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001-es BibID:	BIBFORM028734
Első szerző:	Szondy Zsuzsanna (molekuláris sejtbiológus, biokémikus)
Cím:	Differential expression of tissue transglutaminase during in vivo apoptosis of thymocytes induced via distinct signalling pathways / Zsuzsa Szondy, Peter Molnar, Zoltán Nemes, Michael Boyiadzis, Noémi Kedei, Réka Tóth, László Fésüs
Dátum:	1997
ISSN:	0014-5793
Megjegyzések:	A significant increase in the expression and activity of tissue transglutaminase (tTG), one of the effector elements of apoptosis, was observed during involution of thymus elicited by treatment with either anti-CD3 antibody or dexamethasone or by irradiation. The blood plasma concentration of epsilon(gamma-glutamyl)lysine isodipeptide, the end-product of the digestion of transglutaminase cross-linked proteins, was also elevated in each of these cases. tTG was localized in cells of the cortical layer of the thymus and immunofluorescence double staining revealed that the enzyme appeared in the apoptotic cells. None of these observations could be made when apoptosis was induced by fas-receptor stimulation. The lack of tTG activity in fas-stimulated cells was accompanied with a less organized apoptotic morphology. Our data suggest that distinct signalling pathways, which induce apoptosis within the same cell type, can differentially regulate the expression of tTG, and this enzyme may be involved in structural stabilization of the apoptotic cells.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Febs Letters. - 404 : 2-3 (1997), p. 307-313. -
További szerzők:	Molnár Péter Pál (1951-) (pathológus) Nemes Zoltán (1969-) (molekuláris biológus, pszichiáter) Boyiadzis, Michael Kedei Noémi Révészné Tóth Réka (1969-) (molekuláris biológus, biokémikus) Fésüs László (1947-) (orvos biokémikus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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