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001-es BibID:	BIBFORM037732
Első szerző:	Padra János Tamás (biológus)
Cím:	Leptin triggers Ca2+ imbalance in monocytes of overweight subjects / János Padra, Ildikó Seres, Gabriella Fóris, György Paragh Jr., Gabriella Kónya, György Paragh
Dátum:	2012
ISSN:	0143-4179
Megjegyzések:	Obesity is a major risk factor in numerous diseases, in which elevated intracellular Ca(2+) plays a major role in increased adiposity. We examined the difference between Ca(2+) signals in monocytes of lean and overweight subjects and the relationship between leptin induced NADPH oxidase activation and intracellular calcium concentration [Ca(2+)](i) homeostasis. Our results are as follows: (1) The basal level of [Ca(2+)](i) in resting monocytes of overweight subjects (OW monocytes) was higher than that in control cells, whereas the leptin-induced peak of the Ca(2+) signal was lower and the return to basal level was delayed. (2) Ca(2+) signals were more pronounced in OW monocytes than in control cells. (3) Using different inhibitors of cellular signaling, we found that in control cells the Ca(2+) signals originated from intracellular pools, whereas in OW cells they were generated predominantly by Ca(2+)-influx from medium. Finally, we found correlation between leptin induced superoxide anion generation and Ca(2+) signals. The disturbed [Ca(2+)](i) homeostasis in OW monocytes was fully restored in the presence of fluvastatin. Statins have pleiotropic effects involving the inhibition of free radical generation that may account for its beneficial effect on elevated [Ca(2+)](i) and consequently on the pathomechanism of obesity.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Egészség- és Környezettudomány Leptin Obesity calcium Ca2+ signal monocyte fluvastatin
Megjelenés:	Neuropeptides 46 (2012), p. 203-209. -
További szerzők:	Seres Ildikó (1954-) (biokémikus) Fóris Gabriella (1937-) (belgyógyász) Paragh György Jr. (1978-) (bőrgyógyász) Kónya Gabriella (1982-) (molekuláris biológus) Paragh György (1953-) (belgyógyász)
Pályázati támogatás:	TÁMOP-4.2.1/B-09/1/KONV-2010-0007 TÁMOP Gyulladásos és egyéb proatherogén tényezők vizsgálata a lipidanyagcsere zavarával járó kórállapotokban TÁMOP-4.2.2/B-10/1-2010-0024 TÁMOP
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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