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1.

001-es BibID:BIBFORM029746
Első szerző:Groothuis, Dennis
Cím:Hyperosmotic Blood-Brain Barrier Disruption : reply / Dennis Groothuis, Gregory Lapin, Peter Warnke, Peter Molnar
Dátum:1990
ISSN:0022-3085
Tárgyszavak:Orvostudományok Klinikai orvostudományok levél
Megjelenés:Journal Of Neurosurgery. - 73 : 5 (1990), p. 806-807. -
További szerzők:Lapin, Gregory D. Warnke, Peter C. Molnár Péter Pál (1951-) (pathológus)
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DOI
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2.

001-es BibID:BIBFORM029745
Első szerző:Groothuis, Dennis
Cím:Blood-brain barrier disruption in brain-tumor therapy / Dennis R. Groothuis, Peter C. Warnke, Peter Molnar, Gregory D. Lapin, Michael A. Mikhael.
Dátum:1990
Tárgyszavak:Orvostudományok Klinikai orvostudományok levél
Megjelenés:Journal of Neurosurgery. - 73 : 3 (1990), p. 476-477. -
További szerzők:Warnke, Peter C. Molnár Péter Pál (1951-) (pathológus) Lapin, Gregory D. Mikhael, Michael A.
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DOI
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3.

001-es BibID:BIBFORM029733
Első szerző:Groothuis, Dennis
Cím:Effect of hyperosmotic blood-brain barrier disruption on transcapillary transport in canine brain tumors / Groothuis Dennis R., Warnke Peter C., Molnar Peter, Lapin Gregory D., Mikhael Michael A.
Dátum:1990
ISSN:0022-3085
Megjegyzések:Whether hyperosmotic blood-brain barrier (BBB) disruption is a technique that can be used to increase permeability of brain-tumor capillaries and thereby transiently increase drug delivery to the brain tumor is controversial. Nine virally induced brain tumors were studied in seven dogs, before and after hyperosmotic BBB disruption with 1.4 osmolar mannitol. Each dog was studied with computerized tomography (CT) after administration of the water-soluble tracer meglumine iothalamate. Each study lasted 30 minutes. A baseline CT scan and 35 to 40 additional CT scans were obtained to provide a time-related measurement of the amount of meglumine iothalamate in tissue (Am(t], and 30 plasma samples were collected to provide the time-related measurement of meglumine iothalamate in plasma (Cp(t]. The data were analyzed by three different methods: 1) a two-compartment model and nonlinear curve fitting were used to calculate K1 (blood-to-tissue or influx constant), k2 (tissue-to-blood or efflux constant), and Vp (plasma vascular space); 2) K1 values were calculated with a two-compartment model, assuming no efflux, at the time point for each CT scan; and 3) a "tissue advantage ratio" was calculated that expressed the ratio of tissue uptake of meglumine iothalamate at each time point, comparing values before and after BBB disruption. Regardless of which method of data analysis was used, there was a marked and significant increase in transcapillary transport of meglumine iothalamate to tumor-free brain regions, while there was only a small, transient, and insignificant increase to the brain tumors. Although there were often marked increases in delivery to cortex in the same hemisphere as the tumors, there was no significant increase to brain immediately surrounding the tumors, perhaps due to altered circulatory dynamics in this region. These data raise serious questions as to the wisdom of using this technique to increase drug delivery to brain tumors in patients and strongly support the continued study of this technique in experimental brain tumors before it is used in patients.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Neurosurgery. - 72 : 3 (1990), p. 441-449. -
További szerzők:Warnke, Peter C. Molnár Péter Pál (1951-) (pathológus) Lapin, Gregory D. Mikhael, Michael A.
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DOI
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4.

001-es BibID:BIBFORM029755
Első szerző:Warnke, Peter C.
Cím:The effects of dexamethasone on transcapillary transport in experimental brain tumors : II. Canine brain tumors / Warnke P. C., Molnar P., Lapin G. D., Kuruvilla A., Groothuis D. R.
Dátum:1995
ISSN:0167-594X
Megjegyzések:We studied the effect of dexamethasone on transcapillary transport in ten Avian Sarcoma Virus (ASV)-induced canine brain tumors, before and one week after administration of dexamethasone, 2.5 mg/kg/day. A computed tomographic (CT) method was used to measure regional values of K1 (blood-to-tissue transfer constant), k2 (tissue-to-blood efflux constant), and Vp (tissue plasma vascular space) of meglumine iothalamate (Conray-60); the values were reconstructed for each 0.8 x 0.8 x 5 mm volume element of the CT data. For all tumors considered together, there was a decrease in the whole tumor K1 value of meglumine iothalamate from 26 +/- 2.2 (SE) before dexamethasone to 24 +/- 2.9 microliters/g/min after dexamethasone. Vp decreased from 7.2 +/- 0.7 to 6.7 +/- 0.9 ml/100 g, and the size of the tumor extracellular space (Ve) decreased from 0.30 to 0.26 ml/g. These changes were not statistically significant. However, when each tumor was used as its own control, K1 significantly decreased after dexamethasone in four tumors, significantly increased in two and was unchanged in four. These results suggest that decreased blood-to-tissue transport may be one mechanism underlying resolution of tumor associated cerebral edema in some brain tumors and that the effects of dexamethasone on blood-to-tissue transport in brain tumors are variable from one tumor to the next. Decreased 'permeability' may not be the sole mechanism by which dexamethasone reduces tumor-associated cerebral edema.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Neuro-Oncology. - 25 : 1 (1995), p. 29-38. -
További szerzők:Molnár Péter Pál (1951-) (pathológus) Lapin, Gregory D. Kuruvilla, A. Groothuis, Dennis
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5.

001-es BibID:BIBFORM029740
Első szerző:Warnke, Peter C.
Cím:Intravenous adenosine selectively increases blood flow to xenotransplanted intracerebral gliomas / Warnke P. C., Molnar P., Bigner D. D., Heistad D. H., Groothuis D. R.
Dátum:1987
ISSN:0028-3878
Megjegyzések:Adenosine was infused intravenously at 10 mumol/(kg.min) into athymic ("nude") rats with intracerebral D-54MG xenotransplanted brain tumors, in an attempt to increase tumor blood flow. Cerebral blood flow (F) was measured with 14C-iodoantipyrine and quantitative autoradiography. Mean arterial blood pressure was 95 +/- 9.4 (SE) mm Hg in the adenosine group and 112 +/- 6.0 mm Hg in the controls. Averaged mean whole tumor F was significantly higher in adenosine-treated brain tumors (117.6 +/- 20.8 ml/[hg.min]) than in controls (62.2 +/- 9.7 ml/[hg.min]). Regionally, there were significant increases of F in tumor periphery and brain around tumor, but not in tumor center or any tumor-free brain regions. Focal values of F less than 5 ml/(hg.min) were present in some necrotic regions of adenosine-treated tumors. These results, obtained in unanesthetized rats with transplanted gliomas from a human cell line, confirm our earlier observations in avian sarcoma virus-induced brain sarcomas in dogs, and suggest that adenosine or perhaps other vasodilators could be used to selectively increase the delivery of lipid-soluble chemotherapeutic drugs to brain tumors.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Neurology. - 37 : 12 (1987), p. 1870-1873. -
További szerzők:Molnár Péter Pál (1951-) (pathológus) Bigner, Darell Heistad, D. H. Groothuis, Dennis
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