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001-es BibID:BIBFORM070761
Első szerző:Csoma Eszter (molekuláris biológus, mikrobiológus)
Cím:Survey of KI, WU, MW and STL polyomavirus in cancerous and non-cancerous lung tissues / Eszter Csoma, László Bidiga, Gábor Méhes, Melinda Katona, Lajos Gergely
Dátum:2018
ISSN:1015-2008
Megjegyzések:BACKGROUND/AIMS: The pathogenesis of the human polyomavirus (PyV) KI, WU, MW, and STL has not been elucidated yet. Respiratory transmission is suggested, but the site of the replication, tissue, and cell tropism is not clarified. KIPyV and WUPyV DNA and/or antigen were detected in normal lung tissues previously by others. In fact, a KIPyV DNA sequence was found in lung cancer samples. Up to date, there is no publication about the DNA prevalence of MWPyV and STLPyV neither in normal nor in cancerous lung tissues. The aim of the present study was to examine the DNA prevalence of these polyomaviruses in cancerous and non-cancerous lung tissue samples, in order to study the possible site for viral replication and/or persistence, and the potential association of these viruses with lung carcinogenesis as well. METHODS: 100 cancerous and 47 non-cancerous, formalin-fixed paraffin-embedded lung tissue samples were studied for KIPyV, WUPyV, MWPyV, and STLPyV by real-time PCR. RESULTS AND CONCLUSION: Neither of the viruses was found in samples from small-cell, non-small-cell (adenocarcinoma, squamous-cell carcinoma and large-cell neuroendocrine lung cancer), mixed-type and non-differentiated lung carcinoma, and non-cancerous lung tissues (from patients with pneumonia, emphysema and fibrosis).
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
polyomavirus
lung
cancer
Megjelenés:Pathobiology 85 : 3 (2018), p. 179-185. -
További szerzők:Bidiga László (1977-) (patológus) Méhes Gábor (1966-) (patológus) Katona Melinda (1992-) (molekuláris biológus) Gergely Lajos (1940-) (szakorvos, klinikai mikrobiológus)
Pályázati támogatás:109108
OTKA
TÁMOP-4.2.4.A/ 2-11/1-2012-0001
TÁMOP
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