CCL

Összesen 2 találat.
#/oldal:
Részletezés:
Rendezés:

1.

001-es BibID:BIBFORM114906
035-os BibID:(Scopus)85123905875 (WOS)000747294800006 (cikkazonosító)eabn0179
Első szerző:Oláh Tamás (élettanász)
Cím:Axial alignment is a critical regulator of knee osteoarthritis / Tamás Oláh, Jan Reinhard, Matthias W. Laschke, Lars K. H. Goebel, Frédéric Walter, Gertrud Schmitt, Susanne Speicher-Mentges, Michael D. Menger, Magali Cucchiarini, Dietrich Pape, Henning Madry
Dátum:2022
ISSN:1946-6234
Megjegyzések:Although osteoarthritis (OA), a leading cause of disability, has been associated with joint malalignment, scientific translational evidence for this link is lacking. In a clinical case study, we provide evidence of osteochondral recovery upon unloading symptomatic isolated medial tibiofemoral knee OA associated with varus malalignment. By mapping response correlations at high resolution, we identify spatially complex degenerative changes in cartilage after overloading in a clinically relevant ovine model. We further report that unloading diminishes OA cartilage degeneration and alterations of critical parameters of the subchondral bone plate in a similar topographic fashion. Last, therapeutic unloading shifted the articular cartilage and subchondral bone phenotype to normal and restored several physiological correlations disturbed in neutral and varus OA, suggesting a protective effect on the integrity of the entire osteochondral unit. Collectively, these findings identify modifiable trajectories with considerable translational potential to reduce the burden of human OA.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Science Translational Medicine. - 14 : 629 (2022), p. eabn0179. -
További szerzők:Reinhard, Jan Laschke, Matthias W. Goebel, Lars Walter, Frédéric Schmitt, Gertrud Speicher-Mentges, Susanne Menger, Michael D. Cucchiarini, Magali Pape, Dietrich Madry, Henning
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

2.

001-es BibID:BIBFORM114887
035-os BibID:(WOS)000806728200001 (Scopus)85131298379 (cikkazonosító)2201692
Első szerző:Oláh Tamás (élettanász)
Cím:Quantifying the Human Subchondral Trabecular Bone Microstructure in Osteoarthritis with Clinical CT / Tamás Oláh, Xiaoyu Cai, Liang Gao, Frédéric Walter, Dietrich Pape, Magali Cucchiarini, Henning Madry
Dátum:2022
ISSN:2198-3844
Megjegyzések:Osteoarthritis (OA) is characterized by critical alterations of the subchondral bone microstructure, besides the well-known cartilaginous changes. Clinical computed tomography (CT) detection of quantitative 3D microstructural subchondral bone parameters is applied to monitor changes of subchondral bone structure in different stages of human OA and is compared with micro-CT, the gold standard. Determination by clinical CT (287 ?m resolution) of key microstructural parameters in tibial plateaus with mild-to-moderate and severe OA reveals strong correlations to micro-CT (35 ?m), high inter- and intraobserver reliability, and small relative differences. In vivo, normal, mild-to-moderate, and severe OA are compared with clinical CT (331 ?m). All approaches detect characteristic expanded trabecular structure in severe OA and fundamental microstructural correlations with clinical OA stage. Multivariate analyses at various in vivo and ex vivo imaging resolutions always reliably separate mild-to-moderate from severe OA (except mild-to-moderate OA from normal), revealing a striking similarity between 287 ?m clinical and 35 ?m micro-CT. Thus, accurate structural measurements using clinical CT with a resolution near the trabecular dimensions are possible. Clinical CT offers an opportunity to quantitatively monitor subchondral bone microstructure in clinical and experimental settings as an advanced tool of investigating OA and other diseases affecting bone architecture.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
3D microstructure
computed tomography
microcomputed tomography
multislice computed tomography
osteoarthritis of knee
subchondral bone
Megjelenés:Advanced Science. - 9 : 23 (2022), p. 2201692. -
További szerzők:Cai, Xiaoyu Gao, Liang Walter, Frédéric Pape, Dietrich Cucchiarini, Magali Madry, Henning
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Rekordok letöltése1