Találati lista | Tudóstér

001-es BibID:	BIBFORM016595
Első szerző:	Varga Tamás (biológus)
Cím:	PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation / Tamas Varga, Zsolt Czimmerer, Laszlo Nagy
Dátum:	2011
ISSN:	0925-4439
Megjegyzések:	Cells are constantly exposed to a large variety of lipids. Traditionally, these molecules were thought to serve as simple energy storing molecules. More recently it has been realized that they can also initiate and regulate signaling events that will decisively influence development, cellular differentiation, metabolism and related functions through the regulation of gene expression. Multicellular organisms dedicate a large family of nuclear receptors to these tasks. These proteins combine the defining features of both transcription factors and receptor molecules, and therefore have the unique ability of being able to bind lipid signaling molecules and transduce the appropriate signals derived from lipid environment to the level of gene expression. Intriguingly, the members of a subfamily of the nuclear receptors, the peroxisome proliferator-activated receptors (PPARs) are able to sense and interpret fatty acid signals derived from dietary lipids, pathogenic lipoproteins or essential fatty acid metabolites. Not surprisingly, PPARs were found to be key regulators of lipid and carbohydrate metabolism. Unexpectedly, later studies revealed that PPARs are also able to modulate inflammatory responses. Here we summarize our understanding on how these transcription factors/receptors connect lipid metabolism to inflammation and some of the novel regulatory mechanisms by which they contribute to homeostasis and certain pathological conditions. This article is part of a Special Issue entitled: Translating nuclear receptors from health to disease.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban PPAR Inflammation Lipid metabolism Transcriptional regulation
Megjelenés:	Biochimica et Biophysica Acta (BBA). Molecular Basis of Disease. - 1812 : 8 (2011), p. 1007-1022. -
További szerzők:	Czimmerer Zsolt (1981-) (molekuláris biológus) Nagy László (1966-) (molekuláris sejtbiológus, biokémikus)
Internet cím:	DOI Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: