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001-es BibID:BIBFORM049317
Első szerző:Ungvári Éva (molekuláris biológus)
Cím:Protective effects of meat from lambs on selenium nanoparticle supplemented diet in a mouse model of polycyclic aromatic hydrocarbon-induced immunotoxicity / Éva Ungvári, István Monori, Attila Megyeri, Zoltán Csiki, József Prokisch, Attila Sztrik, András Jávor, Ilona Benkő
Dátum:2014
ISSN:0278-6915
Megjegyzések:Increased environmental oxidative stress caused primarily by chemicals like polycyclic aromatic hydrocarbons, plays significant role in human diseases. A representative compound, 7,12-dimethylbenz(a)anthracene (DMBA), was used for modeling oxidative damages including the significant decrease of the antioxidant capacity of the blood. Selenium has antioxidant effects but with a narrow therapeutic window. In our current studies to avoid accidental overdose and toxicity selenium was given to meat-producing animals. The standard rodent diet of mice was replaced by meat from lambs either on standard or selenium-enriched diet. Selenium concentration of lamb meat was enhanced three times by nano-selenium administration and an increase in the antioxidant capacity of the blood of mice was measured after the indirect selenium supplementation. Protective effects were also observed against DMBA-induced immunotoxicity. Twice the amount of white blood cells and among them three times more phagocytes survived. Similarly, in their renewal system in bone marrow twice the amount of cells survived and regenerative capacity of granulopoiesis was four times higher than in control DMBA-damaged mice. Our findings suggest functional dietary benefits of lamb meat enriched with selenium by feeding lambs with nanoparticle selenium supplements.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
oxidative stress
polycyclic aromatic hydrocarbon
immunotoxicity
selenium
nanoparticles
Megjelenés:Food And Chemical Toxicology. - 64 (2014), p. 298-306. -
További szerzők:Monori István (1976-) (agrármérnök) Megyeri Attila (1968-) (orvos) Csiki Zoltán (1962-) (belgyógyász, allergológus, klinikai immunológus, reumatológus) Prokisch József (1966-) (vegyész) Sztrik Attila (1983-) (táplálkozástudomány) Jávor András (1952-) (agrármérnök) Benkő Ilona (1954-) (orvos, farmakológus)
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