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1.

001-es BibID:BIBFORM029746
Első szerző:Groothuis, Dennis
Cím:Hyperosmotic Blood-Brain Barrier Disruption : reply / Dennis Groothuis, Gregory Lapin, Peter Warnke, Peter Molnar
Dátum:1990
ISSN:0022-3085
Tárgyszavak:Orvostudományok Klinikai orvostudományok levél
Megjelenés:Journal Of Neurosurgery. - 73 : 5 (1990), p. 806-807. -
További szerzők:Lapin, Gregory D. Warnke, Peter C. Molnár Péter Pál (1951-) (pathológus)
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2.

001-es BibID:BIBFORM029745
Első szerző:Groothuis, Dennis
Cím:Blood-brain barrier disruption in brain-tumor therapy / Dennis R. Groothuis, Peter C. Warnke, Peter Molnar, Gregory D. Lapin, Michael A. Mikhael.
Dátum:1990
Tárgyszavak:Orvostudományok Klinikai orvostudományok levél
Megjelenés:Journal of Neurosurgery. - 73 : 3 (1990), p. 476-477. -
További szerzők:Warnke, Peter C. Molnár Péter Pál (1951-) (pathológus) Lapin, Gregory D. Mikhael, Michael A.
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3.

001-es BibID:BIBFORM029733
Első szerző:Groothuis, Dennis
Cím:Effect of hyperosmotic blood-brain barrier disruption on transcapillary transport in canine brain tumors / Groothuis Dennis R., Warnke Peter C., Molnar Peter, Lapin Gregory D., Mikhael Michael A.
Dátum:1990
ISSN:0022-3085
Megjegyzések:Whether hyperosmotic blood-brain barrier (BBB) disruption is a technique that can be used to increase permeability of brain-tumor capillaries and thereby transiently increase drug delivery to the brain tumor is controversial. Nine virally induced brain tumors were studied in seven dogs, before and after hyperosmotic BBB disruption with 1.4 osmolar mannitol. Each dog was studied with computerized tomography (CT) after administration of the water-soluble tracer meglumine iothalamate. Each study lasted 30 minutes. A baseline CT scan and 35 to 40 additional CT scans were obtained to provide a time-related measurement of the amount of meglumine iothalamate in tissue (Am(t], and 30 plasma samples were collected to provide the time-related measurement of meglumine iothalamate in plasma (Cp(t]. The data were analyzed by three different methods: 1) a two-compartment model and nonlinear curve fitting were used to calculate K1 (blood-to-tissue or influx constant), k2 (tissue-to-blood or efflux constant), and Vp (plasma vascular space); 2) K1 values were calculated with a two-compartment model, assuming no efflux, at the time point for each CT scan; and 3) a "tissue advantage ratio" was calculated that expressed the ratio of tissue uptake of meglumine iothalamate at each time point, comparing values before and after BBB disruption. Regardless of which method of data analysis was used, there was a marked and significant increase in transcapillary transport of meglumine iothalamate to tumor-free brain regions, while there was only a small, transient, and insignificant increase to the brain tumors. Although there were often marked increases in delivery to cortex in the same hemisphere as the tumors, there was no significant increase to brain immediately surrounding the tumors, perhaps due to altered circulatory dynamics in this region. These data raise serious questions as to the wisdom of using this technique to increase drug delivery to brain tumors in patients and strongly support the continued study of this technique in experimental brain tumors before it is used in patients.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Neurosurgery. - 72 : 3 (1990), p. 441-449. -
További szerzők:Warnke, Peter C. Molnár Péter Pál (1951-) (pathológus) Lapin, Gregory D. Mikhael, Michael A.
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4.

001-es BibID:BIBFORM055457
Első szerző:Molnár Péter Pál (pathológus)
Cím:Brain tumors : the relationship between permeability, vascularity and information derived from tumor images / P. P. Molnar, I. Fekete, G. G. Lapin, D. R. Groothuis
Dátum:1988
Tárgyszavak:Orvostudományok Elméleti orvostudományok idézhető absztrakt
Megjelenés:Neuro-Oncology. - 39 (1988), p. 161. -
További szerzők:Fekete István Lapin, Gregory D. Groothuis, Dennis
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5.

