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001-es BibID:	BIBFORM035804
Első szerző:	Bánhegyi Dénes
Cím:	Significant decrease of the enhancement/neutralization index in HIV patients during highly active antiretroviral therapy (HAART) / Bánhegyi Dénes, Bácsi Attila, Tóth Ferenc D., Prohászka Zoltán, Horváth Anna, Beck Zoltán, Kónya József, Füst George
Dátum:	2003
ISSN:	0165-2478
Megjegyzések:	Authors studied the effect of highly active antiretroviral therapy (HAART) on balance of the antibodies that enhance or neutralize growth of HIV-1(IIIB) strain in MT-4 cells in the presence or absence of human complement. Sequential serum samples were collected from 28 patients in advanced stage of HIV disease before and during HAART. The balance of the enhancing and neutralizing antibodies was expressed by an index value (E/N I). Samples with an E/N I of <0.5 (twofold decrease in virus production) were considered as neutralizing, whereas samples with an E/N I>2.0 (twofold increase in virus production) were considered as enhancing. At the beginning of HAART serum samples from eight patients enhanced, and samples from only two patients neutralized the virus in the presence of complement, median (25th-75th percentile) value of E/N I was 1.32 (0.79-2.29). E/N I significantly (P<0.0001) dropped to 0.37 (0.19-0.57) during the follow-up period of 18.5 (10.5-23.5) months under HAART. Similar changes were detected when serum samples were tested with no complement added. The E/N I values were also markedly decreased when cultures inoculated with mixtures of HIV and purified IgG prepared from serum pools taken before and during HAART, respectively, were compared. In the last samples of 20/28 patients, neutralization was measured even in the presence of complement while enhancement was found with none of these samples. These findings suggest that HAART results in disappearance of enhancing antibodies and switches the E/N I toward neutralization.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Immunology Letters. - 89 : 1 (2003), p. 25-30. -
További szerzők:	Bácsi Attila (1967-) (immunológus) Tóth Ferenc, D. (1940-2004) (mikrobiológus, élettanász) Prohászka Zoltán Horváth Anna Beck Zoltán (1970-) (molekuláris biológus, mikrobiológus) Kónya József (1964-) (szakorvos, klinikai mikrobiológus) Füst György (Budapest)
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001-es BibID:	BIBFORM047642
035-os BibID:	PMID:11563675
Első szerző:	Horváth Anna
Cím:	High level of anticholesterol antibodies (ACHA) in HIV patients. Normalization of serum ACHA concentration after introduction of HAART / Anna Horváth, Dénes Bánhegyi, Adrien Bíró, Eszter Ujhelyi, Amarilla Veres, Laura Horváth, Zoltán Prohászka, Attila Bácsi, Vera Tarján, László Romics, István Horváth, Ferenc D. Tóth, George Füst, István Karádi
Dátum:	2001
ISSN:	0171-2985
Megjegyzések:	Anticholesterol antibodies (ACHA) are natural antibodies against the 3~-OH group of cholesterol.Since lipid disorders are common in HIV infection and HAART may further enhance dislipidaemia,we determined by using an ELISA method serum ACHA concentrations in HIV patients and healthyHIV-seronegative controls.ACHA levels were almost 4 times higher in the sera of 46 patients than in 110 controls. No differencein the specificity of ACHA was found between HIV-seropositive and HIV-seronegative sera.Binding ofACHA to cholesterol-coated plates from a HIV-seropositive serum was dose-dependentlyinhibited by preincubation with HIV-l BA-L preparation. Serum concentration of ACHA was significantlyhigher in the patients with low serum cholesterol levels than in those with normal cholesterol levelseHAART induced a marked drop ofACHA concentration. We found a significant negative correlationbetween the length of HAART and the ACHA levels. By contrast, HAART did not significantlyinfluence total IgG concentration and titers of antibodies against 60 kD heat shock protein.Our findings indicate that high levels ofACHA in HIV-infection may contribute to the developmentof hypocholesterolaemia frequently observed in this disease.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Immunobiology. - 203 : 5 (2001), p. 756-768. -
További szerzők:	Bánhegyi Dénes Bíró Adrienn Ujhelyi Eszter Veres Amarilla Horváth Laura Prohászka Zoltán Bácsi Attila (1967-) (immunológus) Tarján Vera Romics László Horváth István Tóth Ferenc, D. (1940-2004) (mikrobiológus, élettanász) Füst György (Budapest) Karádi István (1952-) (belgyógyász, kardiológus)
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