CCL

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1.

001-es BibID:BIBFORM047649
Első szerző:Bácsi Attila (immunológus)
Cím:Colostrinin decreases spontaneous and induced mutation frequencies at the hprt locus in Chinese hamster V79 cells / Attila Bacsi, Leopoldo Aguilera-Aguirre, Peter German, Marian L. Kruzel, Istvan Boldogh
Dátum:2006
Megjegyzések:ColostrininTM (CLN), a uniform mixture of lowmolecular weight, proline-rich polypeptides, induces neurite outgrowth of pheochromocytoma cells, extends the lifespan of diploid fibroblast cells, inhibits beta amyloid-induced apoptosis and resulted in improved cognitive function when administered to Alzheimer's patients. Here we investigated CLN's antimutagenic activity in cells stressed oxidatively or exposed to chemical or physical agents. Our data show that CLN did not alter cell cycle kinetics and cloning efficiency, while it inhibited the development of spontaneous mutations at the coding region of the hypoxanthine phosphoribosyl-transferase (hprt) gene in Chinese hamster V79 cells. In a dosedependent manner, CLN lowered reactive oxygen species (ROS)-induced frequency of cells resistant to 6-thioguanine (6-TG) to nearly background level. Likewise, CLN decreased the frequency of methyl methanesulfonate- or mitomycin C-induced mutations in V79 cells. Notably, CLN (at 100, 250, and 500 ng per ml concentrations) decreased UVAinduced mutation frequency, while only the highest dose of CLN also decreased significantly the number of UVB-induced 6-TG-resistant mutant cells. Similar results were obtained using cell cultures of human origin. Overall, our data show that CLN significantly lowers the mutation frequency that develops spontaneously or is induced by ROS, chemical and physical agents. CLN itself has no mutagenic activity. Therefore, CLN may be used in human therapies systemically and/or locally for the prevention of diseases associated with sequence alterations in genomic and mitochondrial DNA.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
colostrinin
mutation frequency
oxidative stress
genotoxic chemical and physical agents
Megjelenés:Journal of Experimental Therapeutics and Oncology 5 : 4 (2006), p. 249-259. -
További szerzők:Aguilera-Aguirre, Leopoldo Germán Péter (gyermekgyógyász) Kruzel, Marian L. Boldogh István
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2.

001-es BibID:BIBFORM055868
Első szerző:Boldogh István
Cím:Colostrinin (TM) increases the lifespan and neurological performance of mice / Boldogh I., Bácsi A., Agulera-Aguirre L., Germán P., Kruzel M.
Dátum:2008
Tárgyszavak:Természettudományok Biológiai tudományok előadáskivonat
Megjelenés:New Trends in Alzheimer and Parkinson Related Disorders : ADPD 2007 / eds. Hanin I., Windisch M., Poewe W., Fisher A. - [1] p. -
További szerzők:Bácsi Attila (1967-) (immunológus) Aguilera-Aguirre, Leopoldo Germán Péter (gyermekgyógyász) Kruzel, Marian L.
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3.

001-es BibID:BIBFORM055875
Első szerző:Boldogh István
Cím:Role of 8-oxoG in Eliciting an Inflammatory Response / Boldogh István, Aguilera-Aguirre Leopoldo, Bácsi Attila, Germán Péter, Hajas György, Sur Sanjiv, Hazra Tapas K., Mitra Sankar
Dátum:2010
Tárgyszavak:Természettudományok Biológiai tudományok idézhető absztrakt
Megjelenés:Environmental And Molecular Mutagenesis. - 51 (2010), p. 697. -
További szerzők:Aguilera-Aguirre, Leopoldo Bácsi Attila (1967-) (immunológus) Germán Péter (gyermekgyógyász) Hajas György (1970-) (biológus) Sur, Sanjiv Hazra, Tapas K. Mitra, Sankar
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4.

001-es BibID:BIBFORM065562
Első szerző:Germán Péter (gyermekgyógyász)
Cím:8-Oxoguanine DNA glycosylase1-driven DNA repair : a paradoxical role in lung aging / Peter German, David Saenz, Peter Szaniszlo, Leopoldo Aguilera-Aguirre, Lang Pan, Muralidhar L. Hegde, Attila Bacsi, Gyorgy Hajas, Zsolt Radak, Xueqing Ba, Sankar Mitra, John Papaconstantinou, Istvan Boldogh
Dátum:2017
ISSN:0047-6374
Megjegyzések:Age-associated changes in lung structure and function are some of the most important predictors of overall health, cognitive activities and longevity. Common to all aging cells is an increase in oxidatively modified DNA bases, primarily 8-oxo-7,8-dihydroguanine (8-oxoG). It is repaired via DNA base excision repair pathway driven by 8-oxoguanine DNA glycosylase-1 (OGG1-BER), whose role in aging has been the focus of many studies. This study hypothesizes that signaling and consequent gene expression during cellular response to OGG1-BER "wires" senescence/aging processes. To test OGG1-BER was mimicked by repeatedly exposing diploid lung fibroblasts cells and airways of mice to 8-oxoG base. Results showed that repeated exposures led to G1 cell cycle arrest and pre-matured senescence of cultured cells in which over 1000 genes were differentially expressed -86% of them been identical to those in naturally senesced cells. Gene ontology analysis of gene expression displayed biological processes driven by small GTPases, phosphoinositide 3-kinase and mitogen activated kinase cascades both in cultured cells and lungs. These results together, points to a new paradigm about the role of DNA damage and repair by OGG1 in aging and age-associated disease processes.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
OGG1
8-oxoguanine
Senescence
Aging
Megjelenés:Mechanisms Of Ageing And Development 161 : Pt A (2017), p. 51-65. -
További szerzők:Saenz, David N. Szaniszló Péter Aguilera-Aguirre, Leopoldo Pan, Lang Hegde, Muralidhar L. Bácsi Attila (1967-) (immunológus) Hajas György (1970-) (biológus) Radák Zsolt Ba, Xueqing Mitra, Sankar Papaconstantinou, John Boldogh István
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DOI
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5.

