, respectively. While the classification of immune responses to different groups of pathogens is widely accepted, subtypes of the immune response elicited by sterile inflammation have not yet been detailed. Necroinflammation is associated with the release of damage-associated molecular patterns (DAMP) from dying cells. In this review, we present that the distinct molecular mechanisms activated during apoptosis, necroptosis, pyroptosis, and ferroptosis lead to the release of different patterns of DAMPs and their suppressors, SAMPs. We summarize the currently available data on how regulated cell death pathways and released DAMPs and SAMPs direct the differentiation of T helper and ILC cells. Understanding the subtypes of necroinflammation can be crucial in developing strategies for the treatment of sterile inflammatory diseases caused by cell death processes.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Inflammasome Necroptosis
Megjelenés:	Cell Death and Disease. - 13 : 5 (2022), p. 1-12. -
További szerzők:	Jenei Viktória (1997-) (biológus) Burai Sára (1998-) (immunológus) Molnár Tamás (1989-) (molekuláris biológus) Bácsi Attila (1967-) (immunológus) Koncz Gábor (1970-) (biológus, immunológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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