001-es BibID:BIBFORM029754
Első szerző:Molnár Péter Pál (pathológus)
Cím:The effects of dexamethasone on experimental brain tumors : I. Transcapillary transport and blood flow in RG-2 rat gliomas / Molnar P., Lapin G. D., Groothuis D. R.
Dátum:1995
ISSN:0167-594X
Megjegyzések:Dexamethasone dramatically improves cerebral edema associated with malignant gliomas. Although the pathophysiology of this effect is not clearly understood, many investigators have postulated that tumor capillary permeability is reduced by dexamethasone. We studied blood-to-tissue transport and blood flow in 178 RG-2 transplanted gliomas in a control group and four groups given dexamethasone at doses of 3, 6, 9, and 12 mg/kg for four days. 14C-alpha aminoisobutyric acid (AIB) was used to study blood-to-tissue transport in 31 animals; in an additional 27 animals 14C-AIB and 131I-iodoantipyrine (IAP) were used in double label experiments to study blood-to-tissue transport and blood flow. Regional measurements of the transfer constant (K) of AIB and blood flow (F) were made with quantitative autoradiography. There were significant differences between the control and dexamethasone-treated groups with regard to weight loss and plasma glucose. However, there was no significant effect of dexamethasone on values of K or F, regardless of the tumor or brain region examined, and regardless of the dose of dexamethasone administered. Analysis of the profiles of the transfer constant of AIB in the brain around tumor showed that the K of AIB decreased within 0.5 mm of the tumor edge in direct relationship to the dexamethasone dose. These results do not support the hypothesis that dexamethasone reduces brain tumor capillary permeability, and suggest that dexamethasone may decrease tumor-associated cerebral edema by effects on bulk flow away from the tumor margin.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Neuro-Oncology. - 25 : 1 (1995), p. 19-28. -
További szerzők:Lapin, Gregory D. Groothuis, Dennis
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6.

001-es BibID:BIBFORM029720
Első szerző:Molnár Péter Pál (pathológus)
Cím:Absence of host-site influence on angiogenesis, blood flow, and permeability in transplanted RG-2 gliomas / Molnar P., Fekete I., Schlageter K. E., Lapin G. D., Groothuis D. R.
Dátum:1999
ISSN:0090-9556
Megjegyzések:The host site is believed to regulate tumor angiogenesis, which could result in site-dependent drug delivery parameters, greatly affecting experimental tumor research. In RG-2 rat gliomas we measured cellular proliferation; cell cycle time was the same for RG-2 cells in brain and s.c. tumors (25 h), and was the same for endothelial cells in these tumors (46 h). We measured the transcapillary transfer constant (K) of alpha-aminoisobutyric acid and blood flow (F) with iodoantipyrine in RG-2 gliomas transplanted into brain, liver, kidney, muscle, s.c. tissue, and into the abdominal cavity. Data was evaluated by quantitative autoradiography and direct tissue sampling. The variation of F (12.6-84.0 ml/g/min) and K (26.1-49.2 microl/g/min) in RG-2 tumors in the different host sites was less than in surrounding tumor-free tissue (F = 20-1500 ml/g/min and K = 1.6-700 microl/g/min). In contrast to other models, RG-2 does not result in tumors with host site-dependent behavior. The RG-2 tumor cells appear to participate in, if not dominate, the angiogenesis process regardless of the host site. Values of F and K were more dependent on tumor topography (center versus periphery) and local histological features (necrosis versus viable tumor) than host site. We believe that the methods used for data acquisition may introduce as much variability in Results as the tumors themselves and that to better understand how tumor angiogenesis affects the vascular phenotype, comparative studies are needed to validate the results obtained with newer methodologies.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Drug Metabolism And Disposition. - 27 : 9 (1999), p. 1085-1091. -
További szerzők:Fekete István (1951-) (neurológus, pszichiáter) Schlageter, Kurt E. Lapin, Gregory D. Groothuis, Dennis
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7.

