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001-es BibID:BIBFORM030480
Első szerző:Novák János
Cím:Helicobacter pylori-ellenes antitestszint-emelkedés Schönlem-Henoch-puipurában / Novák János, Csiki Zoltán, Sebesi Judit, Takáts Alajos, Demeter Pál, Sipka Sándor
Tárgyszavak:Orvostudományok Klinikai orvostudományok magyar nyelvű folyóiratközlemény hazai lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Orvosi Hetilap. - 144 : 6 (2003), p. 263-267. -
További szerzők:Csiki Zoltán (1962-) (belgyógyász, allergológus, klinikai immunológus, reumatológus) Sebesi Judit Takáts Alajos (1955-) Demeter Pál Sipka Sándor (1945-) (laboratóriumi szakorvos)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat


001-es BibID:BIBFORM030479
Első szerző:Novák János
Cím:Die Schoenlein-Henoch-Purpura bei Erwachsenen (Gastrointestinale Manifestationen und Endoscopie) / J. Novák, J. Marki-Zay, Z. Csiki, J. Sebesi, A. Takáts, S. Sipka
Megjegyzések:During a 15-year-period 62 adult patients were admitted with diagnosis of Schoenlein-Henoch purpura in our hospital. 25 female and 37 male patients ranged from 30-87 years (mean: 59.5 years) presenting with cutaneous, joint, renal and particularly abdominal involvement were investigated retrospectively. During the course of the disease, all patients developed purpuric rash (100 %), 14 (22,5 %) patients had joint symptoms and renal involvement occurred in 12 (19,3 %) patients. In this study, we discuss 15 (24 %) patients with gastrointestinal symptoms appearing in Henoch's purpura. Analysis of the gastrointestinal clinical features revealed: Abdominal pain 13 (86 %), massive colorectal bleeding 3 (20 %), occult blood loss 10 (66 %) vomiting 6 (40 %) and diarrhea in 3 (20 %) patients. Surgical consultation was obtained for 4 of the 15 patients and laparotomy was performed in 2 patients. All the patients underwent lower and upper endoscopic examination, in 3 cases the authors saw purpuric mucosal lesions in duodenum and in 8 patients were also found coin-like elevated lesions, additionally, biopsy from colonic lesions showed leukocytoclastic vasculitis. It is concluded that endoscopy may play a very important role in the diagnosis and treatment of Schoenlein-Henoch purpura.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Zeitschrift für Gastroenterologie. - 39 : 9 (2001), p. 775-782. -
További szerzők:Marki-Zay János Csiki Zoltán (1962-) (belgyógyász, allergológus, klinikai immunológus, reumatológus) Sebesi Judit Takáts Alajos (1955-) Sipka Sándor (1945-) (laboratóriumi szakorvos)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat


001-es BibID:BIBFORM007075
Első szerző:Novák János
Cím:Elevated levels of anti-Helicobacter pylori antibodies in Henoch-Schonlein purpura / Novak, J., Szekanecz, Z., Sebesi, J., Takats, A., Demeter, P., Bene, L., Sipka, S., Csiki, Z.
ISSN:0891-6934 (Print)
Megjegyzések:Henoch-Schonlein purpura (HSP) is a systemic vasculitis characterized by IgA-containing deposits in the skin, joints, gastrointestinal mucosa and glomeruli. HSP is much rarer in adults than in children. Among a number of other pathogenic factors, Helicobacter pylori (Hp) has recently been implicated in the gastrointestinal and extra-gastrointestinal manifestations underlying HSP. We aimed at studying the occurrence of Hp infections in 11 adult HSP patients with appearance in our clinical practice in the last 5 years. METHODS: Eleven adult HSP and 20 healthy adult patients were recruited for this study. Anti-Hp IgG and IgA antibodies were assessed in sera of HSP patients with active (n = 5) and remittent disease (n = 6) and healthy controls (n = 20) in the context of clinical symptoms, endoscopic evaluation, as well as routine and immunolaboratory observations. Concurrent Hp infection was confirmed by urease test and histology. RESULTS: Anti-Hp antibodies were present in 10/11 of HSP patients, and 11/20 of healthy controls. However, only 4/11 HSP patients had concurrent Hp infection as confirmed by urease test and/or histology. In the healthy controls the actual Hp infection was detectable in 9/20 cases. Patients in the acute phase had significantly higher levels of anti-Hp IgG compared to healthy controls (86.0 +/- 32.0 versus 25.5 +/- 28.5 U/ml, p < 0.05). In contrast, anti-Hp IgA/IgG ratios were significantly higher in the remitting phase compared to the control group (3.1 +/- 1.8 versus 0.8 +/- 0.5 ratio, p < 0.05). Among other immunolaboratory markers, serum CRP, circulating IgA and serum tumor necrosis factor-alpha levels were significantly increased in acute patients compared to healthy group results (45.3 +/- 22.7 versus 4.8 +/- 3.5 mg/l, p < 0,05); (58.9 +/- 18.2 versus 25.2 +/- 6.4pg/ml, p < 0,05); (5.5 +/- 1.1 versus 2.4 +/- 1.2 g/l; respectively, p < 0.05). CONCLUSIONS: Hp infection may be associated with the development and progression of HSP. IgG antibodies to Hp may be present mostly in acute HSP, while IgA antibodies may be involved in sustaining gastrointestinal symptoms underlying the chronic phase of the disease.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Acute Disease
Antibodies, Bacterial
C-Reactive Protein
Enzyme-Linked Immunosorbent Assay
Gastric Mucosa
Helicobacter Infections
Helicobacter pylori
Immunoglobulin A
Intestinal Mucosa
Middle Aged
Purpura, Schoenlein-Henoch
Reference Values
Tumor Necrosis Factor-alpha
egyetemen (Magyarországon) készült közlemény
Megjelenés:Autoimmunity. - 36 : 5 (2003), p. 307-311. -
További szerzők:Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Sebesi Judit Takáts Alajos (1955-) Demeter Pál Bene László (Budapest) Sipka Sándor (1945-) (laboratóriumi szakorvos) Csiki Zoltán (1962-) (belgyógyász, allergológus, klinikai immunológus, reumatológus)
Internet cím:elektronikus változat
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