001-es BibID:BIBFORM047640
Első szerző:Germán Péter (gyermekgyógyász)
Cím:Activation of cellular signaling by 8-oxoguanine DNA glycosylase-1-initiated DNA base excision repair / Peter German, Peter Szaniszlo, Gyorgy Hajas, Zsolt Radak, Attila Bacsi, Tapas K. Hazra, Muralidhar L. Hegde, Xueqing Ba, Istvan Boldogh
Dátum:2013
ISSN:1568-7864
Megjegyzések:Accumulation of 8-oxo-7,8-dihydroguanine (8-oxoG) in the DNA results in genetic instability and mutagenesis, and is believed to contribute to carcinogenesis, aging processes and various aging-related diseases. 8-OxoG is removed from the DNA via DNA base excision repair (BER), initiated by 8-oxoguanine DNA glycosylase-1 (OGG1). Our recent studies have shown that OGG1 binds its repair product 8-oxoG base with high affinity at a site independent from its DNA lesion-recognizing catalytic site and the OGG1?8-oxoG complex physically interacts with canonical Ras family members. Furthermore, exogenously added 8-oxoG base enters the cells and activates Ras GTPases; however, a link has not yet been established between cell signaling and DNA BER, which is the endogenous source of the 8-oxoG base. In this study, we utilized KG-1 cells expressing a temperature-sensitive mutant OGG1, siRNA ablation of gene expression, and a variety of molecular biological assays to define a link between OGG1-BER and cellular signaling. The results show that due to activation of OGG1-BER, 8-oxoG base is released from the genome in sufficient quantities for activation of Ras GTPase and resulting in phosphorylation of the downstream Ras targets Raf1, MEK1,2 and ERK1,2. These results demonstrate a previously unrecognized mechanism for cellular responses to OGG1-initiated DNA BER.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Ogg1
Base excision repair
Cell signaling
Megjelenés:Dna Repair. - 12 : 10 (2013), p. 856-863. -
További szerzők:Szaniszló Péter Hajas György (1970-) (biológus) Radák Zsolt Bácsi Attila (1967-) (immunológus) Hazra, Tapas K. Hegde, Muralidhar L. Ba, Xueqing Boldogh István
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6.

001-es BibID:BIBFORM030561
Első szerző:Hajas György (biológus)
Cím:Biochemical identification of a hydroperoxide derivative of the free 8-oxo-7,8-dihydroguanine base / Gyorgy Hajas, Attila Bacsi, Leopoldo Aguilerra-Aguirre, Peter German, Zsolt Radak, Sanjiv Sur, Tapas K. Hazra, Istvan Boldogh
Dátum:2012
ISSN:0891-5849
Megjegyzések:-Oxo-7,8-dihydroguanine is one the most abundant base lesions in pro- and eukaryotic DNA. In mammalian cells, it is excised by the 8-oxoguanine DNA glycosylase (OGG1) during DNA base-excision repair, and the generated free 8-oxoG base is one of the DNA-derived biomarkers of oxidative stress in biological samples. The modification of 8-oxoG in the context of nucleoside and DNA has been the subject of many studies; however, the oxidative transformation of the free 8-oxoG base has not been described. By using biochemical and cell biological assays, we show that in the presence of molecular oxygen, the free 8-oxoG base transforms to a highly reactive hydroperoxide (8-oxoG*). Specifically, 8-oxoG* oxidizes Amplex red to resorufin, H(2)DCF to DCF, Fe(2+) to Fe(3+), and GSH to GSSG. This property of 8-oxoG* was diminished by treatment with catalase and glutathione peroxidase, but not superoxide dismutase. 8-OxoG* formation was prevented by reducing agents or nitrogen atmosphere. Its addition to CM-H(2)DCF-DA-loaded cells rapidly increased intracellular DCF fluorescence. There were no such properties observed for 8-oxodeoxyguanosine, 2,6-diamino-4-hydroxy-5-formamidopyrimidine, 2'-deoxyguanosine, guanine, adenine, guanosine, and 8-hydroxyadenine. These data imply that a free 8-oxoG base is more susceptible to oxidation than is its nucleoside form and, consequently, it stands as unique among intact and oxidatively modified purines.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Molekuláris Medicina
Free 8-oxoguanine base
Oxidative stress
Free radicals
külföldön készült közlemény
Megjelenés:Free Radical Biology And Medicine 52 : 4 (2012), p. 749-756. -
További szerzők:Bácsi Attila (1967-) (immunológus) Aguilera-Aguirre, Leopoldo Germán Péter (gyermekgyógyász) Radák Zsolt Sur, Sanjiv Hazra, Tapas K. Boldogh István
Pályázati támogatás:TÁMOP-4.2.1/B-09/1/KONV-2010-0007
TÁMOP
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