001-es BibID:BIBFORM029734
Első szerző:Schlageter, Kurt E.
Cím:Microvessel organization and structure in experimental brain tumors : microvessel populations with distinctive structural and functional properties / Schlageter K. E., Molnar P., Lapin G. D., Groothuis D. R.
Dátum:1999
ISSN:0026-2862
Megjegyzések:We studied microvessel organization in five brain tumor models (ENU, MSV, RG-2, S635cl15, and D-54MG) and normal brain, including microvessel diameter (LMVD), intermicrovessel distance (IMVD), microvessel density (MVD), surface area (S(v)), and orientation. LMVD and IMVD were larger and MVD was lower in tumors than normal brain. S(v) in tumors overlapped normal brain values and orientation was random in both tumors and brain. ENU and RG-2 tumors and brain were studied by electron microscopy. Tumor microvessel wall was thicker than that of brain. ENU and normal brain microvessels were continuous and nonfenestrated. RG-2 microvessels contained fenestrations and endothelial gaps; the latter had a maximum major axis of 3.0 microm. Based on anatomic measurements, the pore area of RG-2 tumors was estimated at 7.4 x 10(-6) cm(2) g(-1) from fenestrations and 3.5 x 10(-5) cm(2) g(-1) from endothelial gaps. Increased permeability of RG-2 microvessels to macromolecules is most likely attributable to endothelial gaps. Three microvessel populations may occur in brain tumors: (1) continuous nonfenestrated, (2) continuous fenestrated, and (3) discontinuous (with or without fenestrations). The first group may be unique to brain tumors; the latter two are similar to microvessels found in systemic tumors. Since structure-function properties of brain tumor microvessels will affect drug delivery, studies of microvessel function should be incorporated into clinical trials of brain tumor therapy, especially those using macromolecules.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Microvascular Research. - 58 : 3 (1999), p. 312-328. -
További szerzők:Molnár Péter Pál (1951-) (pathológus) Lapin, Gregory D. Groothuis, Dennis
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8.

001-es BibID:BIBFORM029755
Első szerző:Warnke, Peter C.
Cím:The effects of dexamethasone on transcapillary transport in experimental brain tumors : II. Canine brain tumors / Warnke P. C., Molnar P., Lapin G. D., Kuruvilla A., Groothuis D. R.
Dátum:1995
ISSN:0167-594X
Megjegyzések:We studied the effect of dexamethasone on transcapillary transport in ten Avian Sarcoma Virus (ASV)-induced canine brain tumors, before and one week after administration of dexamethasone, 2.5 mg/kg/day. A computed tomographic (CT) method was used to measure regional values of K1 (blood-to-tissue transfer constant), k2 (tissue-to-blood efflux constant), and Vp (tissue plasma vascular space) of meglumine iothalamate (Conray-60); the values were reconstructed for each 0.8 x 0.8 x 5 mm volume element of the CT data. For all tumors considered together, there was a decrease in the whole tumor K1 value of meglumine iothalamate from 26 +/- 2.2 (SE) before dexamethasone to 24 +/- 2.9 microliters/g/min after dexamethasone. Vp decreased from 7.2 +/- 0.7 to 6.7 +/- 0.9 ml/100 g, and the size of the tumor extracellular space (Ve) decreased from 0.30 to 0.26 ml/g. These changes were not statistically significant. However, when each tumor was used as its own control, K1 significantly decreased after dexamethasone in four tumors, significantly increased in two and was unchanged in four. These results suggest that decreased blood-to-tissue transport may be one mechanism underlying resolution of tumor associated cerebral edema in some brain tumors and that the effects of dexamethasone on blood-to-tissue transport in brain tumors are variable from one tumor to the next. Decreased 'permeability' may not be the sole mechanism by which dexamethasone reduces tumor-associated cerebral edema.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Neuro-Oncology. - 25 : 1 (1995), p. 29-38. -
További szerzők:Molnár Péter Pál (1951-) (pathológus) Lapin, Gregory D. Kuruvilla, A. Groothuis, Dennis
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