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001-es BibID:	BIBFORM120802
035-os BibID:	(Scopus)85191357998 (WoS)001205799400001
Első szerző:	Ameri, Pietro
Cím:	A roadmap for therapeutic discovery in pulmonary hypertension associated with left heart failure. A scientific statement of the Heart Failure Association (HFA) of the ESC and the ESC Working Group on Pulmonary Circulation & Right Ventricular Function / Pietro Ameri, Valentina Mercurio, Piero Pollesello, Markus S. Anker, Johannes Backs, Antoni Bayes-Genis, Barry A. Borlaug, Daniel Burkhoff, Sergio Caravita, Stephen Y. Chan, Frances de Man, George Giannakoulas, Aránzazu González, Marco Guazzi, Paul M. Hassoun, Anna R. Hemnes, Cristoph Maack, Brendan Madden, Vojtech Melenovsky, Oliver J. Müller, Zoltan Papp, Soni Savai Pullamsetti, Peter P. Rainer, Margaret M. Redfield, Stuart Rich, Gabriele G. Schiattarella, Hall Skaara, Kostantinos Stellos, Ryan J. Tedford, Thomas Thum, Jean Luc Vachiery, Peter van der Meer, Sophie Van Linthout, Piotr Pruszczyk, Petar Seferovic, Andrew J. S. Coats, Marco Metra, Giuseppe Rosano, Stephan Rosenkranz, Carlo Gabriele Tocchetti
Dátum:	2024
ISSN:	1388-9842 1879-0844
Megjegyzések:	Pulmonary hypertension (PH) associated with left heart failure (LHF) (PH-LHF) is one of the most common causes of PH. It directly contributes to symptoms and reduced functional capacity and negatively affects right heart function, ultimately leading to a poor prognosis. There are no specific treatments for PH-LHF, despite the high number of drugs tested so far. This scientific document addresses the main knowledge gaps in PH-LHF with emphasis on pathophysiology and clinical trials. Key identified issues include better understanding of the role of pulmonary venous versus arteriolar remodelling, multidimensional phenotyping to recognize patient subgroups positioned to respond to different therapies, and conduct of rigorous pre-clinical studies combining small and large animal models. Advancements in these areas are expected to better inform the design of clinical trials and extend treatment options beyond those effective in pulmonary arterial hypertension. Enrichment strategies, endpoint assessments, and thorough haemodynamic studies, both at rest and during exercise, are proposed to play primary roles to optimize early-stage development of candidate therapies for PH-LHF.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Drug Heart failure Pulmonary hypertension Therapy Translational
Megjelenés:	European Journal Of Heart Failure. - 26 : 4 (2024), p. 707-729. -
További szerzők:	Mercurio, Valentina Pollesello, Piero Anker, Markus S. Backs, Johannes Bayes-Genis, Antoni Borlaug, Barry A. Burkhoff, Daniel Caravita, Sergio Chan, Stephen Man, Frances de Giannakoulas, George González, Aránzazu Guazzi, Marco Hassoun, Paul M. Hemnes, Anna R. Maack, Christoph Madden, Brendan Melenovsky, Vojtech Müller, Oliver J. Papp Zoltán (1965-) (kardiológus, élettanász) Pullamsetti, Soni Savai Rainer, Peter P. Redfield, Margaret M. Rich, Stuart Schiattarella, Gabriele G. Skaara, Hall Stellos, Kostantinos Tedford, Ryan J. Thum, Thomas Vachiery, Jean Luc Meer, Peter van der Linthout, Sophie Van Pruszczyk, Piotr Seferović, Petar M. Coats, Andrew Metra, Marco Rosano, Giuseppe M. C. Rosenkranz, Stephan Tocchetti, Carlo Gabriele
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001-es BibID:	BIBFORM125677
035-os BibID:	(scopus)85196289402 (wos)001250584500001
Első szerző:	Seferović, Petar M.
Cím:	Diabetic myocardial disorder. A clinical consensus statement of the Heart Failure Association of the ESC and the ESC Working Group on Myocardial & Pericardial Diseases / Seferovic Petar M., Paulus Walter J., Rosano Giuseppe, Polovina Marija, Petrie Mark C., Jhund Pardeep S., Tschöpe Carsten, Sattar Naveed, Piepoli Massimo, Papp Zoltán, Standl Eberhard, Mamas Mamas A., Valensi Paul, Linhart Ales, Lalic Nebojsa, Ceriello Antonio, Döhner Wolfram, Ristic, Arsen, Milinkovic Ivan, Seferovic Jelena, Cosentino Francesco, Metra Marco, Coats Andrew J. S.
