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001-es BibID:	BIBFORM117880
035-os BibID:	(WOS)001116143800001 (Scopus)85181481512
Első szerző:	Panchawagh, Suhrud
Cím:	COVID-19 breakthrough infections in type 1 diabetes mellitus : a cross-sectional study by the COVID-19 Vaccination in Autoimmune Diseases (COVAD) Group / Panchawagh Suhrud, Ravichandran Naveen, Barman Bhupen, Nune Arvind, Javaid Mahnoor, Gracia-Ramos Abraham Edgar, Day Jessica, Joshi Mrudula, Kuwana Masataka, Saha Sreoshy, Pande Arunkumar R., Caballero-Uribe Carlo Vinicio, Velikova Tsvetelina, Parodis Ioannis, Knitza Johannes, Kadam Esha, Tan Ai Lyn, Shinjo Samuel Katsuyuki, Boro Hiya, COVAD Study Group, Aggarwal Rohit, Agarwal Vikas, Chatterjee Tulika, Gupta Latika
Dátum:	2023
ISSN:	0172-8172 1437-160X
Megjegyzések:	To investigate the frequency, profile, and severity of COVID-19 breakthrough infections (BI) in patients with type I diabetes mellitus (T1DM) compared to healthy controls (HC) after vaccination. The second COVID-19 Vaccination in Autoimmune Diseases (COVAD-2) survey is a multinational cross-sectional electronic survey which has collected data on patients suffering from various autoimmune diseases including T1DM. We performed a subgroup analysis on this cohort to investigate COVID-19 BI characteristics in patients with T1DM. Logistic regression with propensity score matching analysis was performed. A total of 9595 individuals were included in the analysis, with 100 patients having T1DM. Among the fully vaccinated cohort, 16 (16%) T1DM patients had one BI and 2 (2%) had two BIs. No morbidities or deaths were reported, except for one patient who required hospitalization with oxygen without admission to intensive care. The frequency, clinical features, and severity of BIs were not significantly different between T1DM patients and HCs after adjustment for confounding factors. Our study did not show any statistically significant differences in the frequency, symptoms, duration, or critical care requirements between T1DM and HCs after COVID-19 vaccination. Further research is needed to identify factors associated with inadequate vaccine response in patients with BIs, especially in patients with autoimmune diseases.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Breakthrough infections COVID-19 Survey Type 1 diabetes mellitus Vaccine
Megjelenés:	Rheumatology International. - 44 : 1 (2023), p. 73-80. -
További szerzők:	Ravichandran, Naveen Barman, Bhupen Nune, Arvind Javaid, Mahnoor Gracia-Ramos, Abraham Edgar Day, Jessica Joshi, Mrudula Kuwana, Masataka Saha, Sreoshy Pande, Arunkumar R. Caballero-Uribe, Carlo Vinicio Velikova, Tsvetelina Parodis, Ioannis Knitza, Johannes Kadam, Esha Tan, Ai Lyn Shinjo, Samuel Katsuyuki Boro, Hiya Aggarwal, Rohit Agarwal, Vikas Chatterjee, Tulika Gupta, Latika Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Nagy-Vincze Melinda (1985-) (orvos) COVAD Study Group
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001-es BibID:	BIBFORM129436
035-os BibID:	(Scopus)85214870744 (WoS)001394766200001
Első szerző:	Shaharir, Syahrul Sazliyana
Cím:	Self-Reported Delayed Adverse Events and Flare Following COVID-19 Vaccination Among Patients With Autoimmune Rheumatic Disease (AIRD) in Malaysia : results From the COVAD-2 Study / Syahrul Sazliyana Shaharir, Azmawati Mohammed Nawi, Theepa Nesam Mariamutu, Lydia Kamaruzaman, Mohd Shahrir Mohamed Said, Sakthiswary Rajalingham, Ioannis Parodis, Manali Sarkar, Samuel Katsuyuki Shinjo, Esha Kadam, Nelly Ziade, Chou Luan Tan, Francis Gullemin, Carlo Vincio Caballero-Uribe, Ai Lyn Tan, Laura Andreoli, Jasmine Parihar, Praggya Yaadav, Sreoshy Saha, Latika Gupta, Vikas Agarwal, COVAD Study Group
Dátum:	2025
ISSN:	1756-1841
Megjegyzések:	Objectives To determine the prevalence of self-reported delayed adverse events (DAEs), major AEs, and flares following COVID-19 vaccinations among patients with autoimmune rheumatic diseases (AIRDs) in Malaysia. Methodology An electronically validated survey from the COVID-19 vaccination in autoimmune diseases (COVAD) study group was distributed in July 2021 to patients with autoimmune diseases and healthy controls (HCs). The survey collected data on DAEs (any AE that persisted or occurred after 7?days of vaccination), any early or delayed major adverse events (MAEs), and flares following COVID-19 vaccination. Generalized estimating equation (GEE) models were performed to determine the factors associated with repeated events of DAEs, MAEs, and flares. Results A total of 556 vaccines were administered to 204 subjects (150 AIRDs and 54 HCs), with 72.1% completing 3 doses. In multivariate GEE analysis, there was a greater frequency of minor DAEs among AIRDs versus HCs (OR 5.65, p?=?0.052). The occurrence of MAEs was higher in AIRDs versus HCs (4.9% vs. 1.3%, p?=?0.052), but it was no longer significant in the GEE model. In the AIRDs group, the BNT162b2 vaccine increased the risk for minor DAEs (OR4.68, p?=?0.02) while patients with autoimmune multimorbidity showed a greater risk for MAEs (OR 8.25, p?=?0.007). The rate of flare was 10.6% and multivariate GEE analysis revealed that The rate of flare was 10.6% and multivariate GEE analysis revealed that systemic lupus erythematosus (SLE) (OR0.31, p?=?0.03) and hydroxychloroquine (HCQ) (OR 0.16, p?<?0.001) were protective against flare. Conclusion The rates of minor DAEs, major AEs, and flares were comparable with other reported studies. Different types of vaccines, underlying AIRDs, and treatments may influence the symptoms of AEs and flares postvaccination against COVID-19.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk COVID-19 vaccine autoimmunity flares quality of life
