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001-es BibID:	BIBFORM121962
035-os BibID:	(Scopus)85197174794 (WoS)001256023400001
Első szerző:	Márk László (belgyógyász, kardiológus)
Cím:	The Evaluation of Lipid-Lowering Treatment in Patients with Acute Coronary Syndrome in a Hungarian Invasive Centre in 2015, 2017, and during the COVID-19 Pandemic - The Comparison of the Achieved LDL-Cholesterol Values Calculated with Friedewald and Martin-Hopkins Methods / Laszlo Mark, Péter Fülöp, Hajnalka Lőrincz, Győző Dani, Krisztina Fazekas Tajtiné, Attila Thury, György Paragh
Dátum:	2024
ISSN:	2077-0383
Megjegyzések:	Abstract: Background/Objectives: Patients with acute coronary syndrome (ACS) represent a vulnerable population. We aimed to investigate serum lipid levels of patients with ACS upon admission and during one year of the COVID-19 pandemic in a rural county hospital, and compared these findings with the data of patients with ACS in 2015 and 2017. The secondary aim of this paper was the comparison of the LDL-C values calculated with the Friedewald and Martin?Hopkins methods. Methods: A retrospective analysis of lipid-lowering data of patients treated with ACS in 2015, 2017 and in a COVID-19 year (1 April 2020?31 March 2021) was performed; the patient's numbers were 454, 513 and 531, respectively. Results: In the COVID-19 period one year after the index event, only 42% of the patients had lipid values available, while these ratios were 54% and 73% in 2017 and in 2015, respectively. Using the Friedewald formula, in the COVID-19 era the median of LDL cholesterol (LDL-F) was 1.64 (1.09?2.30) mmol/L at six months and 1.60 (1.19?2.27) mmol/L at one year, respectively. These values were 1.92 (1.33?2.27) mmol/L and 1.73 (1.36?2.43) mmol/L using the Martin?Hopkins method (LDL-MH). The LDL-F yielded significantly lower values (15% lower at six months, p = 0.044; and 8% lower at one year, p = 0.014). The LDL-F reached the previous target of 1.8 mmol/L during the COVID-19 pandemic 36% at one year vs. 48% in 2017, and 37% in 2015. The recent target LDL-C level of 1.4 mmol/L was achieved in 22% of cases in the COVID-19 pandemic, 16% in 2015 and 19% in 2017. Conclusions: A significantly lower proportion of patients with ACS had available lipid tests during the COVID-19 pandemic. Besides the lower number of available samples, the proportion of achieved 1.4 mmol/L LDL-C target lipids was stable. More rigorous outpatient care in the follow-up period may help to improve the quality of lipid lowering treatments and subsequent secondary cardiovascular prevention. If direct LDL-C determination is not available, we prefer the LDL calculation with the Martin?Hopkins method.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk acute coronary syndrome COVID-19 pandemic LDL-cholesterol Friedewald formula Martin-Hopkins method
Megjelenés:	Journal of Clinical Medicine. - 13 : 12 (2024), p. 1-12. -
További szerzők:	Fülöp Péter (1974-) (belgyógyász, endokrinológus, lipidológus) Lőrincz Hajnalka (1986-) (biológus) Dani Győző Tajtiné Fazekas Krisztina Thury Attila Paragh György (1953-) (belgyógyász)
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