Találati lista | Tudóstér

001-es BibID:	BIBFORM083439
Első szerző:	Garai Dorottya (biológus)
Cím:	Measurements for Sulfide-Mediated Inhibition of Myeloperoxidase Activity / Garai D., Pálinkás Z., Balla J., Kettle A. J., Nagy P.
Dátum:	2019
ISSN:	1064-3745 1940-6029
Megjegyzések:	Oxidative stress-alleviating and inflammation-mediatory functions of hydrogen sulfide were reported to be key features of its biological actions. However, the underlying molecular mechanisms of these biological observations are not fully understood. In conditions where sulfide was proposed to be protective against oxidative stress- or inflammation-induced tissue damage (e.g., reperfusion injury, atherosclerosis, vascular inflammation), the reactive oxidant-producing function of a key neutrophil enzyme, myeloperoxidase, was reported to be a protagonist on the detrimental side. We recently described favorable interactions between sulfide and myeloperoxidase and proposed that the potent inhibition of myeloperoxidase activities could contribute to sulfide's beneficial functions in a number of cardiovascular pathologies. Our chapter is dedicated to aid future studies and drug development endeavors in this area by providing methodological guidance on how to assess the inhibitory potential of sulfide on myeloperoxidase enzymatic activities in isolated protein systems, in neutrophil homogenates, and in live neutrophil preparations.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Myeloperoxidase Hydrogen sulfide Peroxidase activity Halogenation activity Neutrophil function
Megjelenés:	Methods in Molecular Biology. - 2007 (2019), p. 179-203. -
További szerzők:	Pálinkás Zoltán (1984-) (vegyész) Balla József (1959-) (belgyógyász, nephrológus) Kettle, Anthony J. Nagy Péter (1976-) (vegyész)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00043 GINOP K 112333 OTKA K 109843 OTKA KH17_126766 OTKA K18_129286 OTKA MTA-DE MTA Vascularis Biológia, Thrombosis-Haemostasis Kutatócsoport
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: