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001-es BibID:	BIBFORM111677
035-os BibID:	(cikkazonosító)7453 (scopus)85133348910 (wos)000825631600001
Első szerző:	Szabó Gábor Tamás (kardiológus)
Cím:	Improvement of Left Ventricular Graft Function Using an Iron-Chelator-Supplemented Bretschneider Solution in a Canine Model of Orthotopic Heart Transplantation / Szabó Gábor, Loganathan Sivakkanan, Korkmaz-Icöz Sevil, Balogh Ágnes, Papp Zoltan, Brlecic Paige, Hegedüs Péter, Radovits Tamás, Karck Matthias, Merkely Béla, Veres Gábor
Dátum:	2022
ISSN:	1422-0067
Megjegyzések:	Demand for organs is increasing while the number of donors remains constant. Nevertheless, not all organs are utilized due to the limited time window for heart transplantation (HTX). Therefore, we aimed to evaluate whether an iron-chelator-supplemented Bretschneider solution could protect the graft in a clinically relevant canine model of HTX with prolonged ischemic storage. HTX was performed in foxhounds. The ischemic time was standardized to 4 h, 8 h, 12 h or 16 h, depending on the experimental group. Left ventricular (LV) and vascular function were measured. Additionally, the myocardial high energy phosphate and iron content and the in-vitro myocyte force were evaluated. Iron chelator supplementation proved superior at a routine preservation time of 4 h, as well as for prolonged times of 8 h and longer. The supplementation groups recovered quickly compared to their controls. The LV function was preserved and coronary blood flow increased. This was also confirmed by in vitro myocyte force and vasorelaxation experiments. Additionally, the biochemical results showed significantly higher adenosine triphosphate content in the supplementation groups. The iron chelator LK614 played an important role in this mechanism by reducing the chelatable iron content. This study shows that an iron-chelator-supplemented Bretschneider solution effectively prevents myocardial/endothelial damage during short- as well as long-term conservation.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	International Journal Of Molecular Sciences. - 23 : 13 (2022), p. 1-14. -
További szerzők:	Loganathan, Sivakkanan Korkmaz-Icöz, Sevil Balogh Ágnes (1984-) (kardiológus) Papp Zoltán (1965-) (kardiológus, élettanász) Brlecic, Paige Hegedüs Péter Radovits Tamás Karck, Matthias Merkely Béla (1965-) (orvos) Veres Gábor (orvos)
Pályázati támogatás:	K134939 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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