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001-es BibID:BIBFORM115442
035-os BibID:(WoS)000469480000024 (Scopus)85053303109
Első szerző:Gao, Liang
Cím:Asymptomatic focal calcium pyrophosphate crystal deposition within partially failed repair tissue after matrix-assisted autologous chondrocyte implantation / Liang Gao, Tamás Oláh, Magali Cucchiarini, Henning Madry
Dátum:2018
ISSN:0942-2056
Megjegyzések:Possible failures of autologous chondrocyte implantation (ACI), a cell-based technique for articular cartilage repair, are not always clinically apparent and the underlying mechanisms largely remain unknown. This case report presents the first scenario in the literature highlighting an association of a medium-term partial failure of an advanced ACI procedure (matrix-assisted ACI) in the knee with focal asymptomatic calcium pyrophosphate deposition disease, a common inflammatory pyrophosphate arthropathy. The specific presence of CPPDs, resulting from increased biomechanical stresses in the repair tissue?cartilage and repair tissue?subchondral bone integration sites, together with the absence of cartilage regeneration was identified and possibly contributed to the partial failure.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Matrix-assisted autologous chondrocyte implantation
Calcium pyrophosphate deposition disease
Asymptomatic failure
Mid-term outcome
Knee
Megjelenés:Knee Surgery Sports Traumatology Arthroscopy. - 27 : 6 (2018), p. 1939-1942. -
További szerzők:Oláh Tamás (1983-) (élettanász) Cucchiarini, Magali Madry, Henning
Internet cím:Szerző által megadott URL
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001-es BibID:BIBFORM118408
035-os BibID:(WoS)001070595600001 (Scopus)85172002316
Első szerző:Oláh Tamás (élettanász)
Cím:Subchondral bone remodeling patterns in larger animal models of meniscal injuries inducing knee osteoarthritis - a systematic review / Tamás Oláh, Magali Cucchiarini, Henning Madry
Dátum:2023
ISSN:0942-2056
Megjegyzések:Purpose: Elucidating subchondral bone remodeling in preclinical models of traumatic meniscus injury may address clinically relevant questions about determinants of knee osteoarthritis (OA). Methods: Studies on subchondral bone remodeling in larger animal models applying meniscal injuries as standardizing entity were systematically analyzed. Of the identified 5367 papers reporting total or partial meniscectomy, meniscal transection or destabilization, 0.4% (in guinea pigs, rabbits, dogs, minipigs, sheep) remained eligible. Results: Only early or mid-term time points were available. Larger joint sizes allow reporting higher topographical details. The most frequently reported parameters were BV/TV (61%), BMD (41%), osteophytes (41%) and subchondral bone plate thickness (39%). Subchondral bone plate microstructure is not comprehensively, subarticular spongiosa microstructure is well characterized. The subarticular spongiosa is altered shortly before the subchondral bone plate. These early changes involve degradation of subarticular trabecular elements, reduction of their number, loss of bone volume and reduced mineralization. Soon thereafter, the previously normal subchondral bone plate becomes thicker. Its porosity first increases, then decreases. Conclusion: The specific human topographical pattern of a thinner subchondral bone plate in the region below both menisci is present solely in the larger species (partly in rabbits), but absent in rodents, an important fact to consider when designing animal studies examining subchondral consequences of meniscus damage. Large animal models are capable of providing high topographical detail, suggesting that they may represent suitable study systems reflecting the clinical complexities. For advanced OA, significant gaps of knowledge exist. Future investigations assessing the subchondral bone in a standardized fashion are warranted.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Meniscus
Meniscal tear
Subchondral bone
Animal model
Osteoarthritis
Systematic review
Megjelenés:Knee Surgery Sports Traumatology Arthroscopy. - 31 : 12 (2023), p. 5346-5364. -
További szerzők:Cucchiarini, Magali Madry, Henning
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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