Dátum:	2024
ISSN:	1388-9842 1879-0844
Megjegyzések:	The association between type 2 diabetes mellitus (T2DM) and heart failure (HF) has been firmly established; however, the entity of diabetic myocardial disorder (previously called diabetic cardiomyopathy) remains a matter of debate. Diabetic myocardial disorder was originally described as the occurrence of myocardial structural/functional abnormalities associated with T2DM in the absence of coronary heart disease, hypertension and/or obesity. However, supporting evidence has been derived from experimental and small clinical studies. Only a minority of T2DM patients are recognized as having this condition in the absence of contributing factors, thereby limiting its clinical utility. Therefore, this concept is increasingly being viewed along the evolving HF trajectory, where patients with T2DM and asymptomatic structural/functional cardiac abnormalities could be considered as having pre-HF. The importance of recognizing this stage has gained interest due to the potential for current treatments to halt or delay the progression to overt HF in some patients. This document is an expert consensus statement of the Heart Failure Association of the ESC and the ESC Working Group on Myocardial & Pericardial Diseases. It summarizes contemporary understanding of the association between T2DM and HF and discuses current knowledge and uncertainties about diabetic myocardial disorder that deserve future research. It also proposes a new definition, whereby diabetic myocardial disorder is defined as systolic and/or diastolic myocardial dysfunction in the presence of diabetes. Diabetes is rarely exclusively responsible for myocardial dysfunction, but usually acts in association with obesity, arterial hypertension, chronic kidney disease and/or coronary artery disease, causing additive myocardial impairment.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Diabetic myocardial disorder Type 2 diabetes mellitus Heart failure Cardiac abnormalities Risk assessment Prevention Treatment
Megjelenés:	European Journal Of Heart Failure. - 26 (2024), p. 1893-1903. -
További szerzők:	Paulus, Walter J. Rosano, Giuseppe M. C. Polovina, Marija Petrie, Mark C. Jhund, Pardeep S. Tschöpe, Carsten Sattar, Naveed Piepoli, Massimo Papp Zoltán (1965-) (kardiológus, élettanász) Standl, Eberhard Mamas, Mamas A. Valensi, Paul Linhart, Ales Lalić, Nebojša Ceriello, Antonio Döhner, Wolfram Ristić, Arsen D. Milinković, Ivan Seferović, Jelena Cosentino, Francesco Metra, Marco Coats, Andrew
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001-es BibID:	BIBFORM082736
035-os BibID:	(PMID)30957868 (WoS)000490139300015 (Scopus)85068687380
Első szerző:	Triposkiadis, Filippos
Cím:	The continuous heart failure spectrum : moving beyond an ejection fraction classification / Filippos Triposkiadis, Javed Butler, Francois M. Abboud, Paul W. Armstrong, Stamatis Adamopoulos, John J. Atherton, Johannes Backs, Johann Bauersachs, Daniel Burkhoff, Robert O. Bonow, Vijay K. Chopra, Rudolf A. de Boer, Leon de Windt, Nazha Hamdani, Gerd Hasenfuss, Stephane Heymans, Jean-Sébastien Hulot, Marvin Konstam, Richard T. Lee, Wolfgang A. Linke, Ida G. Lunde, Alexander R. Lyon, Christoph Maack, Douglas L. Mann, Alexandre Mebazaa, Robert J. Mentz, Petros Nihoyannopoulos, Zoltan Papp, John Parissis, Thierry Pedrazzini, Giuseppe Rosano, Jean Rouleau, Petar M. Seferovic, Ajay M. Shah, Randall C. Starling, Carlo G. Tocchetti, Jean-Noel Trochu, Thomas Thum, Faiez Zannad, Dirk L. Brutsaert, Vincent F. Segers, Gilles W. De Keulenaer
Dátum:	2019
ISSN:	0195-668X
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	European Heart Journal. - 40 : 26 (2019), p. 2155-2163. -
További szerzők:	Butler, Javed Abboud, Francois M. Armstrong, Paul W. Adamopoulos, Stamatis Atherton, John J. Backs, Johannes Bauersachs, Johann Burkhoff, Daniel Bonow, Robert O. Chopra, Vijay K. Boer, Rudolf A. de Windt, Leon de Hamdani, Nazha Hasenfuß, Gerd Heymans, Stephane Hulot, Jean-Sébastien Konstam, Marvin Lee, Richard T. Linke, Wolfgang A. Lunde, Ida G. Lyon, Alexander Maack, Christoph Mann, Douglas L. Mebazaa, Alexandre Mentz, Robert J. Nihoyannopoulos, Petros Papp Zoltán (1965-) (kardiológus, élettanász) Parissis, John Pedrazzini, Thierry Rosano, Giuseppe M. C. Rouleau, Jean-Lucien Seferović, Petar M. Shah, Ajay M. Starling, Randall C. Tocchetti, Carlo Gabriele Trochu, Jean-Noel Thum, Thomas Zannad, Faiez Brutsaert, Dirk L. Segers, Vincent F. De Keulenaer, Gilles
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