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001-es BibID:BIBFORM091921
035-os BibID:(cikkazonosító)1253 (WoS)000628419600001 (Scopus)85102544108
Első szerző:Szabó Zsuzsanna (biológus, biológia-kémia szakos középiskolai tanár)
Cím:Expression of Luteinizing Hormone-Releasing Hormone (LHRH) and Type-I LHRH Receptor in Transitional Cell Carcinoma Type of Human Bladder Cancer / Zsuzsanna Szabó, Balázs Dezső, Klára Fodor, Krisztián Szegedi, Tibor Flaskó, Erzsébet Szabó, Gábor Oláh, Éva Sipos, Nikoletta Dobos, János Gardi, Andrew V. Schally, Gábor Halmos
Dátum:2021
Megjegyzések:Bladder cancer (BC) is the tenth most frequently detected cancer in both sexes. Type-I luteinizing hormonereleasing hormone (LHRH) receptor (LHRH?R?I) is expressed not only in the pituitary, but also in several types of cancer disease. There are few data about LHRH?R?I expression in human BC. This study aimed to investigate the expression of LHRH and LHRH?R?I in the transitional cell carcinoma (TCC) type of human BC. RNA was extracted from 24 human bladder tumor specimens and three BC cell lines. RT?PCR was performed to detect mRNA for LHRH and LHRHR? I. The protein of LHRH?R?I was further studied by immunohistochemistry (IHC), ligand competition assay, and Western Blot. PCR products of LHRH were found in 19 of 24 (79%) specimens and mRNA of LHRH?R?I was detected in 20 of 24 specimens (83%). Positive immunostaining for LHRHR? I with different expression intensity was found in all samples examined, showing negative correlation with TCC grade. Radioligand binding studies also showed the presence of specific LHRH?RI and high affinity binding of LHRH analogs. The high incidence of LHRH-R in BC suggests that it could serve as a molecular target for therapy of human BC with cytotoxic LHRH analogs or modern powerful antagonistic analogs of LHRH.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Molecules. - 26 : 5 (2021), p. 1-14. -
További szerzők:Dezső Balázs (1951-) (pathológus) Molnár-Fodor Klára (1989-) (biotechnológus) Szegedi Krisztián (1981-) (orvos) Flaskó Tibor (1960-) (urológus) Szabó Erzsébet (1973-) (molekuláris biológus) Oláh Gábor (1987-) (gyógyszerész) Sipos Éva (1989-) (gyógyszerész) Dobos Nikoletta (1981-) (biológus) Gardi János Schally, Andrew Victor Halmos Gábor (1962-) (gyógyszerész, receptorfarmakológus, experimentális onkológus)
Pályázati támogatás:GINOP-2.3.2-15-2016-00043
GINOP
TKP2020?IKA?04
Egyéb
Internet cím:Szerző által megadott URL
DOI
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2.

001-es BibID:BIBFORM048907
035-os BibID:(PMID)24077773
Első szerző:Treszl Andrea (molekuláris biológus)
Cím:Substantial expression of luteinizing hormone-releasing hormone (LHRH) receptor type I in human uveal melanoma / Andrea Treszl, Zita Steiber, Andrew V. Schally, Norman L. Block, Balazs Dezso, Gabor Olah, Bernadett Rozsa, Klara Fodor, Armin Buglyo, Janos Gardi, Andras Berta, Gabor Halmos
Dátum:2013
ISSN:1949-2553
Megjegyzések:Uveal melanoma is the most common primary intraocular malignancy in adults, with a very high mortality rate due to frequent liver metastases. Consequently, the therapy of uveal melanoma remains a major clinical challenge and new treatment approaches are needed. For improving diagnosis and designing a rational and effective therapy, it is essential to elucidate molecular characteristics of this malignancy. The aim of this study therefore was to evaluate as a potential therapeutic target the expression of luteinizing hormone-releasing hormone (LHRH) receptor in human uveal melanoma. The expression of LHRH ligand and LHRH receptor transcript forms was studied in 39 human uveal melanoma specimens by RT-PCR using gene specific primers. The binding charachteristics of receptors for LHRH on 10 samples were determined by ligand competition assays. The presence of LHRH receptor protein was further evaluated by immunohistochemistry. The expression of mRNA for type I LHRH receptor was detected in 18 of 39 (46%) of tissue specimens. mRNA for LHRH-I ligand could be detected in 27 of 39 (69%) of the samples. Seven of 10 samples investigated showed high affinity LHRH-I receptors. The specific presence of full length LHRH receptor protein was further confirmed by immunohistochemistry. A high percentage of uveal melanomas express mRNA and protein for type-I LHRH receptors. Our results support the merit of further investigation of LHRH receptors in human ophthalmological tumors. Since diverse analogs of LHRH are in clinical trials or are already used for the treatment of various cancers, theseanalogs could be considered for the LHRH receptor-based treatment of uveal melanoma.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
uveal melanoma
luteinizing hormone-releasing hormone (LHRH) receptor
Megjelenés:Oncotarget. - 4 : 10 (2013), p. 1721-1728. -
További szerzők:Steiber Zita (1977-) (orvos, szemész) Schally, Andrew Victor Block, Norman L. Dezső Balázs (1951-) (pathológus) Oláh Gábor (1987-) (gyógyszerész) Rózsa Bernadett (1981-) (molekuláris biológus) Molnár-Fodor Klára (1989-) (biotechnológus) Buglyó Armin Gardi János Berta András (1955-) (szemész, gyermekszemész) Halmos Gábor (1962-) (gyógyszerész, receptorfarmakológus, experimentális onkológus)
Pályázati támogatás:TÁMOP-4.2.2.A-11/1/KONV-2012-0025
TÁMOP
K81596
OTKA
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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