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001-es BibID:	BIBFORM090166
Első szerző:	Hágendorn Roland
Cím:	Disturbance of consciousness deteriorates the severity of acute pancreatitis. An international multicentre cohort analyses of 1220 prospectively collected patients / R. Hagendorn, Á. Vincze, F. Izbeki, L. Gajdan, S. Godi, A. Illes, P. Sarlos, N. Farkas, B. Erős, V. Lillik, D. Illes, P. Varjú, K. Marta, I. Török, M. Papp, Z. Vitalis, B. Bod, J. Hamvas, Z. Szepes, T. Takacs, L. Czakó, A. Szentesi, A. Parniczky, P. Hegyi, A. Miko
Dátum:	2020
ISSN:	1424-3903
Megjegyzések:	Purpose: Disturbance of consciousness (DOC) may develop in acute pancreatitis (AP). In clinical practice, it is known that DOC may worsen the patient's condition, but we have no exact data on how DOC affects the outcome of AP. Materials and methods: From the Hungarian Pancreatic Study Groups' AP registry, 1220 cases contained the exact data on DOC. Patients were separated to Non-DOC and DOC, whereas DOC was further divided into non-alcohol related DOC (Non-ALC DOC) and ALC-DOC groups. Statistical analysis was performed by SPSS 24 Software Package. Results: From the 1220 patients, 47 (3.85%) developed DOC, 23 (48.9%) cases were ALC DOC vs. 24 (51.1%) Non-ALC DOC. The incidence of severe AP was higher in the DOC compared to the Non-DOC group (19.15% vs. 5.29%, p<0.001). The mortality was higher in the DOC vs. Non-DOC group (14.89% vs. 1.71%, p<0.001). Length of hospitalization (LOH) was longer in the DOC vs. non-DOC group (Me:11; IQR:8-17 days vs. Me:9; IQR:6-13 days, p?0.049). Patients with ALC DOC developed more frequently moderately-severe AP vs. Non-ALC DOC (43.48% vs. 12.5%), while the incidence of severe AP was significantly higher in Non-ALC vs. ALC DOC group (33.33% vs. 4.35%) (p<0.001). LOH showed tendency to be longer in Non-ALC DOC compared to ALC DOC respectively (Me:13; IQR:7-20 days vs. Me:9.5; IQR:8-15.5 days, p?0.119). Conclusions: DOC during AP is associated with a higher rate of moderate and severe AP and increases the risk of mortality; therefore, the DOC should be closely monitored and prevented in AP.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt folyóiratcikk
Megjelenés:	Pancreatology. - 20 (2020), p. S25. -
További szerzők:	Vincze Áron Izbéki Ferenc Gajdán László Gódi Szilárd Illés Árpád (1959-) (belgyógyász, haematológus, onkológus) Sarlós Péter Farkas Nelli Erős Bálint Lillik Veronika Illés Dóra Varjú Péter Márta Katalin Török I. Papp Mária (1975-) (belgyógyász, gasztroenterológus) Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus) Bod Barnabás Hamvas József Szepes Zoltán Takács T. Czakó László Szentesi Andrea Párniczky Andrea (gyermekgyógyász) Hegyi Péter Jenő (belgyógyász) Mikó Alexandra
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM085501
Első szerző:	Hágendorn Roland
Cím:	Development of disturbance of consciousness is associated with increased severity in acute pancreatitis / Roland Hágendorn, Áron Vincze, Ferenc Izbéki, László Gajdán, Szilárd Gódi, Anita Illés, Patrícia Sarlós, Nelli Farkas, Bálint Erőss, Veronika Lillik, Dóra Illés, Péter Varjú, Katalin Márta, Imola Török, Mária Papp, Zsuzsanna Vitális, Barnabás Bod, József Hamvas, Zoltán Szepes, Tamás Takács, László Czakó, Zsolt Márton, Andrea Szentesi, Andrea Párniczky, Péter Hegyi, Alexandra Mikó
Dátum:	2020
ISSN:	1424-3903
Megjegyzések:	Background Disturbance of consciousness (DOC) may develop in acute pancreatitis (AP). In clinical practice, it is known that DOC may worsen the patient's condition, but we have no exact data on how DOC affects the outcome of AP. Methods From the Hungarian Pancreatic Study Groups' AP registry, 1220 prospectively collected cases were analysed, which contained exact data on DOC, included patients with confusion, delirium, convulsion, and alcohol withdrawal, answering a post hoc defined research question. Patients were separated to Non-DOC and DOC, whereas DOC was further divided into non-alcohol related DOC (Non-ALC