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001-es BibID:	BIBFORM040618
Első szerző:	Papp Zoltán (kardiológus, élettanász)
Cím:	Levosimendan : molecular mechanisms and clinical implications Consensus of experts on the mechanisms of action of levosimendan / Papp Z., Édes I., Fruhwald S., De Hert S. G., Salmenperä M., Leppikangas H., Mebazaa A., Landoni G., Grossini E., Caimmi P., Morelli A., Guarracino F., Schwinger R. H., Meyer S., Algotsson L., Wikström B. G., Jörgensen K., Filippatos G., Parissis J. T., González M. J., Parkhomenko A., Yilmaz M. B., Kivikko M., Pollesello P., Follath F.
Dátum:	2012
Megjegyzések:	The molecular background of the Ca(2+)-sensitizing effect of levosimendan relates to its specific interaction with the Ca(2+)-sensor troponin C molecule in the cardiac myofilaments. Over the years, significant preclinical and clinical evidence has accumulated and revealed a variety of beneficial pleiotropic effects of levosimendan and of its long-lived metabolite, OR-1896. First of all, activation of ATP-sensitive sarcolemmal K(+) channels of smooth muscle cells appears as a powerful vasodilator mechanism. Additionally, activation of ATP-sensitive K(+) channels in the mitochondria potentially extends the range of cellular actions towards the modulation of mitochondrial ATP production and implicates a pharmacological mechanism for cardioprotection. Finally, it has become evident, that levosimendan possesses an isoform-selective phosphodiesterase-inhibitory effect. Interpretation of the complex mechanism of levosimendan action requires that all potential pharmacological interactions are analyzed carefully in the framework of the currently available evidence. These data indicate that the cardiovascular effects of levosimendan are exerted via more than an isolated drug-receptor interaction, and involve favorable energetic and neurohormonal changes that are unique in comparison to other types of inodilators.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	International Journal of Cardiology. - 159 : 2 (2012), p. 82-87. -
További szerzők:	Édes István (1952-) (kardiológus) Fruhwald, Sonja De Hert, Stefan G. Salmenperä, Markku Leppikangas, Heli Mebazaa, Alexandre Landoni, Giovanni Grossini, Elena Caimmi, Philippe Morelli, Andrea Guarracino, Fabio Schwinger, Robert H. G. Meyer, Sven Algotsson, Lars Wikström, Gerhard Jörgensen, Kirsten Filippatos, Gerasimos S. Parissis, John González, Martín J. Parkhomenko, Alexander Yilmaz, Mehmet Birhan Kivikko, Matti Pollesello, Piero Follath Ferenc
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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