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001-es BibID:BIBFORM068569
Első szerző:Addya, Sankar
Cím:Ischemic preconditioning-mediated cardioprotection is disrupted in heterozygous Flt-1 (VEGFR-1) knockout mice / Sankar Addya, Keisuke Shiroto, Tibor Turoczi, Lijun Zhan, Shigeaki Kaga, Shoji Fukuda, Saul Surrey, Li-Juan Duan, Guo-Hua Fong, Fumio Yamamoto, Nilanjana Maulik
Megjegyzések:AbstractThis study attempts to address an important clinical issue by identifying potential candidates of VEGF signaling through Flt-1 receptor that trigger angiogenic signal under ischemic stress. To determine the significance of VEGF-Flt-1 (VEGFR1) signaling in ischemic preconditioned (PC) myocardium, we used heterozygous Flt-1 knockout (KO) mice to dissect the pathway and identify candidate genes involved in VEGF signaling. DNA microarrays were employed to detect, characterize and distinguish altered myocardial gene expression by comparing between wild type (WT) CD-1 and heterozygous Flt-1 KO mice when exposed to ischemia (30 min) and reperfusion (2 h). Moreover, KO mice demonstrated reduced beneficial effects of PC when compared to the WT with PC. In the KO and WT mice, the % recovery of the left ventricular developed pressure and the maximum first derivative of the developed pressure after ischemia/reperfusion without PC were similar. However, when animals were subjected to PC, the left ventricular functional recovery throughout the reperfusion period was significantly lower in KO mice than in WT mice. These results indicate for the first time that in the heterozygous Flt-1 KO mice, PC is not as effective as that found in WT. This observation may be due to downregulation of several important genes such as growth-regulated oncogene 1 (Gro1), heat shock proteins (HSP), I kappa B kinase ? (IKK?), colony-stimulating factor-1 (CSF-1) and annexin A7, suggesting the importance of VEGF-Flt-1 receptor signaling during PC. ? 2005 Published by Elsevier Ltd.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Molecular And Cellular Cardiology 38 : 2 (2005), p. 345-351. -
További szerzők:Shiroto, Keisuke Turóczi Tibor (1976-) (molekuláris biológus) Zhan, Lijun Kaga, Shigeaki Fukuda, Shoji Surrey, Saul Duan, Li-Juan Fong, Guo-Hua Yamamoto, Fumio Maulik, Nilanjana
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