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001-es BibID:	BIBFORM125172
035-os BibID:	(scopus)85207507392 (WOS)001341961400001
Első szerző:	Berta Eszter (belgyógyász)
Cím:	Low Serum Fibroblast Growth Factor 21 Level and Its Altered Regulation by Thyroid Hormones in Patients with Hashimoto's Thyroiditis on Levothyroxine Substitution / Berta Eszter, Halmi Sándor, Molnár István, Hutkai Dávid, Csiha Sára, Bhattoa Harjit Pal, Lőrincz Hajnalka, Somodi Sándor, Katkó Mónika, Harangi Mariann, Paragh György, Nagy Endre V., Bodor Miklós
Dátum:	2024
ISSN:	2218-1989
Megjegyzések:	Background/Objectives: Fibroblast growth factor 21 (FGF21) is a hormonal regulator of lipid and glucose metabolism exerting protection against atherosclerosis by multiple actions on the blood vessels, liver, and adipose tissues. We aimed to investigate serum FGF21 level and its relation to thyroid hormones and metabolic parameters among patients with Hashimoto's thyroiditis (HT). Methods: Eighty patients with HT on levothyroxine treatment and eighty-two age- and BMI-matched adults without thyroid disease serving as controls were enrolled. Serum FGF21 concentrations were determined with an enzyme-linked immunosorbent assay. Results: Median serum FGF21 level was significantly lower in HT patients compared with controls (74.2 (33.4?148.3) pg/mL vs. 131.9 (44.8?236.3) pg/mL; p = 0.03). We found a positive correlation between FGF21 and age, triglyceride, total cholesterol, and low-density lipoprotein cholesterol in both groups, while thyroid stimulating hormone and C-reactive protein showed a positive correlation, and thyroxine had an inverse correlation with FGF21 only in control subjects. According to multiple regression analyses, thyroid status is the main predictor of FGF21 in healthy controls, while it is not a significant predictor of FGF21 among HT patients on levothyroxine supplementation therapy. Conclusions: Our results indicate that the physiological role of thyroid function in the regulation of FGF21 synthesis is impaired in HT patients, which may contribute to the metabolic alterations characteristic of HT patients.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk thyroid fibroblast growth factor 21 FGF21 Hashimoto's thyroiditis levothyroxine hyperlipidemia hypothyroidism
Megjelenés:	Metabolites. - 14 : 10 (2024), p. 1-10. -
További szerzők:	Halmi Sándor (1986-) (belgyógyász) Molnár István Hutkai Dávid (1990-) (belgyógyász, nefrológus) Csiha Sára (1985-) (Biológus) Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Lőrincz Hajnalka (1986-) (biológus) Somodi Sándor (1977-) (belgyógyász) Katkó Mónika (1980-) (biológus) Harangi Mariann (1974-) (belgyógyász, endokrinológus) Paragh György (1953-) (belgyógyász) Nagy Endre V. (1957-) (belgyógyász, endokrinológus) Bodor Miklós (1969-) (belgyógyász, endokrinológus)
Pályázati támogatás:	K142273 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM108726
035-os BibID:	(Scopus)85148902237 (WoS)000940561800001
Első szerző:	Lőrincz Hajnalka (biológus)
Cím:	Crucial Regulatory Role of Organokines in Relation to Metabolic Changes in Non-Diabetic Obesity / Lőrincz Hajnalka, Somodi Sándor, Ratku Balázs, Harangi Mariann, Paragh György
Dátum:	2023
ISSN:	2218-1989
Megjegyzések:	Obesity is characterized by an excessive accumulation of fat leading to a plethora of medical complications, including coronary artery disease, hypertension, type 2 diabetes mellitus or impaired glucose tolerance and dyslipidemia. Formerly, several physiological roles of organokines, including adipokines, hepatokines, myokines and gut hormones have been described in obesity, especially in the regulation of glucose and lipid metabolism, insulin sensitivity, oxidative stress, and low-grade inflammation. The canonical effect of these biologically active peptides and proteins may serve as an intermediate regulatory level that connects the central nervous system and the endocrine, autocrine, and paracrine actions of organs responsible for metabolic and inflammatory processes. Better understanding of the function of this delicately tuned network may provide an explanation for the wide range of obesity phenotypes with remarkable inter-individual differences regarding comorbidities and therapeutic responses. The aim of this review is to demonstrate the role of organokines in the lipid and glucose metabolism focusing on the obese non-diabetic subgroup. We also discuss the latest findings about sarcopenic obesity, which has recently become one of the most relevant metabolic disturbances in the aging population.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk metabolically healthy obesity non-diabetic obesity adipokine hepatokine myokine sarcopenic obesity prediabetes insulin resistance cardiovascular risk
Megjelenés:	Metabolites. - 13 : 2 (2023), p. 1-27. -
További szerzők:	Somodi Sándor (1977-) (belgyógyász) Ratku Balázs (1985-) (mentőtiszt) Harangi Mariann (1974-) (belgyógyász, endokrinológus) Paragh György (1953-) (belgyógyász)
Pályázati támogatás:	OTKA K142273 Egyéb OTKA PD124126 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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