Megjelenés:	International Journal of Rheumatic Diseases. - 28 : 1 (2025), p. 1-14. -
További szerzők:	Nawi, Azmawati Mohammed Mariamutu, Theepa Nesam Kamaruzaman, Lydia Said, Mohd Shahrir Mohamed Rajalingham, Sakthiswary Parodis, Ioannis Sarkar, Manali Shinjo, Samuel Katsuyuki Kadam, Esha Ziade, Nelly Tan, Chou Luan Gullemin, Francis Caballero-Uribe, Carlo Vinicio Tan, Ai Lyn Andreoli, Laura Parihar, Jasmine Yaadav, Praggya Saha, Sreoshy Gupta, Latika Agarwal, Vikas Nagy-Vincze Melinda (1985-) (orvos) Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) COVAD Study Group
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001-es BibID:	BIBFORM129446
035-os BibID:	(Scopus)85188738177 (WoS)001189792100001
Első szerző:	Yoshida, Akira
Cím:	Impaired health-related quality of life in idiopathic inflammatory myopathies : a cross-sectional analysis from the COVAD-2 e-survey / Akira Yoshida, Yuan Li, Vahed Maroufy, Masataka Kuwana, Syahrul Sazliyana Shaharir, Ashima Makol, Parikshit Sen, James B. Lilleker, Vishwesh Agarwal, Esha Kadam, Phonpen Akawatcharangura Goo, Jessica Day, Marcin Milchert, Yi-Ming Chen, Dzifa Dey, Tsvetelina Velikova, Sreoshy Saha, Abraham Edgar Gracia-Ramos, Ioannis Parodis, Elena Nikiphorou, Ai Lyn Tan, Arvind Nune, Lorenzo Cavagna, Carlos Enrique Toro Gutierrez, Carlo Vinicio Caballero-Uribe, Miguel A. Saavedra, Samuel Katsuyuki Shinjo, Nelly Ziade, Lina El Kibbi, Johannes Knitza, Oliver Distler, Hector Chinoy, Vikas Agarwal, Rohit Aggarwal, Latika Gupta, COVAD Study Group
Dátum:	2024
ISSN:	2514-1775
Megjegyzések:	Objectives: To investigate health-related quality of life in patients with idiopathic inflammatory myopathies (IIMs) compared with those with non-IIM autoimmune rheumatic diseases (AIRDs), non-rheumatic autoimmune diseases (nrAIDs) and without autoimmune diseases (controls) using Patient-Reported Outcome Measurement Information System (PROMIS) instrument data obtained from the second COVID-19 vaccination in autoimmune disease (COVAD-2) e-survey database. Methods: Demographics, diagnosis, comorbidities, disease activity, treatments and PROMIS instrument data were analysed. Primary outcomes were PROMIS Global Physical Health (GPH) and Global Mental Health (GMH) scores. Factors affecting GPH and GMH scores in IIMs were identified using multivariable regression analysis. Results: We analysed responses from 1582 IIM, 4700 non-IIM AIRD and 545 nrAID patients and 3675 controls gathered through 23 May 2022. The median GPH scores were the lowest in IIM and non-IIM AIRD patients {13 [interquartile range (IQR) 10-15] IIMs vs 13 [11-15] non-IIM AIRDs vs 15 [13-17] nrAIDs vs 17 [15-18] controls, P < 0.001}. The median GMH scores in IIM patients were also significantly lower compared with those without autoimmune diseases [13 (IQR 10-15) IIMs vs 15 (13-17) controls, P < 0.001]. Inclusion body myositis, comorbidities, active disease and glucocorticoid use were the determinants of lower GPH scores, whereas overlap myositis, interstitial lung disease, depression, active disease, lower PROMIS Physical Function 10a and higher PROMIS Fatigue 4a scores were associated with lower GMH scores in IIM patients. Conclusion: Both physical and mental health are significantly impaired in IIM patients, particularly in those with comorbidities and increased fatigue, emphasizing the importance of patient-reported experiences and optimized multidisciplinary care to enhance well-being in people with IIMs.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk e-survey myositis patient-reported outcome measures quality of life
Megjelenés:	Rheumatology Advances in Practice. - 8 : 2 (2024), p. 1-14. -
További szerzők:	Li, Yuan Maroufy, Vahed Kuwana, Masataka Sazliyana Shaharir, Syahrul Makol, Ashima Sen, Parikshit Lilleker, James B. Agarwal, Vishwesh Kadam, Esha Akawatcharangura Goo, Phonpen Day, Jessica Milchert, Marcin Chen, Yi-Ming Dey, Dzifa Velikova, Tsvetelina Saha, Sreoshy Edgar Gracia-Ramos, Abraham Parodis, Ioannis Nikiphorou, Elena (reumatológus) Tan, Ai Lyn Nune, Arvind Cavagna, Lorenzo Toro Gutiérrez, Carlos Enrique Caballero-Uribe, Carlo Vinicio Saavedra, Miguel A. Shinjo, Samuel Katsuyuki Ziade, Nelly El Kibbi, Lina Knitza, Johannes Distler, Oliver Chinoy, Hector Agarwal, Vikas Aggarwal, Rohit Gupta, Latika Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Nagy-Vincze Melinda (1985-) (orvos) COVAD Study Group
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