DOC) and ALC DOC groups. For statistical analysis, independent sample t-test, Mann-Whitney, Chi-squared, or Fisher exact test were used. Results From the 1220 patients, 47 (3.9%) developed DOC, 23 (48.9%) cases were ALC DOC vs. 24 (51.1%) Non-ALC DOC. Analysis between the DOC and Non-DOC groups showed a higher incidence of severe AP (19.2% vs. 5.3%, p<0.001), higher mortality (14.9% vs. 1.7%, p<0.001), and a longer length of hospitalization (LOH) (Me=11; IQR: 8-17 days vs. Me=9; IQR: 6-13 days, p=0.049) respectively. Patients with ALC DOC developed more frequently moderate AP vs. Non-ALC DOC (43.5% vs. 12.5%), while the incidence of severe AP was higher in Non-ALC vs. ALC DOC group (33.3% vs. 4.4%) (p<0.001). LOH showed a tendency to be longer in Non-ALC DOC compared to ALC DOC, respectively (Me:13; IQR:7-20 days vs. Me:9.5; IQR:8-15.5 days, p=0.119). Conclusion DOC during AP is associated with a higher rate of moderate and severe AP and increases the risk of mortality.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk disturbance of consciousness acute pancreatitis alcohol delirium mortality
Megjelenés:	Pancreatology. - 20 : 5 (2020), p. 806-812. -
További szerzők:	Vincze Áron Izbéki Ferenc Gajdán László Gódi Szilárd Illés Anita Sarlós Patrícia Farkas Nelli Erőss Bálint Lillik Veronika Illés Dóra Varjú Péter Márta Katalin Török Imola Papp Mária (1975-) (belgyógyász, gasztroenterológus) Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus) Bod Barnabás Hamvas József Szepes Zoltán Takács Tamás (Szeged) Czakó László Márton Zsolt Szentesi Andrea Párniczky Andrea (gyermekgyógyász) Hegyi Péter Jenő (belgyógyász) Mikó Alexandra
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM134142
035-os BibID:	(scopus)85213515974 (wos)001424205100001
Első szerző:	Hussein Tamás
Cím:	Onset of pancreatic cancer before and after acute pancreatitis: A multicenter longitudinal cohort study / Hussein Tamás, Mátrai Péter, Vass Vivien, Szentesi Andrea, Hegyi Péter, Hungarian Pancreatic Study Group
Dátum:	2025
ISSN:	1424-3903
Megjegyzések:	Abstract Background: Pancreatic cancer (PC) is a leading cause of cancer mortality, often diagnosed at advanced stages. Acute pancreatitis (AP), particularly idiopathic cases, may serve as an early indicator of PC. Objective: This multicenter cohort study investigated the incidence of PC before and after an AP episode, focusing on idiopathic AP and the role of pseudocysts as potential early markers for PC development. Methods: We analyzed data from 2356 AP patients across 25 centers, with a median follow-up of 4.1 years (IQR: 1.6-6.8 years). Patients were categorized into 'PC before AP' and 'PC after AP' groups, and relative risk (RR) and adjusted odds ratios (OR) were calculated for idiopathic AP cases to quantify PC risk. Results: Among all cases, 69 patients (2.9 %) developed PC: 1.4 % (n = 34) before and 1.5 % (n = 35) after AP. Idiopathic AP cases had a fourfold higher risk of PC (OR = 4.46, [2.25-8.85]). Notably, pseudocysts were five times more prevalent in the PC group (14 %) compared to controls (3 %) (RR = 5.66; p < 0.01), often located at the tumor site. PC developed in 3 % of idiopathic AP cases versus 1.0 % in non-idiopathic cases. The median time to PC diagnosis post-AP was 373 days. Conclusion: Idiopathic AP and pseudocyst formation significantly elevate the risk of PC, particularly within two years. These findings underscore the need for structured follow-up and early screening in idiopathic AP cases to improve PC detection and survival outcomes.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Acute pancreatitis Follow-up Idiopathic Pancreatic cancer Risk factors
Megjelenés:	Pancreatology. - 25 : 1 (2025), p. 29-34. -
További szerzők:	Mátrai Péter Vass Vivien Szentesi Andrea Hegyi Péter Jenő (belgyógyász) Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus) Papp Mária (1975-) (belgyógyász, gasztroenterológus) Hungarian Pancreatic Study Group
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