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001-es BibID:	BIBFORM040672
035-os BibID:	PMID:16331753
Első szerző:	Zsilák Szilvia
Cím:	HLA-DR genotypes in familial rheumatoid arthritis : increased frequency of protective and neutral alleles in a multicase family / Szilvia Zsilák, János Gál, László Hodinka, Katalin Rajczy, Attila Balog, Sándor Sipka, Sándor Baráth, Anikó Kapitány, Erika Zilahi, Zoltán Szekanecz
Dátum:	2005
Megjegyzések:	We describe a unique family where each of the 5 siblings in the second generation has rheumatoid arthritis (RA). Two other members of the family have RA and systemic lupus erythematosus (SLE), respectively. No members of previous generations in the family had documented inflammatory arthritis. Due to the suspected genetic predisposition, HLA-DR genotypes were determined in the affected siblings and their parents, children, and grandchildren. We investigated the possible role of various HLA-DR alleles in the evolution of RA in this multicase family. METHODS: HLA-DRB1* alleles were determined by polymerase chain reaction using the sequence-specific primer-Olerup method. RESULTS: The most common alleles in the 6 persons with RA were HLA-DRB107 and DRB115, which are known to be protective and neutral in RA. No patient or family member carried any HLA-DR4 alleles. CONCLUSION: HLA-DRB107 and DRB115 alleles are thought to be protective or neutral in RA. However, the majority of RA patients in the family and nearly half of all family members carried these alleles, suggesting a role of these genotypes in susceptibility to RA. No RA patient in this family carried HLA-DR4 alleles. Thus, in our rare family with 6 RA cases, an unexpected genetic background may be involved in the increased susceptibility to inflammatory arthritis.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Adult Arthritis, Rheumatoid Female Gene Frequency Genetic Predisposition to Disease Genotype HLA-DR Antigens Humans Lupus Erythematosus, Systemic Male egyetemen (Magyarországon) készült közlemény
Megjelenés:	The Journal of Rheumatology. - 32 : 12 (2005), p. 2299-2302. -
További szerzők:	Gál János Hodinka László Rajczy Katalin Balog Attila Sipka Sándor (1945-) (laboratóriumi szakorvos) Baráth Sándor (1977-) (biológus) Kapitány Anikó (1979-) (molekuláris biológus) Zilahi Erika (1964-) (molekuláris biológus) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
Internet cím:	Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat
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