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001-es BibID:BIBFORM049039
035-os BibID:(Scopus)84890086941 (PMID)24314997 (WoS)000328304700070
Első szerző:Lőcsey Lajos (belgyógyász, nephrológus)
Cím:Relationship Between Serum Paraoxonase and Homocysteine Thiolactonase Activity, Adipokines, and Asymmetric Dimethyl Arginine Concentrations in Renal Transplant Patients / L. Locsey, I. Seres, F. Sztanek, M. Harangi, J. Padra, D. Kovacs, R. Fedor, L. Asztalos, G. Paragh
Dátum:2013
ISSN:0041-1345
Megjegyzések:Paraoxonase lactonase activity protects against homocysteinylation; therefore, it can be a potential contributing factor to prevent atherosclerosis. We aimed to determine paraoxonase and HTLase activities and to clarify the relationship between HTLase activity and some cardiovascular risk factors, such as homocysteine, cystatin C asymmetric dimethylarginine (ADMA), and adipokines both in hemo dialyzed and transplanted patients. Among 114 hemodialyzed, 80 transplanted and 64 healthy control subjects, we investigated body mass index (BMI) as well as fasting serum contents of urea, uric acid, creatinine, cystatin C, homocysteine, glucose, lipids, total protein and albumin. Serum paraoxonase (PON 1) and HTLase activities were measured spectrophotometrically. ADMA, ADPN adiponectin, leptin (LEP) levels was determined with a sandwich enzyme-linked immunosorbent assay method. Dyslipidemic patients showed hypercholesterolemia, and high low-density lipoprotein (LDL); parallel with improved renal function, they displayed decreased cystatin C and homocysteine levels (P < .001). There was a significant negative correlation between PON 1 activity and cystatin C and homocysteine concentrations (P < .05). Obese patients revealed significantly higher LDL (P < .05) and leptin concentrations (P < .01). There was a significant positive correlation between PON 1 activity and adiponectin levels (P = .0276). Both dialyzed and transplanted patients displayed significantly lower HTLase activities compared to the control group (P < .001), particularly lower HTLase and PON 1 activities in dialyzed subjects compared with the transplanted group (P < .05). HTLase activity showed significant negative correlations with ADMA levels among the whole study population (P < .001), whereas positive associations were noted between PON 1 and HTLase activities (P < .001). HTLase activity may be a new predictor of cardiovascular risk in renal failure although it is modulated by other risk factors.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Transplantation Proceedings. - 45 : 10 (2013), p. 3685-3687. -
További szerzők:Seres Ildikó (1954-) (biokémikus) Sztanek Ferenc (1982-) (orvos) Harangi Mariann (1974-) (belgyógyász, endokrinológus) Padra János Tamás (1984-) (biológus) Kovács Dávid Ágoston (1982-) (sebész) Fedor Roland (1975-) (sebész) Asztalos László (1951-) (sebész) Paragh György (1953-) (belgyógyász)
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001-es BibID:BIBFORM042013
Első szerző:Sztanek Ferenc (orvos)
Cím:Decreased human paraoxonase-1 (PON1) lactonase activity in hemodialyzed and renal transplanted patients. A novel cardiovascular biomarker in end-stage renal disease / Ferenc Sztanek, Ildikó Seres, Mariann Harangi, Lajos Lőcsey, János Padra, György Paragh Jr., László Asztalos, György Paragh
Dátum:2012
ISSN:0931-0509
Megjegyzések:BACKGROUND:Human paraoxonase-1 (PON1) has also been described as a lactonase. Decreased PON1 lactonase activity was found to be a predictor of cardiovascular disease. Homocysteine thiolactonase activity may prevent proteins from homocysteinylation and is thought to be a protective factor against the progression of atherosclerosis. Previous studies have demonstrated decreased PON1 paraoxonase activity in hemodialyzed (HD) and renal transplant (TRX) patients; however, lactonase activity has not been investigated. We aimed to determine the paraoxonase and lactonase activities and to clarify the relationship between lactonase activity and a set of cardiovascular risk factors, such as homocysteine, cystatin C and asymmetric dimethylarginine (ADMA) levels, in HD and TRX patients and in healthy controls.METHODS:One hundred and eight HD and 78 TRX patients and 63 healthy controls were involved in the study. Paraoxonase and lactonase activities (paraoxon and gamma-thiobutyrolactone as substrates) were measured spectrophotometrically. ADMA level was determined with sandwich enzyme-linked immunosorbent assay.RESULTS:Both HD and TRX patients had significantly lower lactonase activities compared to the control group (P<0.05). Significantly lower paraoxonase activities were found in HD patients compared to the TRX group (P<0.05). Significant negative correlation was found between lactonase activity and ADMA level in the whole study population (P<0.001), while paraoxonase and lactonase activities showed significant positive correlation (P<0.001). Multiple regression analysis identified paraoxonase activity and homocysteine level as independent predictors of lactonase activity.CONCLUSION:Lactonase activity is a potential new predictor of cardiovascular risk in renal failure. Measurement of lactonase activity is recommended in future studies on HD and TRX patients.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
chronic renal failure
lactonase
paraoxonase
renal transplantation
asymmetric dimethylarginine
Megjelenés:Nephrology Dialysis Transplantation. - 27 : 7 (2012), p. 2866-2872. -
További szerzők:Seres Ildikó (1954-) (biokémikus) Harangi Mariann (1974-) (belgyógyász, endokrinológus) Lőcsey Lajos (1946-2013) (belgyógyász, nephrológus) Padra János Tamás (1984-) (biológus) Paragh György Jr. (1978-) (bőrgyógyász) Asztalos László (1951-) (sebész) Paragh György (1953-) (belgyógyász)
Pályázati támogatás:TÁMOP-4.2.1/B-09/1/KONV-2010-0007
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Gyulladásos és egyéb proatherogén tényezők vizsgálata a lipidanyagcsere zavarával járó kórállapotokban
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