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001-es BibID:	BIBFORM113591
035-os BibID:	(scopus)85166243364 (cikkazonosító)105028
Első szerző:	Pan, Lang
Cím:	Nei-like DNA glycosylase 2 (NEIL2) selectively antagonizes interferon-β expression upon respiratory syncytial virus infection / Pan Lang, Xue Yaoyao, Wang Ke, Zheng Xu, Islam Azharul, Tapryal Nisha, Chakraborty Anirban, Bacsi Attila, Ba Xueqing, Hazra Tapas K., Boldogh Istvan
Dátum:	2023
ISSN:	0021-9258 1083-351X
Megjegyzések:	As part of the antiviral response, cells activate the expressions of type I interferons (IFNs) and proinflammatory mediators to control viral spreading. Viral infections can impact DNA integrity, however, how DNA damage-repair coordinates antiviral response remains elusive. Here we report Nei-like DNA glycosylase 2 (NEIL2), a transcription-coupled DNA repair protein, actively recognizes the oxidative DNA substrates induced by respiratory syncytial virus (RSV) infection to set the threshold of IFN-? expression. Our results show that NEIL2 antagonizes nuclear factor ?B (NF-?B) acting on the IFN-? promoter early after infection, thus limiting gene expression amplified by type I IFNs. Mice lacking Neil2 are far more susceptible to RSV-induced illness with exuberant expression of proinflammatory genes and tissue damage, and the administration of NEIL2 protein into the airway corrected these defects. These results suggest a safeguarding function of NEIL2 in controlling IFN-? levels against RSV infection. Due to the short and long term side effects of type I IFNs applied in antiviral therapy, NEIL2 may provide an alternative not only for ensuring genome fidelity, but also for controlling immune responses.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk oxidative stress DNA damage NF-kB transcription regulation inflammation innate immunity antiviral response
Megjelenés:	Journal Of Biological Chemistry. - 299 : 8 (2023), p. 1-15. -
További szerzők:	Xue, Yaoyao Wang, Ke Zheng, Xu Islam, Azharul Tapryal, Nisha Chakraborty, Anirban Bácsi Attila (1967-) (immunológus) Ba, Xueqing Hazra, Tapas K. Boldogh István
Pályázati támogatás:	TKP2021-EGA-19 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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