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001-es BibID:	BIBFORM047644
Első szerző:	Boldogh István
Cím:	ROS generated by pollen NADPH oxidase provide a signal that augments antigen-induced allergic airway inflammation / Istvan Boldogh, Attila Bacsi, Barun K. Choudhury, Nilesh Dharajiya, Rafeul Alam, Tapas K. Hazra, Sankar Mitra, Randall M. Goldblum, Sanjiv Sur
Dátum:	2005
ISSN:	0021-9738
Megjegyzések:	Pollen exposure induces allergic airway inflammation in sensitized subjects. The role of antigenic pollen proteinsin the induction of allergic airway inflammation is well characterized, but the contribution of otherconstituents in pollen grains to this process is unknown. Here we show that pollen grains and their extractscontain intrinsic NADPH oxidases. The pollen NADPH oxidases rapidly increased the levels of ROS in lungepithelium as well as the amount of oxidized glutathione (GSSG) and 4-hydroxynonenal (4-HNE) in airwayliningfluid. These oxidases, as well as products of oxidative stress (such as GSSG and 4-HNE) generated bythese enzymes, induced neutrophil recruitment to the airways independent of the adaptive immune response.Removal of pollen NADPH oxidase activity from the challenge material reduced antigen-induced allergic airwayinflammation, the number of mucin-containing cells in airway epithelium, and antigen-specific IgE levelsin sensitized mice. Furthermore, challenge with Amb a 1, the major antigen in ragweed pollen extract that doesnot possess NADPH oxidase activity, induced low-grade allergic airway inflammation. Addition of GSSG or4-HNE to Amb a 1 challenge material boosted allergic airway inflammation. We propose that oxidative stressgenerated by pollen NADPH oxidases (signal 1) augments allergic airway inflammation induced by pollenantigen (signal 2).
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban DNA double strand breaks
Megjelenés:	Journal of Clinical Investigation. - 115 : 8 (2005), p. 2169-2179. -
További szerzők:	Bácsi Attila (1967-) (immunológus) Choudhury, Barun K. Dharajiya, Nilesh G. Alam, Rafeul Hazra, Tapas K. Mitra, Sankar Goldblum, Randall M. Sur, Sanjiv
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