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001-es BibID:	BIBFORM051530
Első szerző:	Csillag Anikó (immunológus, biológus, angol-magyar szakfordító)
Cím:	Exposure to inhomogeneous static magnetic field beneficially affects allergic inflammation in a murine model / Anikó Csillag, Brahma V. Kumar, Krisztina Szabó, Mária Szilasi, Zsuzsa Papp, Magdolna E. Szilasi, Kitti Pázmándi, István Boldogh, Éva Rajnavölgyi, Attila Bácsi, János F. László
Dátum:	2014
ISSN:	1742-5689
Megjegyzések:	Previous observations suggest that static magnetic field (SMF)-exposure acts on living organisms partly through reactive oxygen species (ROS) reactions. In this study, we aimed to define the impact of SMF-exposure on ragweed pollen extract (RWPE)-induced allergic inflammation closely associated with oxidative stress. Inhomogeneous SMF was generated with an apparatus validated previously providing a peak-to-peak magnetic induction of the dominant SMF component 389 mT by 39 T m-1 lateral gradient in the in vivo and in vitro experiments, and 192 mT by 19 T m-1 in the human study at the 3 mm target distance. Effects of SMF-exposure were studied in a murine model of allergic inflammation and also in human provoked skin allergy.We found that even a single 30-min exposure of mice to SMF immediately following intranasal RWPE challenge significantly lowered the increase in the total antioxidant capacity of the airways and decreased allergic inflammation. Repeated (on 3 consecutive days) or prolonged (60 min) exposure to SMF after RWPE challenge decreased the severity of allergic responses more efficiently than a single 30-min treatment. SMF-exposure did not alter ROS production by RWPE under cell-free conditions, while diminished RWPEinduced increase in the ROS levels in A549 epithelial cells. Results of the human skin prick tests indicated that SMF-exposure had no significant direct effect on provoked mast cell degranulation. The observed beneficial effects of SMF are likely owing to the mobilization of cellular ROS-eliminating mechanisms rather than direct modulation of ROS production by pollen NAD(P)H oxidases.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban allergic inflammation oxidative stress pollen static magnetic field Doktori iskola
Megjelenés:	Journal of The Royal Society Interface. - 11 : 95 (2014), p. 20140097-20140097. -
További szerzők:	Kumar, Brahma V. Szabó Krisztina (1987-) (Molekuláris biológus) Szilasi Mária (1953-) (tüdőgyógyász, klinikai immunológus, allergológus, belgyógyász) Papp Zsuzsa Szilasi Magdolna Emma (1983-) (pulmonológus) Pázmándi Kitti Linda (1984-) (molekuláris biológus, immunológus) Boldogh István Rajnavölgyi Éva (1950-) (immunológus) Bácsi Attila (1967-) (immunológus) László F. János (1956-) (fizikus)
Pályázati támogatás:	NK 101538 OTKA K 73347 OTKA K 109595 OTKA 4.2.4.A/2-11-1-2012-001 TÁMOP TÁMOP-4.2.2/B-10/1-2010-0024 TÁMOP Molekuláris Sejt- és Immunbiológiai Doktori Iskola 4.2.2.A-11/1/KONV-2012-0023 TÁMOP
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