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001-es BibID:BIBFORM042086
Első szerző:Gomez Izabella (orvos)
Cím:In vivo calcium and phosphate iontophoresis on osteoporotic rat tibia. A new method for the topical treatment of osteoporosis / Gomez Izabella, Pap Lajos, Szabó Andrea, Boda Krisztina, Szekanecz Zoltán
Dátum:2012
Megjegyzések:Background: In the management of osteoporosis in addition to pharmaceutical therapy and diet, physiotherapy may also be included. Our research group developed a novel three-electrode iontophoretic apparatus involving the use of calcium- and phosphate-donating lattice suitable for local ion delivery into the bones. We performed in vivo studies on rats in order to compare the effects and efficacy of electrotherapy with that of systemic hormone replacement therapy.Materials and methods: Five months after the operation tibias of Sham and ovarectomized (OVX) Sprague-Dawley female rats were subjected to serial local iontophoretic treatment(IOP). Other OVX rats received systemic subcutaneous 17-beta-oestradiol therapy (E2,100ug/kg/day for 13 weeks) or were also treated with the combination of IOP and E2. Changes in bone density were detected for 90 days after IOP. At the end of the experiments, biomechanical studies were performed together with elemental analysis assessing the calcium and phosphate concentrations.Results: Serial iontophoretic treatment resulted in a longlasting increase in bone density in both the Sham and OVX animals. Similar changes could be detected after E2 monotherapy, further enhancement could be observed applyingE2 + IOP. The above improvement was also evident regardingthe biomechanical features of the tibias as reduced calcium and phosphate content of the bones caused by OVX could be reversed by IOP or E2 monotherapy, as well as combination therapy.Conclusions: Iontophoresis using calcium- and phosphate donating microparticles further enhances the efficacy of estrogen therapy by increasing bone density, restoring the calcium and phosphate balance and the biomechanical properties of the bone.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
Megjelenés:European Journal of Clinical Investigation. - 42 : Suppl.1 (2012), p. 66-67. -
További szerzők:Pap Lajos (1929-) (vegyész, analitikus) Szabó Andrea Boda Krisztina Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
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2.

001-es BibID:BIBFORM041933
Első szerző:Gomez Izabella (orvos)
Cím:In Vivo Calcium and Phosphate Iontophoresis for the Topical Treatment of Osteoporosis / Gomez, I., Szabó, A., Pap L. Jr., Pap, L., Szekanecz, Z.
Dátum:2011
ISSN:0003-4967
Megjegyzések:Background: We have recently developed a novel three-electrode iontophoretic apparatus involving the use of calcium- and phosphate-donating lattices suitable for local ion delivery into the bones. Here we performed in vivo studies on rats in order to compare the effects and efficacy of local electrotherapy with that of systemic hormone replacement therapy with respect to bone density and mineral content and biomechanical properties of osteoporotic bones.Methods: Three months old Sprague-Dawley rats were either ovariectomized (OVX) or sham-operated (Sham). Five months later, tibias ofSham and OVX animals were subjected to serial local iontophoretic treatments (IOP). Other OVX rats received systemic subcutaneous 17?-estradiol therapy (E2, 100 ?g/kg/week for 13 weeks) or were also treated with the combination of IOP and E2. Changes in bone density (as measured by quantitative ultrasound densitometry, QUS) were detected for 90 days after IOP. At the end of the experiments, biomechanical studies were performed together with elemental analysis assessing the calcium and phosphate concentrations.Results: Osteopenia developed 21 weeks after OVX in the proximal tibial regions. Serial iontophoretic treatment resulted in a long lasting increase in bone density in both the Sham and OVX animals. Similar changes in QUS data could be detected after E2 monotherapy and further enhancement could be observed applying E2+IOP. The above improvement was also evident regarding the biomechanical features of the tibias (Fmax and stiffness) as reduced calcium and phosphate content of the bones caused by OVX could be reversed by both serial IOP and E2 monotherapy, as well as combination therapy.Conclusions: Local IOP using calcium- and phosphate-donating microparticles further enhances the efficacy of estrogen therapy by steadily increasing bone density, restoring the calcium and phosphate balance and improving the biomechanical properties of the bone.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
Megjelenés:Annals Of The Rheumatic Diseases. - 70 : Suppl.3 (2011), p. 360. -
További szerzők:Szabó Andrea Pap Lajos (jr.) Pap Lajos (1929-) (vegyész, analitikus) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
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3.

