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001-es BibID:	BIBFORM073568
Első szerző:	Somodi Sándor (belgyógyász)
Cím:	Plasminogen activator inhibitor-1 level correlates with lipoprotein subfractions in obese non-diabetic subjects / Sándor Somodi, Ildikó Seres, Hajnalka Lőrincz, Mariann Harangi, Péter Fülöp, György Paragh
Dátum:	2018
Megjegyzések:	Background. The elevated level of plasminogen activator inhibitor-1 (PAI-1) in obese subjects with metabolic syndrome and in patients with type 2 diabetes is well established. Association of plasma PAI-1 and lipid metabolism is still unclear. The aim of the present study was to determine the relationship between plasma PAI-1 levels and the distribution of lipoprotein subfractions in obese and lean non-diabetic individuals. Subjects and Methods. We enrolled fifty non-diabetic obese patients and thirty-two healthy volunteers. Lipoprotein subfractions were detected with Lipoprint System. Plasma PAI-1, tumor necrosis factor-? (TNF-?), interleukin-6 (IL-6) and myeloperoxidase (MPO) concentrations were determined with enzyme-linked immunosorbent assay (ELISA), while serum paraoxonase-1 (PON1) activities were measured by spectrophotometry.Results. The TNF-?, IL-6, oxidized low-density-lipoprotein (oxLDL) and MPO levels were found to be significantly higher, while PON1 paraoxonase and arylesterase activities were non-significantly lower in the obese patients. Strong significant negative correlations were found between plasma PAI-1 concentration and mean LDL-size; as well as between PAI-1 concentrations and the levels of the large and intermediate high-density-lipoprotein (HDL) subfractions. In multiple regression analysis, PAI-1 was predicted by waist circumference and intermediate HDL subfraction. Conclusion. The significant correlations between PAI-1 levels and lipoprotein subfractions indicate the link between PAI-1 and lipid metabolism in obesity.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban PAI-1 obesity HDL subfractions
Megjelenés:	International Journal of Endocrinology. - 2018 (2018), p. 1-9. -
További szerzők:	Seres Ildikó (1954-) (biokémikus) Lőrincz Hajnalka (1986-) (biológus) Harangi Mariann (1974-) (belgyógyász, endokrinológus) Fülöp Péter (1974-) (belgyógyász, endokrinológus, lipidológus) Paragh György (1953-) (belgyógyász)
Pályázati támogatás:	OTKA-115723 OTKA GINOP-2.3.2-15-2016-00005 GINOP
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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