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001-es BibID:	BIBFORM035769
Első szerző:	Buzás Edit
Cím:	Effect of pregnancy on proteoglycan-induced progressive polyarthritis in BALB/c mice : remission of disease activity / Búzás E. I., Holló K., Rubliczky M., Garzó P., Nyirkos T., Glant T. T.
Dátum:	1993
ISSN:	0009-9104
Megjegyzések:	Proteoglycan-induced arthritis is a murine autoimmune model displaying many similarities to human rheumatoid arthritis and ankylosing spondylitis, as has been documented by clinical, immunological and histopathological studies. Since the onset of arthritis correlates with the serum antibody level to mouse cartilage proteoglycan (PG), it is believed that these autoreactive antibodies may play crucial roles in the pathological mechanisms of PG-induced arthritis. We have found that fertility in these PG-induced arthritic mice had been reduced but, unlike collagen-induced arthritis, had not been completely lost. Moreover, pregnancy had a beneficial effect upon the clinical symptoms with very little or no influence on serum antibody levels. Although fertility was retained and arthritic mothers delivered healthy offspring, the birth frequency was significantly less than in non-arthritic age-matched controls. Furthermore, the presence of anti-PG autoantibodies (predominantly IgG1 subclass) transmitted from arthritic mothers to infants transplacentally and by milk during the lactation period did not render these offspring either resistant or more sensitive to subsequent induction of arthritis. Subsequent immunization of infants with 'arthritogenic' PG revealed an unaltered susceptibility to arthritis induction.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Clinical And Experimental Immunology. - 94 : 2 (1993), p. 252-260. -
További szerzők:	Holló Krisztina (1967-) (vegyész) Rubliczky M. Garzó P. Nyirkos T. Glant Tibor T.
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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