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001-es BibID:	BIBFORM070104
035-os BibID:	(Wos)000405571400002 (Scopus)85020004824
Első szerző:	Harjola, Veli-Pekka
Cím:	Organ dysfunction, injury and failure in acute heart failure : from pathophysiology to diagnosis and management. A review on behalf of the Acute Heart Failure Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC) / Harjola Veli-Pekka, Mullens Wilfried, Banaszewski Marek, Bauersachs Johann, Brunner-La Rocca Hans-Peter, Chioncel Ovidiu, Collins Sean P., Doehner Wolfram, Filippatos Gerasimos S., Flammer Andreas J., Fuhrmann Valentin, Lainscak Mitja, Lassus Johan, Legrand Matthieu, Masip Josep, Mueller Christian, Papp Zoltán, Parissis John, Platz Elke, Rudiger Alain, Ruschitzka Frank, Schäfer Andreas, Seferovic Petar M., Skouri Hadi, Yilmaz Mehmet Birhan, Mebazaa Alexandre
Dátum:	2017
ISSN:	1388-9842
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	European Journal Of Heart Failure. - 19 : 7 (2017), p. 821-836. -
További szerzők:	Mullens, Wilfried Banaszewski, Marek Bauersachs, Johann Brunner-La Rocca, Hans-Peter Chioncel, Ovidiu Collins, Sean P. Doehner, Wolfram Filippatos, Gerasimos S. Flammer, Andreas J. Fuhrmann, Valentin Lainscak, Mitja Lassus, Johan Legrand, Matthieu Masip, Josep Mueller, Christian Papp Zoltán (1965-) (kardiológus, élettanász) Parissis, John Platz, Elke Rudiger, Alain Ruschitzka, Frank Schäfer, Andreas Seferović, Petar M. Skouri, Hadi Yilmaz, Mehmet Birhan Mebazaa, Alexandre
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001-es BibID:	BIBFORM076736
035-os BibID:	(WoS)000501730100012 (Scopus)85075326564
Első szerző:	Maack, Christoph
Cím:	Treatments targeting inotropy : a position paper of the Committees on Translational Research and Acute Heart Failure of the Heart Failure Association of the European Society of Cardiology / Christoph Maack, Thomas Eschenhagen, Nazha Hamdani, Frank R. Heinzel, Alexander R. Lyon, Dietmar J. Manstein, Joseph Metzger, Zoltán Papp, Carlo G. Tocchetti, M. Birhan Yilmaz, Stefan D. Anker, Jean-Luc Balligand, Johann Bauersachs, Dirk Brutsaert, Lucie Carrier, Stefan Chlopicki, John G. Cleland, Rudolf A. de Boer, Alexander Dietl, Rodolphe Fischmeister, Veli-Pekka Harjola, Stephane Heymans, Denise Hilfiker-Kleiner, Johannes Holzmeister, Gilles de Keulenaer, Giuseppe Limongelli, Wolfgang A. Linke, Lars H. Lund, Josep Masip, Marco Metra, Christian Mueller, Burkert Pieske, Piotr Ponikowski, Arsen Ristic, Frank Ruschitzka, Petar M. Seferovic, Hadi Skouri, Wolfram H. Zimmermann, Alexandre Mebazaa
Dátum:	2019
ISSN:	0195-668X
Megjegyzések:	Acute heart failure (HF) and in particular, cardiogenic shock are associated with high morbidity and mortality. A therapeutic dilemma is that the use of positive inotropic agents, such as catecholamines or phosphodiesterase-inhibitors, is associated with increased mortality. Newer drugs, such as levosimendan or omecamtiv mecarbil, target sarcomeres to improve systolic function putatively without elevating intracellular Ca2+. Although meta-analyses of smaller trials suggested that levosimendan is associated with a better outcome than dobutamine, larger comparative trials failed to confirm this observation. For omecamtiv mecarbil, Phase II clinical trials suggest a favourable haemodynamic profile in patients with acute and chronic HF, and a Phase III morbidity/mortality trial in patients with chronic HF has recently begun. Here, we review the pathophysiological basis of systolic dysfunction in patients with HF and the mechanisms through which different inotropic agents improve cardiac function. Since adenosine triphosphate and reactive oxygen species production in mitochondria are intimately linked to the processes of excitation-contraction coupling, we also discuss the impact of inotropic agents on mitochondrial bioenergetics and redox regulation. Therefore, this position paper should help identify novel targets for treatments that could not only safely improve systolic and diastolic function acutely, but potentially also myocardial structure and function over a longer-term.