001-es BibID:BIBFORM041924
Első szerző:Gomez Izabella (orvos)
Cím:In Vivo Calcium and Phosphate Iontophoresis for the Topical Treatment of Osteoporosis / Gomez I., Szabó A., Pap L. Jr., Pap L., Boda K., Szekanecz Z.
Dátum:2012
ISSN:0031-9023
Megjegyzések:Background In addition to systemic treatment, osteoporosis may be treated topically by incorporating calcium and phosphate into the bone.Objective This article describes the use of a recently developed, novel iontophoretic apparatus suitable for local ion delivery into bones. In this study, in vivo experiments were performed to compare the effects of local electrotherapy and those of systemic hormone replacement on bone.Design In this study, local iontophoresis was carried out in ovariectomized and control rats. Bone density, biomechanical, and elemental studies were performed.Methods Forty 12-week-old Sprague-Dawley rats received an ovariectomy (OVX) or were sham-operated (sham). Twenty-one weeks later, tibias of subgroups of sham-operated and OVX animals were subjected to serial local iontophoresis (IOP) treatments, received systemic subcutaneous 17?-estradiol (E2), or were treated with the combination of IOP and E2. Changes in bone density were detected by quantitative ultrasound densitometry and expressed as amplitude-dependent speed of sound (AD-SoS). Biomechanical studies and elemental analysis were performed at the end of the experiments.Results Osteopenia developed 21 weeks after OVX in the proximal tibial regions; the mean difference estimate (95% confidence intervals) of AD-SoS values between the sham-operated and OVX animals was 188.7 (140.4?237.1). Serial iontophoretic treatment resulted in an increase in bone density in both sham-operated and OVX animals (sham+IOP versus sham: 121.4 [73.01?169.7]; OVX+IOP versus OVX: 241.6 [193.2?289.9]). Similar changes in AD-SoS were detected after 17?-estradiol (E2) treatment; however, even greater changes occurred after OVX+E2+IOP versus OVX+E2 (123.4 [75.1?171.8]). Similar improvements also were evident regarding the biomechanical features of the tibias.Limitations A limitation of this study was the relatively small number of rats.Conclusions The efficacy of local IOP using calcium- and phosphate-donating microparticles is comparable to that of estrogen therapy as evidenced by steadily increasing bone density, restoration of the calcium and phosphate balance, and improvement in the biomechanical properties of the bone.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Physical Therapy. - 92 : 2 (2012), p. 289-297. -
További szerzők:Szabó Andrea Pap Lajos (jr.) Pap Lajos (1929-) (vegyész, analitikus) Boda Katalin Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
Pályázati támogatás:T 048541
OTKA
TÁMOP-4.2.2-08/1-2008-0013
TÁMOP
TÁMOP-4.2.1/B-09/1/KONV-2010-0005
TÁMOP
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4.

001-es BibID:BIBFORM035743
Első szerző:Gomez Izabella (orvos)
Cím:Calcium and phosphate delivery into osteoporotic rat tibia by a new iontophoretic treatment in vivo / Gomez I., Pap L., Szabó A., Boros M., Szekanecz Z.
Dátum:2008
Tárgyszavak:Természettudományok Kémiai tudományok idézhető absztrakt
Megjelenés:Annals of the Rheumatic Diseases. - 67 : Suppl.1. (2008), p. A50-A51. -
További szerzők:Pap Lajos (1929-) (vegyész, analitikus) Szabó Andrea Boros Mihály (Szeged) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
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5.

001-es BibID:BIBFORM041922
Első szerző:Pap Lajos (vegyész, analitikus)
Cím:Development of natural calcium- and phosphate-donating microparticles and a new iontophoretic apparatus for the topical treatment of local osteoporosis. Preliminary in vitro and in vivo studies / Pap Lajos, Gomez Izabella, Pap Lajos Jr., Szabó Andrea, Szekanecz Zoltán
Dátum:2010
ISSN:1297-319X
Megjegyzések:We wished to develop a new iontophoretic device suitable for the treatment of local bone loss such as after fractures or in osteodystrophy. METHODS:The new iontophoretic apparatus consists of two parts. The first part consists of two natural-based, chemically modified particles as potential medicines, while the other part is a 3-electrode electrophoretic device based on a new principle. This device 'knocks out' Ca?(+) and PO? ?? ions from the particles with its impulse-like positive and negative charges transmitted through its electrodes placed on the skin. The current and the voltage of the electrodes can be adjusted separately in both leads. Subsequently, these 'knocked out' ions are channelled into the porotic bones with the help of the 3rd-reference-electrode.RESULTS:In our preliminary in vitro studies, we used porcine tissues to test their calcium and phosphate content after iontophoresis; with or without using molecules. This preliminary analysis revealed that both calcium and phosphate ions became incorporated into the bone. Some in vivo data are also presented. Iontophoretic treatment increased speed of sound (SOS) as determined by ultrasonography in ovariectomized rats.CONCLUSION:Our results suggest that topical iontophoresis may be suitable to treat local osteoporosis or bone defects.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Joint Bone Spine. - 77 : 5 (2010), p. 426-431. -
További szerzők:Gomez Izabella (1981-) (orvos) Pap Lajos (jr.) Szabó Andrea Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
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6.

001-es BibID:BIBFORM035744
Első szerző:Pap Lajos (vegyész, analitikus)
Cím:Natural drugs and use thereof as well as method of treatment and apparatus for healing osteoporosis / Pap Lajos, Gomez Izabella, Szántó Andrea, Szabó Andrea, Boros Mihály, Emri Józsefné
Dátum:2006
Megjelenés:Geneve : World Intellectual Property Organization, 2006
Terjedelem:14 p.
Tárgyszavak:Természettudományok Kémiai tudományok szabadalom
További szerzők:Gomez Izabella (1981-) (orvos) Szántó Andrea Zsuzsanna Szabó Andrea Boros Mihály (Szeged) Emri Józsefné
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7.

001-es BibID:BIBFORM035742
Első szerző:Pap Lajos (vegyész, analitikus)
Cím:Development of natural calcium- and phosphate-donating molecules and a new iontophoretic device for the topical treatment of osteoporosis. Preliminary in vitro and in vivo studies / Lajos Pap, Izabella Gomez, Lajos Pap Jr., Andrea Szabó, Zoltán Szekanecz
Dátum:2009
Tárgyszavak:Természettudományok Kémiai tudományok előadáskivonat
Megjelenés:Arthritis and Rheumatism. - p. 223
További szerzők:Gomez Izabella (1981-) (orvos) Pap Lajos (jr.) Szabó Andrea Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
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