Tárgyszavak:	idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Heart failure Acute decompensated heart failure Inotropes Cardiogenic shock Excitation-contraction coupling Calcium Sarcomeres Mitochondria Energetics Adrenergic receptors Contractility Levosimendan Omecamtiv mecarbil Nitroxyl
Megjelenés:	European Heart Journal. - 40 : 44 (2019), p. 3626-3640. -
További szerzők:	Eschenhagen, Thomas Hamdani, Nazha Heinzel, Frank R. Lyon, Alexander Manstein, Dietmar J. Metzger József Papp Zoltán (1965-) (kardiológus, élettanász) Tocchetti, Carlo Gabriele Yilmaz, Mehmet Birhan Anker, Stefan D. Balligand, Jean-Luc Bauersachs, Johann Brutsaert, Dirk L. Carrier, Lucie Chlopicki, Stefan Cleland, John G. Boer, Rudolf A. de Dietl, Alexander Fischmeister, Rodolphe Harjola, Veli-Pekka Heymans, Stephane Hilfiker-Kleiner, Denise Holzmeister, Johannes De Keulenaer, Gilles Limongelli, Giuseppe Linke, Wolfgang A. Lund, Lars H. Masip, Josep Metra, Marco Mueller, Christian Pieske, Burkert Ponikowski, Piotr Ristić, Arsen D. Ruschitzka, Frank Seferović, Petar M. Skouri, Hadi Zimmermann, Wolfram H. Mebazaa, Alexandre
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001-es BibID:	BIBFORM070112
Első szerző:	Seferović, Petar M.
Cím:	Organization of heart failure management in European Society of Cardiology member countries : survey of the Heart Failure Association of the European Society of Cardiology in collaboration with the Heart Failure National Societies/Working Groups / Seferović Petar M., Stoerk Stefan, Filippatos Gerasimos, Mareev Viacheslav, Kavoliuniene Ausra, Ristić Arsen D., Ponikowski Piotr, McMurray John, Maggioni Aldol, Ruschitzka Frankl, van Veldhuisen Dirk J., Coats Andrew, Piepoli Massimo, McDonagh Theresa, Riley Jillian, Hoes Arno, Pieske Burkert, Dobrić Milan, Papp Zoltan, Mebazaa Alexandre, Parissis John, Ben Gal Tuvia, Vinereanu Dragos, Brito Dulce, Altenberger Johann, Gatzov Plamen, Milinković Ivan, Hradec Jaromír, Trochu Jean-Noel, Amir Offer, Moura Brenda, Lainscak Mitja, Comin Josep, Wikström Gerhard, Anker Stefan, Committee of National Heart Failure Societies or Working Groups of the Heart Failure Association of the European Society of Cardiology
Dátum:	2013
ISSN:	1388-9842
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	European Journal Of Heart Failure. - 15 : 9 (2013), p. 947-959. -
További szerzők:	Stoerk, Stefan Filippatos, Gerasimos S. Mareev, Vyacheslev Kavoliuniene, Ausra Ristić, Arsen D. Ponikowski, Piotr McMurray, John J. Maggioni, Aldo Ruschitzka, Frank van Veldhuisen, Dirk J. Coats, Andrew Piepoli, Massimo McDonagh, Theresa Riley, Jillian Hoes, Arno Pieske, Burkert Dobrić, Milan Papp Zoltán (1965-) (kardiológus, élettanász) Mebazaa, Alexandre Parissis, John Ben Gal, Tuvia Vinereanu, Dragos Brito, Dulce Altenberger, Johann Gatzov, Plamen Milinković, Ivan Hradec, Jaromír Trochu, Jean-Noel Amir, Offer Moura, Brenda Lainscak, Mitja Comin-Colet, Josep Wikström, Gerhard Anker, Stefan D. Committee of NHFS or WGHFA of the ESC
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